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Studies on the function of the fungal effector NIS1 for suppression of plant immunity

Research Project

Project/Area Number 15H04457
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Plant protection science
Research InstitutionKyoto University

Principal Investigator

Takano Yoshitaka  京都大学, 農学研究科, 教授 (80293918)

Co-Investigator(Renkei-kenkyūsha) NISHIUCHI TAKUMI  金沢大学, 学際科学実験センター, 准教授 (20334790)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Keywords植物病原糸状菌 / エフェクター / 抵抗性 / PAMPs / タンパク質リン酸化酵素 / PAMP / パターン認識受容体 / 炭疽病菌 / 活性酸素 / イネいもち病菌 / 植物病理学 / 植物免疫 / BAK1 / BIK1 / 糸状菌
Outline of Final Research Achievements

Plant pathogenic fungi establish the infection of their host plants by using a set of secreted proteins called effectors. This study focused on the effector NIS1 identified in a cucumber anthracnose fungus Colletotrichum orbiculare. Plants activate defense responses via the recognition of Pathogen-Associated Molecular Patterns (PAMPs). The study revealed that NIS1, widely conserved in plant pathogenic fungi, targets protein kinases critical for the PAMP-triggered immunity and plays important roles for infection strategies of plant pathogenic fungi including Colletotrichum species.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (29 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 7 results) Presentation (19 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Glutathione transferase U13 functions in pathogen-triggered glucosinolate metabolism2018

    • Author(s)
      Pislewska-Bednarek M, Nakano RT, Hiruma K, Pastorczyk M, Sanchez-Vallet A, Singkaravanit-Ogawa S, Ciesiolka D, Takano Y, Molina A, Schulze-Lefert P, and Bednarek P.
    • Journal Title

      Plant Physiology

      Volume: 176 Issue: 1 Pages: 538-551

    • DOI

      10.1104/pp.17.01455

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inappropriate expression of an NLP effector in Colletotrichum orbiculare impairs infection on Cucurbitaceae cultivars via plant recognition of the C-terminal region.2018

    • Author(s)
      Nur Sabrina Ahmad Azmi, Suthitar Singkaravanit-Ogawa S, Kyoko Ikeda, Saeko Kitakura, Yoshihiro Inoue, Yoshihiro Narusaka, Ken Shirasu, Masanori Kaido, Kazuyuki Mise, and Yoshitaka Takano
    • Journal Title

      Mol. Plant-Microbe Interact.

      Volume: 31 Issue: 1 Pages: 101-111

    • DOI

      10.1094/mpmi-04-17-0085-fi

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Draft genome assembly of Colletotrichum chlorophyti, a pathogen of herbaceous plants2017

    • Author(s)
      Gan, P., Narusaka, M., Tsushima, A., Narusaka, Y., Takano, Y. and Shirasu, K.
    • Journal Title

      Genome Announcement

      Volume: 5 Issue: 10

    • DOI

      10.1128/genomea.01733-16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dysfunction of Arabidopsis MACPF domain protein activates programmed cell death via tryptophan metabolism in MAMP-triggered immunity2017

    • Author(s)
      Fukunaga S, Sogame M, Hata M, Singkaravanit-Ogawa S, Pislewska-Bednarek M, Onozawa-Komori M, Nishiuchi T, Hiruma K, Saitoh H, Terauchi R, Kitakura S, Inoue Y, Bednarek P, Schulze-Lefert P, and Takano Y.
    • Journal Title

      Plant Journal

      Volume: 89 Issue: 2 Pages: 381-393

    • DOI

      10.1111/tpj.13391

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulation of sugar transporter activity for antibacterial defense in Arabidopsis2016

    • Author(s)
      Yamada K, Saijo Y, Nakagami H, Takano Y
    • Journal Title

      Science

      Volume: 354(6318) Issue: 6318 Pages: 1427-1430

    • DOI

      10.1126/science.aah5692

    • NAID

      120005895801

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genus-wide comparative genome analyses of Colletotrichum species reveal specific gene family losses and gains during adaptation to specific infection lifestyles.2016

    • Author(s)
      Gan, P., Narusaka, M., Kumakura, N., Tsushima, A., Takano, Y., Narusaka, Y., Shirasu, K.
    • Journal Title

      Genome Biology and Evolution.

