• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy

Research Project

Project/Area Number 15H04635
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionTokyo Institute of Technology

Principal Investigator

NISHIYAMA Nobuhiro  東京工業大学, 科学技術創成研究院, 教授 (10372385)

Co-Investigator(Kenkyū-buntansha) 野本 貴大  東京工業大学, 科学技術創成研究院, 助教 (00734732)
武元 宏泰  東京工業大学, 科学技術創成研究院, 助教 (10709249)
Co-Investigator(Renkei-kenkyūsha) AOKI Ichio  量子科学技術研究開発機構, 放射線医学研究開発部門, チームリーダー (10319519)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsがん細胞 / がん代謝 / ターティング / 合成高分子 / アミノ酸トランスポーター / ターゲティング / 治療抵抗性がん / イメージング / 高分子ミセル / 光線力学治療 / 治療抵抗生がん
Outline of Final Research Achievements

In this study, we have developed a novel ligand molecule based on the common metabolic pathway to cancer cells (aberrant glutamine metabolism), using synthetic polymers. In vitro experiments confirmed that the ligand molecules, poly(amino acids) having glutamine moieties at the side chain, selectively interact with cancer cells through the multivalent binging to the glutamine transporter ASCT2 overexpressed in cancer cells. Confocal microscopic observation revealed that the ligand molecules are internalized by cancer cells, reaching lysosomal compartments. In vivo experiments demonstrated that the ligand molecules directly injected to the tumor showed longer retention compared with control ligands. These results suggest the utility of the ligand molecules as a versatile targeting technique specific to cancer cells. The novel ligand molecules are expected to be applied to cancer diagnosis and therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (67 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (22 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 22 results,  Open Access: 10 results,  Acknowledgement Compliant: 3 results) Presentation (40 results) (of which Int'l Joint Research: 14 results,  Invited: 16 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] 四川大学(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] アラバマ大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] An Ethylenediamine‐based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials2018

    • Author(s)
      Abdul-Hackam Ranneh, Hiroyasu Takemoto, Shunya Sakuma, Aziz Awaad, Takahiro Nomoto, Yuki Mochida, Makoto Matsui, Keishiro Tomoda, Mitsuru Naito, Nobuhiro Nishiyama
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 18 Pages: 5057-5061

    • DOI

      10.1002/anie.201801641

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain2017

    • Author(s)
      Anraku Y.、Kuwahara H.、Fukusato Y.、Mizoguchi A.、Ishii T.、Nitta K.、Matsumoto Y.、Toh K.、Miyata K.、Uchida S.、Nishina K.、Osada K.、Itaka K.、Nishiyama N.、Mizusawa H.、Yamasoba T.、Yokota T.、Kataoka K.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 2001-2009

    • DOI

      10.1038/s41467-017-00952-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sonodynamic therapy based on combined use of low dose administration of epirubicin-incorporating drug delivery system and focused ultrasound2017

    • Author(s)
      M. Maeda, Y. Muragaki, J. Okamoto, S. Yoshizawa, N. Abe, H. Nakamoto, H. Ishii, K. Kawabata, S. Umemura, N. Nishiyama, K. Kataoka, H. Iseki
    • Journal Title

      Ultrasound Med. Biol.

      Volume: 43 Issue: 10 Pages: 2295-2301

    • DOI

      10.1016/j.ultrasmedbio.2017.06.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells2017

    • Author(s)
      Miyano Kazuki、Cabral Horacio、Miura Yutaka、Matsumoto Yu、Mochida Yuki、Kinoh Hiroaki、Iwata Caname、Nagano Osamu、Saya Hideyuki、Nishiyama Nobuhiro、Kataoka Kazunori、Yamasoba Tatsuya
    • Journal Title

      J Control Release

      Volume: 261 Pages: 275-286

    • DOI

      10.1016/j.jconrel.2017.06.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors2017

    • Author(s)
      S. Quader, X. Liu, Y. Chen, P. Mi, T. Chida, T. Ishii, Y. Miura, N. Nishiyama, H. Cabral, K. Kataoka
    • Journal Title

      J. Control. Release

      Volume: 258 Pages: 56-66

    • DOI

      10.1016/j.jconrel.2017.04.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer2017

    • Author(s)
      H. Taniguchi, D. Hoshino, C. Moriya, H. Zembutsu, N. Nishiyama, H. Yamamoto, K. Kataoka, K. Imai
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 29 Pages: 46856-46874

