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Functional properties of Leucine-peptides derived from meat proteins

Research Project

Project/Area Number 15H04587
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal production science
Research InstitutionKitasato University

Principal Investigator

ARIHARA KEIZO  北里大学, 獣医学部, 教授 (00175994)

Research Collaborator OHATA MOTOKO  日本大学, 生物資源科学部, 講師
KOMIYA YUSUKE  北里大学, 獣医学部, 助教
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords食肉 / ペプチド / ロイシン / 抗酸化作用 / メイラード反応 / 食品 / 保健的機能
Outline of Final Research Achievements

Leucine-dipeptides were paid attention to study their functionalities and develop their industrial applications. Of 19 Leucine-dipeptides tested in this study, dipeptides containing Alanine, Arginine, or Lysine showed high antioxidative activities. In addition, Maillard reaction products generated from Leucine-dipeptides containing Arginine or Lysine increased their activities significantly. Orally administrated these materials with high activities decreased oxidative stress in animal bodies. Leucine-dipeptides, such as Leucine-Lysine and Lysine-Leucine would contribute to the prevention of atrophy of skeletal muscle associated with aging. From the results of this study along with previous observations, Leucine-dipeptides and their Maillard reaction products have important roles in meat and great possibility in the food industry.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015 Other

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Book (7 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Functionality and capability of odorants generated by the Maillarad reaction in foods2018

    • Author(s)
      Ohata M, Yokoyama I, Arihara K
    • Journal Title

      International Maillard Reaction Society Highlights

      Volume: 13 Pages: 9-16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食品としての油脂が骨格筋の代謝特性へ与える影響と筋線維タイプとの関連2018

    • Author(s)
      小宮佑介, 丸山アレクサンデル, 渡辺裕介, 内田直愛, 大津翔平, 小林千亜暉, 横山壱成, 鈴木貴弘, 中村真子, 辰巳隆一, 池内義秀, 水野谷航, 有原圭三
    • Journal Title

      家畜栄養生理研究会報

      Volume: 58 Pages: 9-17

    • NAID

      40021510398

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odors generated from the Maillard reaction affect autonomic nervous activity and decrease blood pressure through the olfactory system2017

    • Author(s)
      Zhou L, Ohata M, Owashi C, Nagai K, Yokoyama I, Arihara K
    • Journal Title

      Journal of Science of Food and Agriculture

      Volume: 97 Issue: 3 Pages: 923-927

    • DOI

      10.1002/jsfa.8538

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of two novel antioxidant peptides from edible bird’s (Aerodramus fuciphagus) nest protein using digestive proteases2017

    • Author(s)
      Ghassem M, Arihara K, Mohammadi S, Sani N, Babji AS
    • Journal Title

      Food and Function

      Volume: in press Issue: 5 Pages: 2046-2052

    • DOI

      10.1039/c6fo01615d

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Bioactive properties of Maillard reaction products generated from food protein-derived peptides2017

    • Author(s)
      Arihara K, Zhou L, Ohata M
    • Journal Title

      Advances in Food and Nutrition Research

      Volume: 81 Pages: 161-181

    • DOI

      10.1016/bs.afnr.2016.11.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Investigation of volatile components and identification of the most potent odor-active component in fermented meat sauce2017

    • Author(s)
      Ohata M, Zhou L, Higuchi K, Nagai T, Kasamatsu H, Arihara K
    • Journal Title

      Flavour and Fragnance journal

      Volume: in press Issue: 3 Pages: 171-177

    • DOI

      10.1002/ffj.3371

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 食品・ペットフード・化粧品における機能性ペプチドの利用2016

    • Author(s)
      有原圭三, 小宮佑介
    • Journal Title

      月刊ファインケミカル

      Volume: 45 (9) Pages: 5-14

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 機能性食品素材としての乳・肉・卵の可能性2016

    • Author(s)
      有原圭三, 小宮佑介
    • Journal Title

      月刊FOOD Style 21

      Volume: 20 (11) Pages: 46-49

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Effects of odor generated from the glycine/glucose Maillard reaction on human mood and brainwaves2016

    • Author(s)
      Zhou L, Ohata M, Arihara K
    • Journal Title

      Food and function

      Volume: 未定 Issue: 6 Pages: 2574-2581

    • DOI

      10.1039/c5fo01546d

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin converting enzyme inhibitory and antihypertensive activities of protein hydrolysate from meat of Kacang goat2016

    • Author(s)
      Mirdhayati I, Hermanianto J, Wijaya CH, Sajuthi D, Arihara K
    • Journal Title

      Journal of Science of Food and Agriculture

      Volume: 未定 Issue: 10 Pages: 3536-3542

    • DOI

      10.1002/jsfa.7538

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antioxidant activity of fermented meat sauce and isolation of an associated antioxidant peptide2016

    • Author(s)
      Ohata M, Uchida S, Zhou L, Arihara K.
    • Journal Title

      Food Chemistry

      Volume: 194 Pages: 1034-1039

    • DOI

      10.1016/j.foodchem.2015.08.089

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] メイラード反応生成香気曝露が脳内遺伝子発現に及ぼす影響2018

    • Author(s)
      横山壱成, 中井雄二, 鈴木喜博, 大畑素子, 小宮佑介, 有原圭三
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リジン由来メイラード反応生成物の抗酸化作用および抗健忘作用2018

