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Discovery of novel sulfated bioregulatory molecules acting on neural tissue receptors

Research Project

Project/Area Number 15H04502
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionUniversity of Miyazaki

Principal Investigator

SAKAKIBARA YOICHI  宮崎大学, 農学部, 教授 (90295197)

Co-Investigator(Kenkyū-buntansha) 水光 正仁  宮崎大学, 理事・副学長 (00128357)
榊原 啓之  宮崎大学, 農学部, 教授 (20403701)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords硫酸転移酵素 / 硫酸化 / レセプター / 生体制御分子 / sulfation / sulfotransferase / sulfated / GPCR / 生体制御分子硫酸体 / 神経
Outline of Final Research Achievements

In this study, we focused on the functional control of bioregulatory molecules by sulfation as a metabolic mechanism. First, enzymatic preparation method of sulfated bioregulatory molecules were developed. Furthermore, we conducted research aimed at developing analysis technology for cell surface receptor-mediated signal transduction and elucidating its physiological function in cultured cells. Specifically, using E. coli that expressing human cytosolic sulfotransferase, we have established a biotechnology method to prepare a sulfated metabolite of a bioregulatory molecules such as food components. The obtained sulfated metabolite confirmed the chemical structure by NMR. Furthermore, a luciferase assay to evaluate GPR30 receptor-mediated activity was established, and the sulfated metabolites were evaluated for functional analysis.

Academic Significance and Societal Importance of the Research Achievements

現在、市場に流通する医薬品のほとんどがGタンパク質共役受容体を介して作用すると言われ、生体制御分子(ホルモン、食品機能性成分、医薬品など)の多くが受容体を標的として作用する。さらに、これら生体制御分子の多くは、肝臓等で代謝され、その代謝産物が神経細胞などで受容体に作用し機能していることが想定される。本研究は、硫酸化を受けた代謝物が受容体を介して細胞に作用することを確認した。このことは、硫酸化された代謝物は不活性な状態として排泄されているという定説を覆す知見となる。さらに、硫酸化代謝物に新規機能性を開発することで医薬品等の候補分子としての優位性を示すことが可能となる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (57 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (27 results) (of which Int'l Joint Research: 26 results,  Peer Reviewed: 27 results,  Open Access: 20 results,  Acknowledgement Compliant: 1 results) Presentation (26 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] トレド大学(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] トレド大学(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] トレド大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Effects of human sulfotransferase 2A1 genetic polymorphisms 3 on the sulfation of Tibolone.2018

    • Author(s)
      Miller, E., Zalzala, M.H., Abunnaja, M.S, Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      European Journal of Drug Metabolism and Pharmacokinetics

      Volume: - Issue: 4 Pages: 415-421

    • DOI

      10.1007/s13318-017-0458-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sulfation of catecholamines and serotonin by SULT1A3 allozymes.2018

    • Author(s)
      Bairam, A.F., Rasool, M.I., Alherz, F.A., Abunnaja, M.S., El Daibani, A.A., Gohal, S.A., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Biochamical Pharmacology

      Volume: 151 Pages: 104-113

    • DOI

      10.1016/j.bcp.2018.03.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radical scavenging effects of 1-naphthol, 2-naphthol, and their sulfate-conjugates2018

    • Author(s)
      Sugahara S, Fukuhara K, Tokunaga Y, Tsutsumi S, Ueda Y, Ono M, Kurogi K, Sakakibara Y, Suiko M, Liu M-C, Yasuda S.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 43 Issue: 3 Pages: 213-221

    • DOI

      10.2131/jts.43.213

    • NAID

      130006507410

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A12018

    • Author(s)
      Abunnaja, M.S., Alherz, F.A., El, Daibani, A.A., Bairam, A.F., Rasool, M.I., Gohal, S.A., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Biochemistry and Cell Biology

