| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Turnover of gastrointestinal epithelial cells arrests at fasting, while refeeding induces transient hyperproliferation by the action of lumenal lactate produced by commensal microbiota. In this study, we found that this physiological response of colonocytes to fasting-refeeding was disturbed in high fat diet-fed obese mice, which resulted in the increased risk of carcinogenesis. However, we also showed that manipulation of colonocyte turnover with delivery of lactate into the colon lumen and setting appropriate fasting period was able to reduce colonic inflammation, promote epithelial repair, and reduce the risk of carcinogenesis.
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