| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
To control rabies, lethal viral zoonotic disease, experimental and pathological studies were performed, especially brain histopathology and CSF analysis were examined. It is showed that rabies viruses were eliminated from the brain and not induce lethal infection when viral neutralizing antibodies were produced in blood and CSF in high level. Further, the antigen-specific antibodies in CSF were produced in deep cervical lymph nodes, and brain dura matter might be involved in cerebral immune responses. Apolipoprotein A-1 in CSF was detected after rabies virus infection, as one of the small compositional changes in CSF.
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