    • DOI

      10.18632/oncotarget.16776

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism2017

    • Author(s)
      Yamada Naoki、Honda Yuto、Takemoto Hiroyasu、Nomoto Takahiro、Matsui Makoto、Tomoda Keishiro、Konno Masamitsu、Ishii Hideshi、Mori Masaki、Nishiyama Nobuhiro
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 6077-6077

    • DOI

      10.1038/s41598-017-06438-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors.2017

    • Author(s)
      P. Mi, H. Yanagie, N. Dewi, H.-C. Yen, X. Liu, M. Suzuki, Y. Sakurai, K. Ono, H. Takahashi, H. Cabral, K. Kataoka,
    • Journal Title

      J. Control. Release

      Volume: 254 Pages: 1-9

    • DOI

      10.1016/j.jconrel.2017.03.036

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017

    • Author(s)
      M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka
    • Journal Title

      J. Biomater. Sci. Polym.

      Volume: 28 Issue: 10-12 Pages: 1109-1123

    • DOI

      10.1080/09205063.2017.1301775

    • Description
      【掲載確定】 in press
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice2017

    • Author(s)
      C. Moriya, H. Taniguchi, K. Miyata, N. Nishiyama, K. Kataoka, K. Imai
    • Journal Title

      Carcinogenesis

      Volume: 38 Issue: 6 Pages: 638-648

    • DOI

      10.1093/carcin/bgx040

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional polymer-based siRNA delivery carrier that recognizes site-specific biosignals2017

    • Author(s)
      Hiroyasu Takemoto, Nobuhiro Nishiyama
    • Journal Title

      Journal of Controlled Release

      Volume: 267 Pages: 90-99

    • DOI

      10.1016/j.jconrel.2017.09.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of the 2-nitrobenzenesulfonamide group as a chemical linker for enhanced extracellular stability and cytosolic cleavage in siRNA-conjugated polymer systems2017

    • Author(s)
      C. H. Huang, H. Takemoto, T. Nomoto, K. Tomoda, M. Matsui, N. Nishiyama
    • Journal Title

      ChemMedChem

      Volume: 12 Issue: 1 Pages: 19-22

    • DOI

      10.1002/cmdc.201600488

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer.2016

    • Author(s)
      Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J
    • Journal Title

      Translational Oncology.

      Volume: 9 Issue: 3 Pages: 203-210

    • DOI

      10.1016/j.tranon.2016.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Artificial Control of Gene Silencing Activity Based on siRNA Conjugation with Polymeric Molecule Having Coil Globule Transition Behavior2016

    • Author(s)
      Noor Faizah Che Harun, Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, and Nobuhiro Nishiyama
    • Journal Title

      Bioconjugate Chemistry

      Volume: 27 Issue: 9 Pages: 1961-1964

    • DOI

      10.1021/acs.bioconjchem.6b00322

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of PEGylated poly(amino acid) pentablock copolymers and their self-assembly.2016

    • Author(s)
      Iijima, M., Ulkoski, D., Sakuma, S., Matsukuma, D., Nishiyama, N., Otsuka, H. and Scholz, C.
    • Journal Title

      Polym. Int.

      Volume: 65 Issue: 10 Pages: 1132-1141

    • DOI

      10.1002/pi.5159

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy.2016

    • Author(s)
      P. Mi, D. Kokuryo, H. Cabral, H. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, K. Kataoka,
    • Journal Title

      Nat. Nanotechnol.

      Volume: 11 Issue: 8 Pages: 724-730

    • DOI

      10.1038/nnano.2016.72

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nanomedicines eradicating cancer stem-like cells in vivo by pH-triggered intracellular cooperative action of loaded drugs.2016

    • Author(s)
      H. Kinoh, Y. Miura, T. Chida, X. Liu, K. Mizuno, S. Fukushima, Y. Morodomi, N. Nishiyama, H. Cabral, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 10 Issue: 6 Pages: 5643-5655

    • DOI

      10.1021/acsnano.6b00900

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG1322016

    • Author(s)
      Matsumoto Y, Miyamoto Y, Cabral H, Matsumoto Y, Nagasaka K, Nakagawa S, Yano T, Maeda D, Oda K, Kawana K, Nishiyama N, Kataoka K, Fujii T
    • Journal Title

      Cancer Sci

      Volume: 107 Issue: 6 Pages: 773

    • DOI

      10.1111/cas.12926

    • NAID

      120007089072

    • URL

      https://pure.teikyo.jp/en/publications/ba568e7f-01a0-47eb-a707-2c1b9629acb6

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of polymeric micelles for targeting intractable cancers2016

    • Author(s)
      N. Nishiyama, Y. Matsumura, K. Kataoka
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 7 Pages: 867-874

    • DOI

      10.1111/cas.12960

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate-based organic-inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy2016

    • Author(s)
      T. Nomoto, S. Fukushima, M. Kumagai, K. Miyazaki, A. Inoue, P. Mi, Y. Maeda, K. Toh, Y. Matsumoto, Y. Morimoto, A. Kishimura, N. Nishiyama, K. Kataoka
    • Journal Title

      Biomater. Sci.

