Systems biology analysis of the pathogenesis of kidney injury caused by deficiency of a water channel protein localized in the endoplasmic reticulum
| Project/Area Number |
15H04594
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Research Collaborator |
ISHIBASHI Kenichi
MATSUZAKI Toshiyuki
SONODA Hiroko
YOKOTA-IKEDA Naoko
NAGANOBU Kiyokazu
TORISU Shidow
KANEKO Yasuyuki
TAKAHASHI Saki
OSHIKAWA Sayaka
MIKODA Nobuyuki
ASVAPROMTADA Siree
HOSHINO Yuya
SINLAPADEELERDKUL Thitaporn
KATO Ayaka
KINOUCHI Minami
KOGA Moeko
KISHABA Ai
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | アクアポリン-11 / systems biology / 小胞体 / NOX2 / 酸化ストレス / アポトーシス / アクアポリン / AQP11 / システム生物学 / 活性酸素 / 薬理学 |
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| Outline of Final Research Achievements |
Aquaporin-11 (AQP11), a member of a family of transmembrane channel proteins, is known to be localized in the endoplasmic reticulum. So far, studies with AQP11-deficient mice have suggested that loss of function of AQP11 caused kidney injury, characterized by formation of cysts. However, the mechanism underlying the kidney injury remains unclear. In this study, in order to clarify the mechanism, we examined the kidneys from AQP11-deficient mice using systems biology. Finally, we found that the pathway of NADPH oxidase 2 (NOX2) - reactive oxygen species - apoptosis might be involved in the AQP11-deficient-induced kidney injury.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Acetazolamide enhances the release of urinary exosomal2016
Author(s)
Abdeen, A., Sonoda, H., Oshikawa, S., Hoshino, Y., Kondo, H., Ikeda, M.
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Journal Title
Nephrol. Dial. Transplant.
Volume: in press
Issue: 10
Pages: 1623-1632
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Arterial blood gas anomaly in canine hepatobiliary disease2015
Author(s)
Kaneko, Y., Torisu, S., Kobayashi, T., Mizutani, S., Tsuzuki, N., Sonoda, H., Ikeda, M., Naganobu, K.
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Journal Title
Journal of Veterinary Medical Science
Volume: 77
Issue: 12
Pages: 1633-1638
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed
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