| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Focusing on the immune-modulating functions of food factors, we searched for those inducing or activating regulatory T cells (Tregs) or regulatory B cells (Bregs), which have immune-suppressive functions. The mechanisms of action of the food factors and anti-inflammatory activity in vivo were investigated. We found several flavonoids having such an immune-modulating functions, and observed the suppressive effects of these factors on an animal model of inflammatory bowel diseases. Food factors with immune-suppressive functions are expected to prevent or ameliorate allergies and also lifestyle diseases developing on the basis of chronic inflammation.
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