| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Outline of Final Research Achievements |
Wood rotting fungi have been considered to cause the reduction in wood strength. Since this leads to a significant increase of the risk of collapse in wood structures, wood preservatives are used to prevent the phenomenon. Recently, the development of the wood preservatives with a low environmental burden are required in response to growing attention to environmental consideration.
We focused the fact that fungal pyranose dehydrogenase (PDH), which has been considered to work in the degradation of plant cell wall, uses pyrroloquinoline quinone (PQQ), which is provided from bacteria, as a cofactor. In the present study, inhibitor for PQQ-binding in PDH was selected, and its potential as a wood preservatives was evaluated.
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