| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We synthesized an ω-ethynyl analog of eicosapentaenoic acid (EPA) as a tool for analyzing the in vivo behavior and function of EPA. The analog, named eEPA, has an ω-ethynyl group tag in place of the ω-methyl group of EPA. By using eEPA, we obtained results suggesting that the subcellular distribution of EPA in an EPA-producing bacterium is different from that of palmitoleic acid and that EPA is required for normal assembly of a cell division-related protein, FtsZ. We also found the occurrence of EPA-modified proteins.
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