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Generalization for evaluation of the neuropeptide network in the regulatory mechanisms of insect feeding

Research Project

Project/Area Number 15H04609
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Insect science
Research InstitutionThe University of Tokyo

Principal Investigator

Nagata Shinji  東京大学, 大学院新領域創成科学研究科, 准教授 (40345179)

Co-Investigator(Renkei-kenkyūsha) KURAISHI Takayuki  金沢大学, 大学院医薬保健学総合研究科, 准教授 (90613167)
SUZUKI Masataka  東京大学, 大学院新領域創成科学研究科, 准教授 (30360572)
KUTSUNA Natsumaro  東京大学, 大学院新領域創成科学研究科, 特任准教授 (70578559)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords昆虫 / 摂食行動 / ホルモン / ネットワーク / ペプチドホルモン / 昆虫生理生化学 / 行動学 / 内分泌学
Outline of Final Research Achievements

Animal feeding behavior is controlled by bioactive factors and hormones from brain and central nervous system. So far, scientists, however, have not answered the question "What to eat?" We are addressing such instinctive behavioral mechanisms using an insect, the two-spotted cricket. Infrastructure for analyses of nutrient preference behavior has been generated as well as techniques of molecular biology. We now know the fact that hormones can regulate the systems of feeding behavior and that metabolisms in the peripheral tissues such as adipose tissue can modify them. Further, we depicted the network constituted by hormones, implying that we are now ready to obtain the evaluation system for the network constituted by hormones and metabolisms. Based on the current research, we hope that the behavioral prediction counted by the evaluation system of hormone network is upcoming in the near future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (37 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (29 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Adipokinetic hormone signaling determines dietary fatty acid preference through maintenance of hemolymph fatty acid composition in the cricket Gryllus bimaculatus2018

    • Author(s)
      Fukumura Keisuke、Konuma Takahiro、Tsukamoto Yusuke、Nagata Shinji
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 4737-4737

    • DOI

      10.1038/s41598-018-22987-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of adipokinetic hormone and its related peptide on maintaining hemolymph carbohydrate and lipid levels in the two-spotted cricket, Gryllus bimaculatus2018

    • Author(s)
      Zhou Yi Jun、Fukumura Keisuke、Nagata Shinji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 2 Pages: 274-284

    • DOI

      10.1080/09168451.2017.1422106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Behavioral tracing demonstrates dietary nutrient discrimination in two-spotted crickets Gryllus bimaculatus2017

    • Author(s)
      Fukumura Keisuke、Nagata Shinji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 10 Pages: 1990-1993

    • DOI

      10.1080/09168451.2017.1343119

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Calcitonin-like peptide hormone (CT/DH) in the frontal ganglia as a feeding regulatory peptide of the silkworm, Bombyx mori.2017

    • Author(s)
      Nagata S, Nagasawa H
    • Journal Title

      Peptides

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Newly identified allatostatin Bs and their receptor in the two-spotted cricket, Gryllus bimaculatus2016

    • Author(s)
      塚本悠介、永田晋治
    • Journal Title

      Peptiedes

      Volume: 印刷中 Pages: 25-31

    • DOI

      10.1016/j.peptides.2016.03.015

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Takahiro Konuma, Yusuke Tsukamoto, Hiromichi Nagasawa, Shinji Nagata*: Imbalanced hemolymph lipid levels affect feeding motivation in the two-spotted cricket, Gryllus bimaculatus2016

    • Author(s)
      Takahiro Konuma, Yusuke Tsukamoto, Hiromichi Nagasawa, Shinji Nagata
    • Journal Title

      PLoS One

      Volume: 11 Issue: 5 Pages: e0154841-e0154841

    • DOI

      10.1371/journal.pone.0154841

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tachykinin-related peptides share a G Protein-coupled receptor with ion transport peptide-like in the silkworm, Bombyx mori2016

    • Author(s)
      Okatani-Nagai C, Nagasawa H, Nagata S
    • Journal Title

      Plos One

      Volume: 11 Issue: 6 Pages: e0156501-e0156501

    • DOI

      10.1371/journal.pone.0156501

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] フタホシコオロギにおけるNeuropeptide Fによる摂食行動の制御機構の解明2018

    • Author(s)
      清家瞳、福村圭介、永田晋治
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of adipokinetic hormone and its related peptide on maintaining hemolymph carbohydrate and lipid levels in the two-spotted cricket Gryllus bimaculatus2018

    • Author(s)
      Zhou Y Jun、福村圭介、永田晋治
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カイコBombyx moriにおけるDHCR24ホモログタンパク質の酵素活性測定2018

    • Author(s)
      藤盛春奈、永田晋治
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 昆虫類のステロール生合成の欠損とステロール要求性2018

    • Author(s)
      永田晋治
    • Organizer
      日本農芸化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フタホシコオロギ(Gryllus bimaculatus)における菌感染が摂食行動に与える影響2018

    • Author(s)
      久保健一、福村圭介、伊藤尚子、永田晋治
    • Organizer
      蚕糸昆虫学術利用講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおけるAKHシグナリングが栄養分選好性行動へ与える影響2018