    • Author(s)
      柴宮大輔, 小宮佑介, 有原圭三
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メイラード反応により生成するDMHF香気は食欲を増進させる2018

    • Author(s)
      横山壱成, 中井雄二, 鈴木喜博, 大畑素子, 小宮佑介, 有原圭三
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ロイシンジペプチドおよびそのメイラード反応生成物の抗酸化作用2017

    • Author(s)
      大畑麻奈, 小宮佑介, 有原圭三
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県神戸市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルギニンおよびリジンに由来するメイラード反応生成香気の血圧への影響2017

    • Author(s)
      横山壱成, 周蘭西, 大畑素子 有原圭三
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸大学(兵庫県神戸市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食品のメイラード反応で生成する香気がヒトに及ぼす生理作用2017

    • Author(s)
      大畑素子,周蘭西,矢田幸博, 有原圭三
    • Organizer
      第23回日本行動医学会総会
    • Place of Presentation
      沖縄科学技術大学院大学(沖縄県国頭郡)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルギニンおよびリジン由来のメイラード反応生成物の抗健忘作用2017

    • Author(s)
      柴宮大輔, 横山譲, 小宮佑介, 有原圭三
    • Organizer
      東北畜産学会第67回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルギニンと還元糖の加熱により生成する香気の血圧降下作用2017

    • Author(s)
      横山壱成, ,小宮佑介, 有原圭三
    • Organizer
      東北畜産学会第67回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鶏肉タンパク質由来のペプチドやそのメイラード反応生成物によるペット用療法食の嗜好性向上2017

    • Author(s)
      服部美咲, 小宮佑介, 有原圭三
    • Organizer
      東北畜産学会第67回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Probiotics and bioactive peptides for developing functional foods2017

    • Author(s)
      Arihara K
    • Organizer
      Scientific Symposium of Orel Agrican University
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] メイラード反応を利用した保健的機能性と嗜好性向上作用を備えた食品素材2017

    • Author(s)
      有原圭三
    • Organizer
      Bio tech 2017 第14回アカデミックフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鶏肉タンパク質分解物の嗜好性に対する影響2016

    • Author(s)
      飯田雅, 大畑素子, 有原圭三
    • Organizer
      日本畜産学会第121回大会
    • Place of Presentation
      日本獣医生命科学大学(東京都武蔵野市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペプチドの特性を生かした美味しくて体に良い食品の開発2016

    • Author(s)
      有原圭三
    • Organizer
      弘前大学農学生命科学部地域資源利活用センターシンポジウム
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Bioactive peptides and probiotics for functional meat products2015

    • Author(s)
      Arihara K
    • Organizer
      Conference for 85th Anniversary of the All-Russian Meat Research Institute
    • Place of Presentation
      Moscow, Russia
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional properties of peptides in foods and development of peptide-based food ingredients2015

    • Author(s)
      Arihara K
    • Organizer
      Symposium on Chemistry and Biotechnology of Functional Foods and Renewable Natural Resources
    • Place of Presentation
      Ulaanbaatar, Mongolia
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Advanced Technologies for Meat Processing (2nd edition)2018

    • Author(s)
      Arihara K, Komiya Y
    • Total Pages
      32
    • Publisher
      CRC Press
    • Related Report
      2017 Annual Research Report
  • [Book] CRC Press2017

    • Author(s)
      Arihara K, Ohata M
    • Total Pages
      16
    • Publisher
      Advances in Meat Processing Technology
    • Related Report
      2017 Annual Research Report
  • [Book] Advanced Technologies for Meat Processing (2nd edition)2017

    • Author(s)
      Arihara K, Komiya Y
    • Total Pages
      20
    • Publisher
      CRC Press
    • Related Report
      2016 Annual Research Report
  • [Book] Advances in Meat Processing Technology2017

    • Author(s)
      Arihara K, Ohata M
    • Total Pages
      16
    • Publisher
      CRC Press
    • Related Report
      2016 Annual Research Report
  • [Book] メイラード反応の機構・制御・利用2016

    • Author(s)
      有原圭三
    • Total Pages
      8
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] Advanced Meat Processing2016

    • Author(s)
      Arihara K
    • Total Pages
      18
    • Publisher
      CRC Press
    • Related Report
      2015 Annual Research Report
  • [Book] 機能性ペプチドの開発最前線2015

    • Author(s)
      有原圭三
    • Total Pages
      36
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Remarks] 北里大学獣医学部食品機能安全学研究室

    • Related Report
      2017 Annual Research Report
  • [Remarks] 北里大学獣医学部食品機能安全学研究室

    • URL

      http://www.food-kitasato.jp/

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] DMHFを含むリラックス剤2017

    • Inventor(s)
      大畑素子・横山壱成・有原圭三
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-142580
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] メイラード反応を利用して機能性を強化した素材およびこれを用いた食品・ペットフード2016

    • Inventor(s)
      有原圭三, 大畑素子
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-233792
    • Filing Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] アミノ酸を原料とする嗜好性と保健的機能性に優れた素材 およびこれを 利用した食品・ペットフード2015

    • Inventor(s)
      有原圭三, 大畑素子
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-06-18
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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