      Volume: 8 Issue: 5 Pages: 1467-1481

    • DOI

      10.1093/gbe/evw089

    • NAID

      120006822486

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Focal effector accumulation in a biotrophic interface at the primary invasion sites of Colletotrichum orbiculare in multiple susceptible plants.2016

    • Author(s)
      Hiroki Irieda, Suthitar Ogawa and Yoshitaka Takano.
    • Journal Title

      Plant Signaling & Behavior

      Volume: 11 Issue: 2 Pages: e1137407-e1137407

    • DOI

      10.1080/15592324.2015.1137407

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification and characterization of virulence- related effectors in the cucumber anthracnose fungus Colletotrichum orbiculare2016

    • Author(s)
      Hiroki Irieda and Yoshitaka Takano.
    • Journal Title

      Physiological and Molecular Plant Pathology

      Volume: 94 Pages: 87-92

    • DOI

      10.1016/j.pmpp.2016.01.006

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Leucine zipper motif in RRS1 is crucial for the regulation of Arabidopsis dual resistance protein complex RPS4/RRS12016

    • Author(s)
      Narusaka M, Toyoda K, Shiraishi T, Iuchi S, Takano Y, Shirasu K, Narusaka Y.
    • Journal Title

      Scientifc Reports

      Volume: 6 Issue: 1 Pages: 18702-18702

    • DOI

      10.1038/srep18702

    • NAID

      120005819504

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Oil body-mediated defense against fungi : From tissues to ecology2015

    • Author(s)
      Shimada TL, Takano Y, Hara-Nishimura I.
    • Journal Title

      Plant Signal Behav

      Volume: 10 Issue: 2 Pages: 1559-1559

    • DOI

      10.4161/15592324.2014.989036

    • NAID

      120005646470

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 比較ゲノム・トランスクリプトーム解析によるウリ類炭疽病菌の強病原性関連因子の探索2018

    • Author(s)
      井上 喜博・Pamela Gan・鳴坂 義弘・白須 賢・高野 義孝
    • Organizer
      平成30年度日本植物病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウリ類炭疽病菌の宿主特異性に関する研究:アルファルファ炭疽病菌との比較解析2018

    • Author(s)
      小川泰生・井上喜博・Pamela Gan・海道真典・三瀬和之・鳴坂 義弘・白須 賢・高野義孝
    • Organizer
      平成30年度日本植物病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウリ類炭疽病菌は転写制御因子SGE1依存的にメロン根部へ感染し植物体の萎凋症状を引き起こす2018

    • Author(s)
      田中冬樹・Suthitar Singkaravanit-Ogawa・海道真典・三瀬和之・高野義孝
    • Organizer
      平成30年度日本植物病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 植物と炭疽病菌の攻防戦2018

    • Author(s)
      高野義孝
    • Organizer
      第10回植物ストレス科学研究シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ホスファチジルイノシトールリン酸を介した炭疽病菌感染機構の解明2017

    • Author(s)
      島田 貴士、高野 義孝、別役 重之、中野 明彦、上田 貴志
    • Organizer
      第58回日本植物生理学会年会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 炭疽病菌と植物の相互作用:エフェクター研究を中心に2017

    • Author(s)
      高野義孝
    • Organizer
      第17回糸状菌分子生物学コンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Involvement of tryptophan-derived secondary metabolism in post-invasive resistance of Arabidopsis thaliana against fungal pathogens2017

    • Author(s)
      Kosaka A, Bednarek P, Ishikawa A, Kaido M, Mise K, and Takano Y.
    • Organizer
      平成29年度日本植物病理学会関西部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ウリ類炭疽病菌RSCO-09-1-2株の強病原性に関する分子機構研究2017

