Development of drug leads targeting fungal glycans
| Project/Area Number |
15H04496
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
Nakagawa Yu 名古屋大学, 生命農学研究科, 准教授 (90452284)
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| Co-Investigator(Kenkyū-buntansha) |
竹腰 清乃理 京都大学, 理学研究科, 教授 (10206964)
相田 美砂子 広島大学, 理学研究科, 教授 (90175159)
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| Co-Investigator(Renkei-kenkyūsha) |
OJIKA Makoto 名古屋大学, 大学院生命農学研究科, 教授 (50152492)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 抗生物質 / 糖鎖 / pradimicin / 分子認識 / 有機化学 / 生理活性 |
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| Outline of Final Research Achievements |
This study uncovered the molecular basis of D-mannose (Man) recognition of Pradimicin A (PRM-A) by a combination of X-ray crystallography and solid-state NMR spectroscopy. It is also suggested by binding studies using synthetic oligomannoses that PRM-A could recognize regions in fungal mannans where Man residues at the non-reducing ends are densely located. Based on these findings, we developed two derivatives of PRM-A, PRM-Amide with a less aggregative property and PRM-Azide capable of fluorescently staining fungal mannans.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Pradimicin A, a D-mannose-binding antibiotic, binds pyranosides of L-fucose and L-galactose in a calcium-sensitive manner2015
Author(s)
Nakagawa, Y., Watanabe, Y., Igarashi, Y., Ito, Y. and Ojika, M.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 25
Issue: 15
Pages: 2963-2966
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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