| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
This study uncovered the molecular basis of D-mannose (Man) recognition of Pradimicin A (PRM-A) by a combination of X-ray crystallography and solid-state NMR spectroscopy. It is also suggested by binding studies using synthetic oligomannoses that PRM-A could recognize regions in fungal mannans where Man residues at the non-reducing ends are densely located. Based on these findings, we developed two derivatives of PRM-A, PRM-Amide with a less aggregative property and PRM-Azide capable of fluorescently staining fungal mannans.
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