    • Author(s)
      井上 喜博・Pamela Gan・鳴坂 義弘・白須 賢・高野 義孝
    • Organizer
      平成29年度日本植物病理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inappropriate expression of NLP effector impairs Colletotrichum infection on cucurbits via recognition of its C-terminal region2017

    • Author(s)
      Singkaravanit-Ogawa S, Nur Sabrina AA, Ikeda K, Tanaka S, Inoue Y, Kaido M, Mise K, Narusaka Y, Shirasu K, and Takano Y.
    • Organizer
      平成29年度日本植物病理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inappropriate expression of the NLP effector impairs the infection of Colletotrichum orbiculare on cucumber2016

    • Author(s)
      Nur Sabrina Ahmad Azmi, Suthitar Singkaravanit-Ogawa, Kyoko Ikeda, Masanori Kaido, Kazuyuki Mise, and Yoshitaka Takano
    • Organizer
      平成28年度日本植物病理学会関西部会
    • Place of Presentation
      静岡県コンベンションセンター
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウリ類炭疽病菌の強病原性株RSCO-09-1-2の強病原性化因子の探索2016

    • Author(s)
      井上喜博、Pamela Gan、鳴坂義弘、白須 賢、高野義孝
    • Organizer
      平成28年度日本植物病理学会関西部会
    • Place of Presentation
      静岡県コンベンションセンター
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Comparative genomics of Colletotrichum fungi reveals lifestyle-adapted fungal gene gain/loss andn potential virulence-associated genes2016

    • Author(s)
      Pamela Gan, Mari Narusaka, Naoyoshi Kumakura, Ayako Tsushima, Ryoko Hiroyama, Yoshitaka Takano, Yoshihiro Narusaka, Ken Shirasu
    • Organizer
      European Fungal Genomics Conference 13
    • Place of Presentation
      PARIS-LA VILLETTE
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 糸状菌エフェクターNIS1は高等植物のPRR複合体における複数の因子を攻撃する2016

    • Author(s)
      入枝泰樹、森正之、山田晃嗣、押川友、大木進野、齋藤宏昌、寺内良平、高野義孝
    • Organizer
      平成28年度日本植物病理学会大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] ウリ類炭疽病菌の強病原性株RSCO-09-1-2に関する研究2016

    • Author(s)
      井上喜博、Pamela Gan、鳴坂義弘、白須 賢、高野義孝
    • Organizer
      平成28年度日本植物病理学会大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] ウリ類炭疽病菌の付着器において発現するエフェクター候補群ECAPの機能解析2016

    • Author(s)
      奥田竜太、石塚隼也、Suthitar Singkaravanit-Ogawa、Pamela Gan、山田晃嗣、鳴坂義弘、白須 賢、高野義孝
    • Organizer
      平成28年度日本植物病理学会大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 比較ゲノム解析を用いたColletotrichum属菌における病原性エフェクターの探索2016

    • Author(s)
      熊倉直祐、Pamela Gan、津島綾子、浅井秀太、門田康弘、鳴坂真理、鳴坂義弘、高野義孝、白須賢
    • Organizer
      平成28年度日本植物病理学会大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] コアエフェクター候補遺伝子CCE1はColletotrichum属菌に保存され、細胞死を誘導する2016

    • Author(s)
      津島 綾子、鳴坂 真理、Pamela Gan、熊倉 直祐、浅井 秀太、門田 康弘、高野 義孝、鳴坂 義弘、白須 賢
    • Organizer
      平成28年度日本植物病理学会大会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effectors in Colletotrichum orbiculare2015

    • Author(s)
      Yoshitaka Takano
    • Organizer
      11th US-Japan Scientific Seminar
    • Place of Presentation
      Kagawa international conference hall
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炭疽病菌の基本的親和性とエフェクター2015

    • Author(s)
      高野義孝
    • Organizer
      平成27年度日本植物病理学会関西部会若手の会
    • Place of Presentation
      徳島県あわぎんホール
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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