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The etiology and pathology on avian myeloid leukosis-like lesions recently observed in Japan

Research Project

Project/Area Number 15H04597
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Veterinary medical science
Research InstitutionIwate University

Principal Investigator

Goryo Masanobu  岩手大学, 農学部, 教授 (80153774)

Co-Investigator(Kenkyū-buntansha) 畑井 仁  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (40566535)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsトリ白血病 / トリレトロウイルス / 骨化石症 / 粘液肉腫 / 神経膠腫 / トリ白血病ウイルス / グリオーマ / 分子系統進化 / 骨髄性白血病 / リンパ性白血病
Outline of Final Research Achievements

Recently, avian myeloid leukosis (ML)-like lesions have been observed in broilers in Okinawa, Japan. The birds kept with the affected boilers were examined to clarify the relationship between avian leukosis viruses (ALVs). Although there was accumulation of myelocytes in the livers of examined birds, ALV was not isolated from these livers. The ML-like lesions are considered as severe hepatic extramedullary hematopoiesis in broilers. Secondly, mesenchymal neoplasms and osteopetrosis in a dual purpose breed for meat and eggs were examined. These birds were currently affected with fowl glioma. Nucleotide sequencing of the env gene suggests that four ALV isolates (GifN strains) are novel recombinant viruses. In addition, experimental infection using an isolate, GifN_001 strain, demonstrated that this strain has oncogenicity in the central nervous system in chickens. GifN strains are the first neuropathogenic ALVs isolated from chickens affected with osteoporosis in chickens.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2018 2016 2015

All Presentation (4 results)

  • [Presentation] 粘液肉腫由来トリ白血病ウイルスの神経系に対する病原性解析2018

    • Author(s)
      近藤佑衣,西浦颯,可知正行,佐々木淳,御領政信,落合謙爾
    • Organizer
      第5回日本獣医病理学専門家協会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 鶏の骨化石症に併発したグリオーマの病理学的解析2016

    • Author(s)
      窪田郁子,落合謙爾,川島慎吾,佐々木淳,御領政信
    • Organizer
      日本獣医病理学専門家協会学術集会
    • Place of Presentation
      三鷹市公会堂(東京都三鷹市)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 最近発見された鶏のグリオーマの病理学的特徴2016

    • Author(s)
      川島慎吾,落合謙爾,窪田郁子,佐々木淳,御領政信
    • Organizer
      平成27年度岩手県鶏病研究会鶏病技術研修会
    • Place of Presentation
      岩手県水産会館(岩手県盛岡市)
    • Year and Date
      2016-03-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ブロイラーで新たに見つかった神経病原性トリ白血病ウイルスの病理と疫学2015

    • Author(s)
      窪田郁子,落合謙爾,畑井仁,阿左美有右,佐々木淳,御領政信
    • Organizer
      平成27年度東北地区獣医師大会・獣医学術東北地区学会
    • Place of Presentation
      ホテル東日本(岩手県盛岡市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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