    • Author(s)
      福村圭介、永田晋治
    • Organizer
      蚕糸昆虫学術利用講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カイコ (Bombyx mori )幼虫における摂食行動制御因子アラトトロピン及びGSRYamideの機能解析2017

    • Author(s)
      松本 澄洋、永田 晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都、京都女子大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおける卵巣摘出による摂食行動変化と脂肪体の転写変動解析2017

    • Author(s)
      塚本悠介、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都、京都女子大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおける異なる脂肪酸間での経時的な選好性行動解析2017

    • Author(s)
      福村圭介、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都、京都女子大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] フタホシコオロギの捕食行動における異種個体の認識2017

    • Author(s)
      吉國大稀、森山俊、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都、京都女子大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of Crustacean Cardioactive peptide (CCAP) on feeding behavior in the two-spotted crickets, Gryllus bimaclatus2017

    • Author(s)
      Yijun ZHOU, Shinji NAGATA
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都、京都女子大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusを用いた内分泌ネットワークによる脂肪組織での代謝制御および摂食行動へ与える影響の解析2017

    • Author(s)
      福村圭介、永田晋治
    • Organizer
      日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおける交尾と卵巣摘出によるタンパク質選好性と脂肪体の代謝変化の関連性2017

    • Author(s)
      塚本悠介、永田晋治
    • Organizer
      日本分子生物学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 昆虫の代謝系と内分泌系が制御する行動修飾2017

    • Author(s)
      永田晋治
    • Organizer
      日本比較内分泌学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フタホシコオロギにおけるペプチドホルモン類の同定と他の昆虫種との進化的な比較考察2016

    • Author(s)
      永田晋治、塚本悠介、福村圭介、Zhou Yi Jun、森山 俊、藤盛春奈、土本真帆、吉國大稀
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      北里大学相模原キャンパス
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusを用いたAKHシグナリングに調節される不飽和脂肪酸への選好性摂食行動解析2016

    • Author(s)
      福村圭介、永田晋治
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜、国際会議場
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Endocrinal control in nutrition-dependent feeding behavior in insects2016

    • Author(s)
      永田晋治
    • Organizer
      動物学会国際シンポジウム
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Feeding motivation modulated by lipid quality and quantity via adipokinetic hormone in insects2016

    • Author(s)
      Shinji Nagata
    • Organizer
      Asia Oceania Symposium of Comparative Endocrinology 2016 (AOSCE)
    • Place of Presentation
      高麗大学、ソウル韓国
    • Year and Date
      2016-06-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フタホシコオロギGryllus bimaculatus とカイコBombyx mori におけるDHCR24様タンパク質の生化学的解析2016

    • Author(s)
      藤盛 春奈、永田 晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      札幌コンベンションセンター 北海道札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおけるAKHシグナリングによる摂食行動と脂肪酸組成の調節機構2016

    • Author(s)
      福村 圭介、小沼 貴裕、永田 晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      札幌コンベンションセンター 北海道札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおけるアラトスタチン Bおよびその受容体の同定2016

    • Author(s)
      塚本 悠介、永田 晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      札幌コンベンションセンター 北海道札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおける神経ペプチドCCHamideおよびその受容体の同定2016

    • Author(s)
      土本 真帆、永田 晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      札幌コンベンションセンター 北海道札幌市
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 昆虫の摂食行動を支配する内分泌ネットワーク2016

    • Author(s)
      永田 晋治
    • Organizer
      日本農薬学会
    • Place of Presentation
      島根大学松江キャンパス 島根県松江市
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Differential expression pattern of short neuropeptide F receptors in the silkworm, Bombyx mori2016

    • Author(s)
      永田晋治
    • Organizer
      Invertebrate neuropeptide conference 2016
    • Place of Presentation
      ブラジル国 ミナス・ジェライス州 オウロプレット
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] フタホシコオロギのリポホリンIIIによる摂食行動の変化2015

    • Author(s)
      永田晋治、小沼貴裕
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際展示場 兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] フタホシコオロギのインスリン様ペプチドにおけるスプライシングバリアントの発現調節2015

    • Author(s)
      塚本悠介、張敏珠、藤盛春奈、永田晋治
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際展示場 兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 「DHCR24のカイコBombyx moriにおける2種類の相同遺伝子の発現解析2015

    • Author(s)
      藤盛春奈、永田晋治
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際展示場 兵庫県神戸市
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hormonal network in the regulation of nutrition dependent feeding behavior2015

    • Author(s)
      永田晋治
    • Organizer
      日本動物学会
    • Place of Presentation
      朱鷺メッセ 新潟県新潟市
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 昆虫の摂食行動を調節する生理活性物質とそのホルモンネットワークによる制御2015

    • Author(s)
      永田晋治
    • Organizer
      GPCR研究会
    • Place of Presentation
      日本未来科学館 東京都港区
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research2015

    • Author(s)
      永田晋治
    • Total Pages
      675
    • Publisher
      Elsevier
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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