| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
In this study, we have conducted a comprehensive analysis of the SUF machinery to gain insights into molecular mechanisms of the iron-sufur (Fe-S) cluster biosynthesis. (1) We have determined crystal structure of the SufBCD complex, and also clarified the mechanism of this complex by mutational and biochemical analyses. (2) We found that SufU and IscU are homologous proteins with different functions, and that SufU serves as a zinc-dependent sulfur carrier protein. These findings provide an essential understanding of the Fe-S cluster biosynthesis by the SUF machinery.
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