Species-dependent neural function organized by non-coding RNAs
| Project/Area Number |
15H04603
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 種特異的 / 転写因子 / ノンコーディングRNA / DNA脱メチル化 / 神経幹細胞 / エピジェネティクス / 進化 / エピゲノム / ノンコーディング / 霊長類 / 生物多様性 |
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| Outline of Final Research Achievements |
Vast majority of the fundamental research projects on the mammalian brain utilize the mouse systems. However, morphological and functional differences between primates and rodents evidently exist, and therefore, the molecules that underlie the generation of the differences need be identified. In this study, focusing on the promoter-associated non-coding RNAs (pancRNAs), the comprehensive databases have been made for 5 different mammalian species. Now functional pancRNAs are being screened, that potentially differentiate the neural stem cell behaviors depending on species.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.2017
Author(s)
Sanosaka T, Imamura T, Hamazaki N, Chai M, Igarashi K, Ideta-Otsuka M, Miura F, Ito T, Fujii N, Ikeo K, Nakashima K
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Journal Title
Cell Rep
Volume: 20
Issue: 12
Pages: 2992-3003
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Reconstitution in vitro of the entire cycle of the mouse female germ line.2016
Author(s)
Hikabe O, Hamazaki N, Nagamatsu G, Obata Y, Hirao Y, Hamada N, Shimamoto S, Imamura T, Nakashima K, Saitou M, Hayashi K
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Journal Title
Nature
Volume: 539
Issue: 7628
Pages: 299-303
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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