Identification of Neospora virulence factor and its application for the vaccine development
| Project/Area Number |
15H04589
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IGARASHI Makoto 帯広畜産大学, 原虫病研究センター, 教授 (60374766)
KURODA Yasuhiro 東海大学, 工学部, 准教授 (40398756)
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| Research Collaborator |
IHARA Fumiaki
Ragab Fereig
Arpron Leesombun
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 感染症 / ワクチン / 免疫 / 畜産 / ネオスポラ / 免疫学 |
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| Outline of Final Research Achievements |
In this study, we aimed at identifying virulence factors of Neoospora caninum, which induces reproductive disorders in livestock, and its application for the vaccine development. Because excess inflammatory response may be involved in pathogenicity, screening of Neospora molecules activating host signaling of immune responses was performed. The activating factor-deficient parasites lost the virulence in mice. Furthermore, vaccines based on the activating factor induced protective immune responses. With no effective drugs or vaccines available to control neosporosis, our results will be valuable for the future vaccine development.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] A clinical case of neosporosis in a 4-week-old holstein friesian calf which developed hindlimb paresis postnatally2018
Author(s)
Uesaka, K., Koyama, K., Horiuchi, N., Kobayashi, Y., Nishikawa, Y. and Inokuma H.
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Journal Title
Journal of Veterinary Medical Science
Volume: 80
Issue: 2
Pages: 280-283
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access
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[Journal Article] In vitro and in vivo effects of the phytohormone inhibitor fluridone against Neospora caninum infection2016
Author(s)
bañez, R.H., Leesombun, A., Nishimura, M., Matsubara, R., Kojima, M., Sakakibara, H., Nagamune, K., Nishikawa, Y.
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Journal Title
Parasitol. Int.
Volume: 65
Issue: 4
Pages: 319-322
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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