      Volume: 96 Issue: 5 Pages: 655-662

    • DOI

      10.1139/bcb-2017-0341

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7alfa-hydroxyl sulfation of bile acids2018

    • Author(s)
      Shimohira, T., Kurogi, K., Liu, M.-C., Suiko, M., Sakakibara, Y.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 8 Pages: 1359-136

    • DOI

      10.1080/09168451.2018.1464897

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On the role of genetic polymorphisms in the cholesterol by human cytosolic sulphotransferase SULT2B1b2018

    • Author(s)
      Alherz, F.A., Daibani, A.A., Bairam, A.F., Abunnaja, M.S., El, Rasool, M.I., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Journal of Biochemistry

      Volume: 164 Issue: 3 Pages: 215-221

    • DOI

      10.1093/jb/mvy042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase2018

    • Author(s)
      Kurogi, K., Yoshihama, M., Williams, F.E., Kenmochi, N., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: 185 Pages: 110-117

    • DOI

      10.1016/j.jsbmb.2018.08.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of the zebrafish glutathione S-transferase Pi-1.2017

    • Author(s)
      Abunnaja, M. S., Kurogi, K., Mohammed, Y. I., Sakakibara, Y., Suiko, M., Hassoun, E., Liu, M.-C.
    • Journal Title

      Journal of Biochemical and Molecular Toxicology

      Volume: 31 Issue: 10

    • DOI

      10.1002/jbt.21948

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of the responsible human cytosolic sulfotransferases.2017

    • Author(s)
      Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Federation of European Biochemical Societies Letters

      Volume: 591 Issue: 16 Pages: 2417-2425

    • DOI

      10.1002/1873-3468.12767

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Δ4-3-Ketosteroids as a new class of substrates for the cytosolic sulfotransferases.2017

    • Author(s)
      Hashiguchi, T., Kurogi, K., Shimohira, T., Teramoto, T., Liu, M.-C., Suiko, M., Sakakibara, Y.10.1016/j.bbagen.2017.08.005.
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1861 Issue: 11 Pages: 2883-2890

    • DOI

      10.1016/j.bbagen.2017.08.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and characterization of 5alpha-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the Zebrafish (Danio rerio).2017

    • Author(s)
      Kurogi, K., Yoshihama, M., Horton, A., Schiefer, I.T., Krasowski, M.D., Hagey, L.R., Williams, F.E., Sakakibara, Y., Kenmochi, N., Suiko, M., Liu, M.-C.
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: 174 Pages: 120-127

    • DOI

      10.1016/j.jsbmb.2017.08.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotaransferase-1.2017

    • Author(s)
      Tanaka, S., Nishiyori, T., Kojo, H., Otsubo, R., Tsuruta, M., Kurogi, K., Liu, M.-C., Suiko, M., Sakakibara, Y., Kakuta, Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8776-8776

    • DOI

      10.1038/s41598-017-07141-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human cytosolic sulphotransferase SULT1C3: genomic analysis and functional characterization of splice variant SULT1C3 and SULT1C3d.2017

    • Author(s)
      Kurogi, K., Shimohira, T., Kouriki-Nagatomo, H., Zhang, G., Miller, E.R., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Journal of Biochemistry

      Volume: 162 Issue: 6 Pages: 403-414

    • DOI

      10.1093/jb/mvx044

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regioselective production of sulfated polyphenols using human cytosolic sulfotransferase (SULT)-expressing Escherichia coli cells.2017

    • Author(s)
      Shimohira, T., Kurogi, K., Hashiguchi, T., Liu, M.-C., Suiko, M., Sakakibara, Y.
    • Journal Title

      J. Biosci. Bioeng.

      Volume: - Issue: 1 Pages: 84-90

    • DOI

      10.1016/j.jbiosc.2017.02.006

    • NAID

      40022422358

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity2017

    • Author(s)
      Haruna Takao, Kei Hirabayashi, Yuki Nishigaya, Haruna Kouriki, Tetsuko Nakaniwa, Yoshinori Hagiwara, Jiro Harada, Hideaki Sato, Toshimasa Yamazaki, Yoichi Sakakibara, Masahito Suiko, Yujiro Asada, Yasuhiro Takahashi, Ken Yamamoto, Keiichi Fukuyama, Masakazu Sugishima, and Kei Wada
    • Journal Title

      Nat. Commun.

