| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
Combining chemical genomics profiling based on genetic interactions and morphological profiling using a sophisticated image-processing program, CalMorph, we developed a multi-dimensional strategy for linking novel bioactive compounds to their targets and pathways. We established a high-throughput chemical-genetic screening platform to functionally annotate large compound collections in a rapid and systematic manner using next generation sequencing. Furthermore, we assembled a computational platform for functionally annotating compounds to specific biological processes and pathways. Finally, we applied our chemical-genomic/morphological profiling pipeline to annotate 13,524 compounds in total by screening seven diverse compound collections including the RIKEN NPDepo library.
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