| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Outline of Final Research Achievements |
Carbohydrate includes a wide variety of molecules because of the diversity of constituent monosaccharides, linkages, and degrees of polymerization. They are highly expected to contain functional compounds useful for human life. Therefore, various synthetic methods are required for synthesis of various saccharides. In this study, enzymatic conversion from highly abundant carbohydrates in nature was established with two types of enzymes: glycoside synthase and glycosyl transferase. In the method with synthase, sugar nucleotides, substrates for glycoside synthases, were provided from sucrose, and disaccharides were efficiently produced through the one-pot reactions. A new group of glycosyl transferases were found. The enzymes in it acted on maltooligosaccharides and catalyzed glucosyl transfer reactions.
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