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The role of canine AIM in histiocytic sarcoma

Research Project

Project/Area Number 15H04590
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Yonezawa Tomohiro  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (10433715)

Co-Investigator(Kenkyū-buntansha) 松木 直章  東京大学, 大学院農学生命科学研究科(農学部), 教授 (40251417)
盆子原 誠  日本獣医生命科学大学, 獣医学部, 教授 (50343611)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywordsマクロファージ / 組織球性肉腫 / 犬 / イヌ / 腫瘍 / ヌードマウス / アポトーシス / 獣医学 / 癌 / 免疫 / がん / AIM / CD5L
Outline of Final Research Achievements

Histiocytic sarcoma, macrophage-derived tumor is seriously malignant and therapeutic method is not established. In this study, we focused on apoptosis inhibitor of macrophage (AIM). It is found that AIM is expressed in several normal tissues and histiocytic tumors. When AIM expression vector was transfected into histiocytic cell lines, the cell number was reduced. Canine recombinant AIM also could induce apoptosis of these cells. It is suggested canine AIM has apoptotic inducing effect in histiocytic sarcoma.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(22 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Moffitt cancer center(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Presence of contagious yawning in sheep2018

    • Author(s)
      Yonezawa Tomohiro、Sato Kohei、Uchida Mona、Matsuki Naoaki、Yamazaki Atusi
    • Journal Title

      Anim Sci J.

      Volume: 88 Pages: 195-200

    • DOI

      10.1111/asj.12681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased plasma amino acid concentrations in cats with chronic gastrointestinal diseases and their possible contribution in the inflammatory response.2018

    • Author(s)
      Sakai K, Maeda S, Yonezawa T, Matsuki N.
    • Journal Title

      Veterinary Immunology and Immunopathology

      Volume: 195 Pages: 1-6

    • DOI

      10.1016/j.vetimm.2017.11.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fecal microbiome in dogs with inflammatory bowel disease and intestinal lymphoma2017

    • Author(s)
      Omori M, Maeda S, Igarashi H, Ohno K, Sakai K, Yonezawa T, Horigome A, Odamaki T, Matsuki N
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 79(11) Issue: 11 Pages: 1840-1847

    • DOI

      10.1292/jvms.17-0045

    • NAID

      130006206562

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Density of tumor-infiltrating granzyme B-positive cells predicts favorable prognosis in dogs with transitional cell carcinoma2017

    • Author(s)
      Inoue Akiko、Maeda Shingo、Kinoshita Ryohei、Tsuboi Masaya、Yonezawa Tomohiro、Matsuki Naoaki
    • Journal Title

      Veterinary Immunology Immunopathology

      Volume: 190 Pages: 53-56

    • DOI

      10.1016/j.vetimm.2017.07.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic Cytology for the Diagnosis of Chronic Enteritis and Intestinal Lymphoma in Dogs2017

    • Author(s)
      Maeda S.、Tsuboi M.、Sakai K.、Ohno K.、Fukushima K.、Kanemoto H.、Hiyoshi-Kanemoto S.、Goto-Koshino Y.、Chambers J. K.、Yonezawa T.、Uchida K.、Matsuki N.
    • Journal Title

      Vet Pathol.

      Volume: 54 Pages: 595-604

    • DOI

      10.1177/0300985817705175

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cycle Influences Spontaneous Delivery in Cows.2016

    • Author(s)
      Yonezawa T, Uchida M, Tomioka M, Matsuki N
    • Journal Title

      PLoS One

      Volume: 11(8)

    • DOI

      10.1371/journal.pone.0161735

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Apoptosis inhibitor of macrophage (AIM) reduces cell number in canine histiocytic sarcoma cell lines2016

    • Author(s)
      Uchida M, Saeki K, Maeda S, Tamahara S, Yonezawa T, Matsuki N
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 78(9) Issue: 9 Pages: 1515-1520

    • DOI

      10.1292/jvms.16-0120

    • NAID

      130005598036

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prolactin suppression of Gonadotropin releasing hormone initiation of mammary gland involution in female rats.2016

    • Author(s)
      Rieanrakwong D, Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Hasegawa Y, Kawaminami M.
    • Journal Title

      Endocrinology

      Volume: 157(7) Pages: 2750-2758

    • DOI

      10.1210/en.2016-1180

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synovial fluid matrix metalloproteinase-2 and -9 activities in dogs suffering from joint disorders2016