      Volume: 8 Issue: 1 Pages: 1-10

    • DOI

      10.1038/ncomms14397

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation.2017

    • Author(s)
      Suiko, M., Kurogi, K., Hashiguchi, T., Sakakibara, Y., Liu, M.-C.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 81 Issue: 1 Pages: 63-72

    • DOI

      10.1080/09168451.2016.1222266

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan2016

    • Author(s)
      Yamamoto, A., Kurogi, K., Schiefer, I.T., Liu, M.-Y., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 9 Pages: 1432-1436

    • DOI

      10.1248/bpb.b16-00015

    • NAID

      130005262319

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification and Characterization of the Human Cytosolic Sulfotransferases Mediating the Sulfation of Clioquinol and Iodoquinol2016

    • Author(s)
      Yamamoto, A., Debrah-Pinamang, M., DiModica, N.J., Kurogi, K., Naqvi, A.A., Hui, Y., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Drug Metab. Lett.

      Volume: 10 Pages: 200-205

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 植物硫酸転移酵素の諸性質と今後の展開2016

    • Author(s)
      橋口拓勇, 榊原陽一, 黒木勝久, 水光正仁
    • Journal Title

      日本農薬学会誌

      Volume: 41 Pages: 198-202

    • NAID

      130005402046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel procedure for the assessment of the antioxidant capacity of food components.2016

    • Author(s)
      Yoshimura, T., Harashima, M., Kurogi, K., Suiko, M., Liu, M.-C., Sakakibara, Y.
    • Journal Title

      Anal. Biochem.

      Volume: 507 Pages: 7-12

    • DOI

      10.1016/j.ab.2016.05.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sulfate Conjugation of Daphnetin by the Human Cytosolic Sulfotransferases.2016

    • Author(s)
      Han, Z., Xi, Y., Luo, L., Zhou, C., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      J. Ethnopharmacol.

      Volume: S0378-8741 Pages: 30311-30317

    • DOI

      10.1016/j.jep.2016.05.041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human cytosolic sulfotransferase SULT1C4 mediates the sulfation of doxorubicin and epirubicin.2016

    • Author(s)
      Luo L, Zhou C, Hui Y, Kurogi K, Sakakibara Y, Suiko M, Liu MC.
    • Journal Title

      Drug Metab. Pharmacokinet.

      Volume: 31 Issue: 2 Pages: 163-166

    • DOI

      10.1016/j.dmpk.2016.01.003

    • NAID

      50014431257

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sulfation of Acetaminophen by the Human Cytosolic Sulfotransferases: A Systematic Analysis.2015

    • Author(s)
      Yamamoto, A., Liu, M.-Y., Kurogi, K., Sakakibara, Y., Saeki, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      The Journal of Biochemistry

      Volume: 158 Pages: 497-504

    • DOI

      10.1093/jb/mvv062

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestran by the human cytosolic sulfotransferases (SULTs): A system analysis.2015

    • Author(s)
      Hui, Y., Luo, L., Zhang, L., Kurogi, K., Zhou, C., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 128 Issue: 3 Pages: 144-149

    • DOI

      10.1016/j.jphs.2015.06.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sulfation of 6-Gingerol by the Human Cytosolic Sulfotransferases: A Systematic Analysis.2015

    • Author(s)
      Luo, Y., Mei, X., Xi, Y., Zhou, C., Hui, Y., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Planta Medica

