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Improving the tolerance to heat stress in animals through integrating control of host and gut microbiota with improved feed ingredients

Research Project

Project/Area Number 15H04582
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

TOYOMIZU Masaaki  東北大学, 農学研究科, 教授 (80180199)

Co-Investigator(Kenkyū-buntansha) 大塚 彰  鹿児島大学, 農水産獣医学域農学系, 教授 (10233173)
陶山 佳久  東北大学, 農学研究科, 准教授 (60282315)
喜久里 基  東北大学, 農学研究科, 准教授 (90613042)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsストレス制御 / タンパク質分解制御 / 免疫能制御 / 腸内細菌叢制御 / アナカルド酸 / 暑熱ストレス / 胸腺 / インターロイキン6 / エネルギー代謝 / 免疫変化 / 腸内細菌叢
Outline of Final Research Achievements

The objectives of this research are to clarify the mechanism underlying decreasing body weight and feed efficiency in broiler chickens exposed to heat stress, and to develop feed ingredients to improve the reduced performance. Heat exposure to chickens was found to induce increased proteolysis of skeletal muscles via more mitochondrial ROS generation and decreased CD3-positive cell in the spleen so that metabolic and immune systems remarkably enhance energy requirement to maintain homeostasis. Streptococcus appears to be the less dominant genus in the ileum of heat-stressed chickens. Feeding diets supplemented with cashew nut shell liquid (CNSL) causes broiler chicken to alleviate reductions of body weight and feed intake when exposed to heat, partially via control of intestinal immune-related gene expression.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (28 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results)

  • [Journal Article] Characterization of Mitochondrial Content and Respiratory Capacities of Broiler Chicken Skeletal Muscles with Different Muscle Fiber Compositions2018

    • Author(s)
      1.Hakamata, Y., Watanabe, K., Amo, T., Toyomizu, M. and Kikusato, M.
    • Journal Title

      The Journal of Poultry Science

      Volume: 55 Issue: 3 Pages: 210-216

    • DOI

      10.2141/jpsa.0170141

    • NAID

      130007419002

    • ISSN
      1346-7395, 1349-0486
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of trehalose supplementation on the growth performance and intestinal innate immunity of juvenile chicks2016

    • Author(s)
      M. Kikusato, F. Nanto, K. Mukai and M. Toyomizu
    • Journal Title

      British Poultry Science

      Volume: in press Issue: 3 Pages: 375-80

    • DOI

      10.1080/00071668.2016.1166475

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α2016

    • Author(s)
      Kikusato, M., Muroi, M., Uwabe, Y., Furukawa,K., and Toyomizu, M.
    • Journal Title

      Animal Science Journal

      Volume: 87 Issue: 11 Pages: 1371-1378

    • DOI

      10.1111/asj.12559

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The suppressive effect of dietary coenzyme Q10 on mitochondrial ROS production and oxidative stress in chickens exposed to heat stress2016

    • Author(s)
      Kikusato, M., Nakamura, K., Mikami, Y., Mujahid, A. and Toyomizu, M.
    • Journal Title

      Animal Science Journal

      Volume: 87 Issue: 10 Pages: 1244-1251

    • DOI

      10.1111/asj.12543

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-course changes in muscle protein degradation in heat-stressed chickens: Possible involvement of corticosterone and mitochondrial reactive oxygen species generation in induction of the ubiquitin-proteasome system2016

    • Author(s)
      Furukawa, K. Kikusato, M., Kamizono, T. and Toyomizu, M.
    • Journal Title

      General and Comparative Endocrinology

      Volume: 228 Pages: 105-110

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of feeding diets combining whole-grain paddy rice and high levels of fat on broiler chicken growth2016

    • Author(s)
      Nanto, F., Ito, C., Kikusato, M. and Toyomizu, M.
    • Journal Title

      The Journal of Poultry Science

      Volume: 53 Pages: 34-39

    • NAID

      130005120954

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Differences in mitochondrial fatty acid utilization and respiratory complex characteristics between meat-type and laying-type chickens2018

    • Author(s)
      Hakamata, Y., Amo, T., Toyomizu, M., Kikusato, M
    • Organizer
      11th Asia Pacific Poultry Conference (APPC2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 飼料中トウモロコシ粒度が肉用鶏の成長・消化管におよぼす影響2018

    • Author(s)
      松橋花菜子・渡邊康一・豊水正昭・喜久里基
    • Organizer
      日本家禽学会2018年春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肉用鶏へのアナカルド酸給与時におけるその動態と腸内細菌叢の解析2018

    • Author(s)
      永津健太郎・Md.Abul Kalam Azad・南都文香・古川恭平・平川良太・喜久里基・豊水正昭
    • Organizer
      日本家禽学会2018年春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 暑熱環境が肉用鶏のリンパ組織に及ぼす影響2018

    • Author(s)
      平川良太、野地智法、喜久里基、古川恭平、村井篤嗣、豊水正昭
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Decreased Glycolysis Relates to Immune Response in Heat-Stressed Chicken2017

    • Author(s)
      Nurjanah Siti・野地智法・南都文香・古川恭平・阿部汐里・福田栞・喜久里基・豊水正昭
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 寒冷曝露および甲状腺ホルモン給与はニワトリ脂肪組織のベージュ化を誘導するか2017

