The role of canine AIM in histiocytic sarcoma
| Project/Area Number |
15H04590
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yonezawa Tomohiro 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)
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| Co-Investigator(Kenkyū-buntansha) |
松木 直章 東京大学, 大学院農学生命科学研究科(農学部), 教授 (40251417)
盆子原 誠 日本獣医生命科学大学, 獣医学部, 教授 (50343611)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | マクロファージ / 組織球性肉腫 / 犬 / イヌ / 腫瘍 / ヌードマウス / アポトーシス / 獣医学 / 癌 / 免疫 / がん / AIM / CD5L |
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| Outline of Final Research Achievements |
Histiocytic sarcoma, macrophage-derived tumor is seriously malignant and therapeutic method is not established. In this study, we focused on apoptosis inhibitor of macrophage (AIM). It is found that AIM is expressed in several normal tissues and histiocytic tumors. When AIM expression vector was transfected into histiocytic cell lines, the cell number was reduced. Canine recombinant AIM also could induce apoptosis of these cells. It is suggested canine AIM has apoptotic inducing effect in histiocytic sarcoma.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Relationship between lunar cycle and spontaneous delivery date in Holstein cows2017
Author(s)
Tomohiro Yonezawa, Dai Ishiyama, Mona Uchida, Michiko Tomioka, Kazunori Ishii, Shizuko Maeda, Yoji Sasai, Masatsugu Asada, Tadashi Kawamura, Yoshihiro Nakamura, Eimei Sato, Shingo Maeda, Naoaki Matsuki
Organizer
WCRB2017
Related Report
Int'l Joint Research
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