    • Author(s)
      Murakami K, Maeda S, Yonezawa T, Matsuki N
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 78(6) Issue: 6 Pages: 1051-1054

    • DOI

      10.1292/jvms.15-0711

    • NAID

      130005159665

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gonadotropin-releasing hormone is prerequisite for the constitutive expression of pituitary annexin A52015

    • Author(s)
      Yonezawa T, Watanabe A, Kurusu S, Kawaminami M.
    • Journal Title

      Endocr J

      Volume: 62(12) Issue: 12 Pages: 1127-1132

    • DOI

      10.1507/endocrj.ej15-0410

      10.1507/endocrj.EJ15-0410

    • NAID

      130005115210

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer.2015

    • Author(s)
      Yonezawa T, Chen KH, Ghosh MK, Rivera L, Dill R, Ma L, Villa PA, Kawaminami M, Walker AM
    • Journal Title

      Cancer Lett.

      Volume: 366 Pages: 84-92

    • DOI

      10.1016/j.canlet.2015.06.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Augmentation of Metastin/Kisspeptin mRNA Expression by the Proestrous Luteinizing Hormone Surge in Granulosa Cells of Rats: Implications for Luteinization.2015

    • Author(s)
      Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Kawaminami M.
    • Journal Title

      Biol Reprod.

      Volume: 93 Pages: 1-9

    • DOI

      10.1095/biolreprod.115.127902

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alteration of somatostatin receptor 2 expression in canine mammary gland tumor2015

    • Author(s)
      Sakai K, Yonezawa T, Yamawaki H, Oyamada T.
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77(10) Issue: 10 Pages: 1319-1322

    • DOI

      10.1292/jvms.15-0002

    • NAID

      130005107591

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Syngeneic ANXA5 inhibition of mammary tumor cell growth in the dog2017

    • Author(s)
      Mona Uchida, Kohei Saeki, Shingo Maeda, Tomohiro Yonezawa, Naoaki Matsuki and Mitsumori Kawaminami
    • Organizer
      Annexin Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between lunar cycle and spontaneous delivery date in Holstein cows2017

    • Author(s)
      Tomohiro Yonezawa, Dai Ishiyama, Mona Uchida, Michiko Tomioka, Kazunori Ishii, Shizuko Maeda, Yoji Sasai, Masatsugu Asada, Tadashi Kawamura, Yoshihiro Nakamura, Eimei Sato, Shingo Maeda, Naoaki Matsuki
    • Organizer
      WCRB2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Down-regulation of Annexin A5 (ANXA5) expression in canine mammary tumor cells and a possibility of therapeutic application of ANXA52015

    • Author(s)
      Mona Uchida, Kosei Sakai, Tomohiro Yonezawa, Mitsumori Kawaminami
    • Organizer
      Annexin Conference 2015
    • Place of Presentation
      Maastricht, Netherland
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptosis inhibitor of macrophage in dog: molecular characterization and inhibitory effect on histiocytic sarcoma cell proliferation in vitro2015

    • Author(s)
      Mona Uchida, Shintaro Tomura, Kohei Saeki, Shingo Maeda, Satoshi Tamahara, Tomohiro Yonezawa, Naoaki Matsuki
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages 2015
    • Place of Presentation
      東京大学
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Apoptosis inhibitor of macrophage (AIM)がイヌ組織球性肉腫株化細胞にもたらす影響2015

    • Author(s)
      内田萌菜、米澤智洋、佐伯亘平、盆子原誠、前田真吾、松木直章
    • Organizer
      獣医臨床病理学会2015年大会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] イヌ乳腺腫瘍におけるアネキシンA5(Anxa5)の発現2015

    • Author(s)
      内田萌菜、酒居幸生、米澤智洋、汾陽光盛
    • Organizer
      第1回日本アネキシン研究会
    • Place of Presentation
      東京大学
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 腫瘍の治療剤およびその使用2016

    • Inventor(s)
      米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
    • Industrial Property Rights Holder
      米澤智洋、内田萌菜、松木直章、金村優香、川上和夫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] Therapeutic agent for tumor derived from immune cells and use thereof2015

    • Inventor(s)
      Tomohiro Yonezawa et al
    • Industrial Property Rights Holder
      Tomohiro Yonezawa et al
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Overseas

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Published: 2015-04-16   Modified: 2022-10-07  

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