    • Author(s)
      五月女里梨・喜久里基・南都文香・平澤明・豊水正昭
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生理的濃度のコルチコステロンはニワトリ高温培養筋細胞のタンパク質分解を増強しない2017

    • Author(s)
      古川恭平・喜久里基・豊水正昭
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Oleuropein suppresses oxidative damage in avian skeletal muscle, possibly via SIRT1 up-regulation2017

    • Author(s)
      Kikusato, M., Shimao, R., Muroi, H. and Toyomizu, M.
    • Organizer
      21st European Symposium on Poultry Nutrition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 飼料用米給与は暑熱感作時の肉用鶏の生産性に影響するか2017

    • Author(s)
      近藤あずさ・南都文香・喜久里基・豊水正昭
    • Organizer
      日本家禽学会2017年度春季大会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] オリーブ特有フェノール化合物オレウロペインがニワトリ骨格筋の活性酸素産生におよぼす影響2017

    • Author(s)
      室井ひかる・嶋尾里紗・神園巴美・豊水正昭・喜久里基
    • Organizer
      日本家禽学会2017年度春季大会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mitochondrial function and chicken performance2016

    • Author(s)
      Toyomizu, M.
    • Organizer
      中国畜牧獣医学会
    • Place of Presentation
      武漢 (中国)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Roles of corticosterone and superoxide in the ubiquitin proteasome system in heat-stressed chickens2016

    • Author(s)
      Furukawa, K., Kikusato, M., Toyomizu, M.
    • Organizer
      5th EAAP International Symposium on Energy and Protein Metabolism and Nutrition ISEP2016
    • Place of Presentation
      Krakow(ポーランド)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparisons of reactive oxygen species regulation in skeletal muscle with different muscle fiber compositions from heat-stressed birds2016

    • Author(s)
      Kikusato, M., Toyomizu, M.
    • Organizer
      5th EAAP International Symposium on Energy and Protein Metabolism and Nutrition ISEP2016
    • Place of Presentation
      Krakow(ポーランド)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Possible mechanism of down-regulation of atrogin-1 mRNA level in butoxybutyl alcohol-fed chicken2016

    • Author(s)
      Kamizono, T., Kikusato, M., Hayashi, K., Toyomizu, M.
    • Organizer
      5th EAAP International Symposium on Energy and Protein Metabolism and Nutrition ISEP2016
    • Place of Presentation
      Krakow(ポーランド)
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of mitochondrial oxidative phosphorylation and reactive oxygen species generation in the metaboric modification of avian skeletal muscle.2016

    • Author(s)
      Motoi Kikusato, Kyohei Furukawa, Tomomi Kamizono, Yuki Hakamata and Masaaki Toyomizu
    • Organizer
      The 17th Animal Science Congress of AAAP
    • Place of Presentation
      九州産業大学(福岡県・福岡市)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time-course of changes in muscle antioxidant peptide concentrations in heat-stressed broiler chickens2016

    • Author(s)
      Kyohei FURUKAWA, Natsumi WAKI, Motoi KIKUSATO, Akane ASHIHARA, Aiko ISHIDA, Kazuki NAKASHIMA and Masaaki TOYOMIZU1
    • Organizer
      The 17th Animal Science Congress of AAAP
    • Place of Presentation
      九州産業大学(福岡県・福岡市)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Defining the mitochondrial histochemical characteristics of avian skeletal muscles with different muscle fiber type compositions2016

    • Author(s)
      Yuki HAKAMATA, Motoi KIKUSATO, Kouichi WATANABE, Taku AMO and Masaaki TOYOMIZU
    • Organizer
      The 17th Animal Science Congress of AAAP
    • Place of Presentation
      九州産業大学(福岡県・福岡市)
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 暑熱負荷鶏の浅胸筋および腓腹筋におけるミトコンドリア活性酸素産生制御の比較解析2016

    • Author(s)
      喜久里基・豊水正昭
    • Organizer
      日本家禽学会2016年春季大会
    • Place of Presentation
      日本獣医生命科学大学(東京都武蔵野市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 飼料用米給与時における鶏の暑熱感作応答2016

    • Author(s)
      南都文香・近藤あずさ・喜久里基・松木悠・陶山佳久・森田英利・豊水正昭
    • Organizer
      日本畜産学会第121回大会
    • Place of Presentation
      日本獣医生命科学大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 段階的暑熱環境下における肉用鶏の酸化ストレスに対するコエンザイムQ10(CoQ10)の抑制作用2016

    • Author(s)
      三上由紀子・喜久里基・豊水正昭
    • Organizer
      日本畜産学会第121回大会
    • Place of Presentation
      日本獣医生命科学大学(東京都武蔵野市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ニワトリ筋細胞におけるオレウロペインのPGC-1α発現誘導作用がミトコンドリア生合成・活性酸素産生におよぼす影響2015

    • Author(s)
      室井ひかる・喜久里基・上部雄一郎・古川恭平・豊水正昭
    • Organizer
      日本畜産学会第120回大会
    • Place of Presentation
      酪農学園大学(北海道江別市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] エネルギー源の異なる高代謝エネルギー(ME)飼料が肉用鶏の飼養成績および肉質におよぼす影響2015

    • Author(s)
      近藤あずさ・南都文香・喜久里基・豊水正昭
    • Organizer
      日本家禽学会2015年秋季大会
    • Place of Presentation
      酪農学園大学(北海道江別市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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