      Volume: 82 Issue: 03 Pages: 238-243

    • DOI

      10.1055/s-0035-1558158

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs)2015

    • Author(s)
      Luo, L., Zhou, C., Kurogi, K., Sakakibara, Y., Suiko, M., Liu, M.-C.
    • Journal Title

      Xenobiotica

      Volume: 46 Issue: 7 Pages: 612-619

    • DOI

      10.3109/00498254.2015.1107656

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis.2015

    • Author(s)
      Zhang L, Kurogi K, Liu MY, Schnapp AM, Williams FE, Sakakibara Y, Suiko M, Liu MC.
    • Journal Title

      J. Appl. Toxicol.

      Volume: none Issue: 9 Pages: 1090-1094

    • DOI

      10.1002/jat.3268

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] シクロペンテノンプロスタグランジン代謝体の受容体を介する作用解析2018

    • Author(s)
      児玉直輝、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コモンマーモセット硫酸転移酵素SULT1Cサブファミリーに関する研究2018

    • Author(s)
      眞鍋曜子、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂質由来α,β-不飽和アルデヒドおよびカルボニル化合物の硫酸化に関する研究2018

    • Author(s)
      黒木勝久、児玉直輝、水光正仁、榊原陽一
    • Organizer
      第42回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食事性タンパク質由来代謝物indoxyl sulfateの好中球細胞酸化促進作用2018

    • Author(s)
      堤秀平、黒木勝久、榊原陽一、水光正仁、安田伸
    • Organizer
      日本農芸化学会2018年度西日本支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小胞体ストレスを軽減する食品成分の探索2017

    • Author(s)
      杉尾里和、下平武彦、神力はるな、永浜清子、近藤知巳、水光正仁、黒木勝久、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥育ホルモン硫酸化活性を有するbovine SULTの同定2017

    • Author(s)
      石川和希、吉瀬仁宣、下平武彦、水光正仁、黒木勝久、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PAPS合成酵素アイソフォームの生理機能解明2017

    • Author(s)
      上中勝護、山下光恵、黒木勝久、上地珠代、剣持直哉、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本プロテオーム学会2017年大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロスタグランジン代謝物のプロスタグランジン受容体への作用解析2017

    • Author(s)
      黒木勝久、榊原陽一、Ming-Cheh Liu、水光正仁
    • Organizer
      日本農芸化学会関西・中四国・西日本支部2017年度合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] PAPS合成酵素アイソフォームの生理機能解明2017

    • Author(s)
      上中勝護、山下光恵、黒木勝久、上地珠代、剣持直哉、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本電気泳動学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preparation and Functions of Regiospecific Sulfated Polyphenols2016

    • Author(s)
      Takehiko Shimohira, Katsuhisa Kurogi, Ming-Cheh Liu, Yoichi Sakakibara, Masahito Suiko
    • Organizer
      YABEC2016
    • Place of Presentation
      Phenix Seagaia Resort (Miyazaki)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体制御分子硫酸体の生理機能評価技術開発2016

    • Author(s)
      下平武彦、黒木勝久、Ming-Cheh Liu、榊原陽一、水光正仁
    • Organizer
      第68回日本生物工学会大会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2016-09-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] ゼブラフィッシュをモデルとしたPAPS合成酵素の生理機能解明2016

    • Author(s)
      上中勝護、上地珠代、剣持直哉、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生体制御分子硫酸体の受容体を介した機能発現メカニズム解明を目指して2016

    • Author(s)
      下平武彦、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      第40回蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Place of Presentation
      指宿ベイテラス(指宿)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sulfation of naphthoquinone and structurally related compounds2016

    • Author(s)
      Yoichi Sakakibara, Tomoki Takeyasu, Katsuhisa Kurogi, Ming-Cheh Liu, Masahito Suiko
    • Organizer
      Conjugation 2016
    • Place of Presentation
      UBC (Vancouver, Canada)
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フラボノイドおよびフラボノイド硫酸体結合タンパク質の探索2016

