Effects of simultaneous deficiency of vitamins C and E on memory, learning behavior, lipid metabolism, aging and age-associated disease
Project/Area Number |
15H04505
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
Ishigami Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | 老化 / 食品 |
Outline of Final Research Achievements |
We established SMP30/αTTP double knockout mice as a novel double-deficient model for both vitamin C and vitamin E. SMP30/αTTP double knockout mice showed impaired cue and context-dependent fear memory if both vitamin C and vitamin E were deficient. Moreover, simultaneous deficiency of vitamin C and E revealed that it affects lipid metabolism in the liver.
|
Report
(4 results)
Research Products
(31 results)
-
-
[Journal Article] Age-related changes of vitamin E: α-tocopherol levels in plasma and various tissues of mice and hepatic α-tocopherol transfer protein2017
Author(s)
Takahashi, K., Takisawa, S., Shimokado, K., Kono, N., Arai, H., Ishigami, A.
-
Journal Title
European Journal of Nutrition
Volume: 印刷中
Pages: 1317-1327
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease, asthma-COPD overlap syndrome and bronchial asthma2017
Author(s)
Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami A.
-
Journal Title
The Clinical Respiratory Journal
Volume: ー
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Journal Article] Deficiency of senescence marker protein 30 exacerbates cardiac injury after ischemia/reperfusion2016
Author(s)
Kadowaki S, Shishido T, Sasaki T, Sugai T, Narumi T, Honda Y, Otaki Y, Kinoshita D, Takahashi T, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Ishigami A, Takeishi Y, Kubota I.
-
Journal Title
International Journal of Molecular Sciences
Volume: 17
Pages: 542-542
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases2016
Author(s)
Shuto T, Kamei S, Nohara H, Fujikawa H, Tasaki Y, Sugahara T, Ono T, Matsumoto C, Sakaguchi Y, Maruta K, Nakashima R, Kawakami T, Suico MA, Kondo Y, Ishigami A, Takeo T, Tanaka KI, Watanabe H, Nakagata N, Uchimura K, Kitamura K, Li JD, Kai H.
-
Journal Title
Scientific Reports
Volume: 6
Pages: 39305-39305
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Two chalcones, 4-hydroxyderricin and xanthoangelol, stimulate GLUT4-dependent glucose uptake through the LKB1/AMP-activated protein kinase signaling pathway in 3T3-L1 adipocytes.2015
Author(s)
Ohta, Mitsuhiro; Fujinami, Aya; Kobayashi, Norihiro; Amano, Akiko; Ishigami, Akihito; Tokuda, Harukuni; Suzuki, Nobutaka; Ito, Fumitake; Mori, Taisuke; Sawada, Morio;
-
Journal Title
Nutr. Res.
Volume: 35(7)
Pages: 618-625
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes.2015
Author(s)
Okada, H., Senmaru, T., Fukui, M., Kondo, Y., Ishigami, A., Maruyama, N., Obayashi, H., Yamazaki, M., Nakamura, N., Hasegawa, G.
-
Journal Title
J. Diabetes. Invest.
Volume: 6
Pages: 35-43
DOI
Related Report
Peer Reviewed
-
[Journal Article] Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance.2015
Author(s)
Jung, K.J., Lee, E.K., Kim, S.J., Song, C.W., Maruyama, N., Ishigami, A., Kim, N.D., Im, D.S,, Yu, B.P., Chung, H.Y.
-
Journal Title
J. Mol. Med.
Volume: 6
Pages: 35-43
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Presentation] Senescence marker protein-30/Superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis.2015
Author(s)
Ishigami, A., Kondo, Y., Masutomi, H., Noda, Y., Ozawa, Y., Takahashi, K., Maruyama, N., Shimizu, T.
Organizer
The 10th IAGG Asia/Oceania Regional Congress (IAGG 2015)
Place of Presentation
The International Convention and Exhibition Centre, Chiang Mai, Thailand
Year and Date
2015-10-19
Related Report
Int'l Joint Research
-
-
-
-
-