    • Author(s)
      小川穂乃香、下平武彦、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウシ肝臓膜結合型フェノール硫酸転移酵素の同定2016

    • Author(s)
      吉瀬仁宣、黒木勝久、Ming-Cheh Liu、水光正仁、榊原陽一
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ケトステロイドの代謝機構としての硫酸化2015

    • Author(s)
      橋口拓勇、黒木勝久、Liu, Ming-Cheh、水光正仁、榊原陽一
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(兵庫・神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] PAPS合成酵素アイソフォームの機能解明とその利用2015

    • Author(s)
      上中勝護、黒木勝久、上地珠代、剣持直哉、Liu, Ming-Cheh、水光正仁、榊原陽一
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      城山観光ホテル(鹿児島・鹿児島)
    • Year and Date
      2015-10-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] プロテオミクスによるゼブラフィッシュPAPS合成酵素の機能解明2015

    • Author(s)
      上中勝護、上地珠代、黒木勝久、剣持直哉、Liu, Ming-Cheh、水光正仁、榊原陽一
    • Organizer
      日本農芸化学会2015年度中四国・西日本支部合同大会
    • Place of Presentation
      愛媛大学(愛媛・松山)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト蛋白質チロシン硫酸転移酵素の結晶構造に基づく硫酸化機構解明2015

    • Author(s)
      田中槙之助、西依利晃、古城英貴、坂上功樹、黒木勝久、榊原陽一、水光正仁、木村誠、角田佳充
    • Organizer
      日本農芸化学会2015年度中四国・西日本支部合同大会
    • Place of Presentation
      愛媛大学(愛媛・松山)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 4-Methylumbelliferoneとその硫酸化代謝物による活性酸素産生抑制作用2015

    • Author(s)
      菅原進太郞、小野政輝、井越敬司、黒木勝久、榊原陽一、水光正仁、安田伸
    • Organizer
      2015年度生物機能研究会
    • Place of Presentation
      佐賀大学(佐賀・佐賀)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食品機能性成分硫酸体の受容体を介した機能発現メカニズム解明を目指して2015

    • Author(s)
      下平武彦、黒木勝久、Liu, Ming-Cheh、榊原陽一、水光正仁
    • Organizer
      2015年度生物機能研究会
    • Place of Presentation
      佐賀大学(佐賀・佐賀)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] PAPS合成酵素アイソフォームの生理機能解明2015

    • Author(s)
      上中勝護、黒木勝久、上地珠代、剣持直哉、Liu, Ming-Cheh、水光正仁、榊原陽一
    • Organizer
      2015年度生物機能研究会
    • Place of Presentation
      佐賀大学(佐賀・佐賀)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification and Cheracterization of Vitamin K Sulfotransferase2015

    • Author(s)
      Tomoaki Takeyasu, Katsuhisa Kurogi, Ming-Cheh Liu, Yoichi Sakakibara, Masahito Suiko
    • Organizer
      ICCP450 Tokyo 2015
    • Place of Presentation
      国立オリンピック記念青少年センター(東京・渋谷)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脊椎動物PAPS合成酵素の機能解析2015

    • Author(s)
      上中勝護、黒木勝久、上地珠代、剣持直哉、Liu, Ming-Cheh、榊原陽一、水光正仁
    • Organizer
      平成27年度 日本生化学会九州支部例会
    • Place of Presentation
      九州大学(福岡・福岡)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト蛋白質チロシン硫酸転移酵素1の結晶構造解析2015

    • Author(s)
      田中槙之助、西依利晃、古城英貴、黒木勝久、榊原陽一、水光正仁、木村誠、角田佳充
    • Organizer
      平成27年度 日本生化学会九州支部例会
    • Place of Presentation
      九州大学(福岡・福岡)
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Remarks] 宮崎大学農学部応用生物科学科 生体分子機能化学研究室

    • URL

      http://biochemistrylab.web.fc2.com

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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