      Volume: 印刷中 Issue: 5 Pages: 826-838

    • DOI

      10.1039/c6bm00011h

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular Delivery of Charge-Converted Monoclonal Antibodies by Combinatorial Design of Block/Homo Polyion Complex Micelles2016

    • Author(s)
      Ahram Kim, Yutaka Miura, Takehiko Ishii, Omer F. Mutaf, Nobuhiro Nishiyama, Horacio Cabral, Kazunori Kataoka
    • Journal Title

      Biomacromolecules

      Volume: 17 Issue: 2 Pages: 446-453

    • DOI

      10.1021/acs.biomac.5b01335

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis2016

    • Author(s)
      Jun Makino, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Ming Wang, Hiroaki Kinoh, Yuki Mochida, Nobuhiro Nishiyama, Kazunori Kataoka
    • Journal Title

      Journal of Controlled Release

      Volume: 220 PartB Pages: 783-791

    • DOI

      10.1016/j.jconrel.2015.10.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Development of Smart Nanodiagnostics for Targeted Cancer Therapy2018

    • Author(s)
      西山伸宏
    • Organizer
      第2回MRIアライアンス国際シンポジウム2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate2017

    • Author(s)
      Hiroyasu Takemoto, Huang Chih-Hao, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel design of glutamine-derived polymer with a high affinity to cancer cells based on aberrant glutamine metabolism2017

    • Author(s)
      Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
    • Organizer
      253rd American Chemical Society National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん特異的代謝に着想した外殻にグルタミンを有する高分子ミセルの開発2017

    • Author(s)
      真貝太規、山田直生、武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
    • Organizer
      第66回高分子年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖阻害剤を腫瘍組織に送達するための高分子ミセルの開発2017

    • Author(s)
      劉暁夢、武元宏泰・野本貴大・松井誠・友田敬士郎・西山伸宏
    • Organizer
      第66回高分子年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-2017

    • Author(s)
      左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
    • Organizer
      第66回高分子年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2-Nitrobenzenesulfonamide group as a redox-sensitive linker for a construction of polymer-siRNA conjugate system2017

    • Author(s)
      Hiroyasu Takemoto, Chih Hao Huang, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
    • Organizer
      第66回高分子年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Design of synthetic polymer toward achieving a selective high affinity to tumor cells by interacting with dense glutaminolysis-related transporters2017

    • Author(s)
      Naoki Yamada, Yuto Honda, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyamam
    • Organizer
      第66回高分子年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2-Nitrobenzenesulfonamide group that responds to intracellular redox potential with enhanced photostability for a construction of polymer-siRNA conjugate system2017

    • Author(s)
      Hiroyasu Takemoto, Huang Chih-Hao, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
    • Organizer
      The 34th International Conference of Photopolymer Science and Technology (ICPST-34)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ナノ材料を基盤とするスマート診断・治療システムの開発2017

    • Author(s)
      西山伸宏
    • Organizer
      ナレッジキャピタル超学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲムシタビンのポリアミノ酸への可逆的担持に基づく消化器毒性低減及び制がん効果向上2017

    • Author(s)
      武元宏泰, 稲葉高徳, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 革新的オリゴ核酸送達システムの実現に向けた材料設計2017

    • Author(s)
      西山伸宏
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Design of functional polymers for cancer diagnosis and therapy2017

    • Author(s)
      西山伸宏
    • Organizer
      化学系学協会東北大会 高分子コロキウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] がん代謝に着想した表層にグルタミンを有する高分子ミセル型薬物送達システムの開発2017

    • Author(s)
      真貝太規、山田直生, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腫瘍指向性ステルス高分子の開発とDDS への応用-ベタイン構造内アニオン性基の影響-2017

    • Author(s)
      左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 光増感剤結合型高分子における多岐環状RGDペプチドの腫瘍集積性と腫瘍内分布への効果の検討2017

    • Author(s)
      Dou Xuebo、野本貴大、武元宏泰、松井 誠、友田敬士郎、西山伸宏
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 機能性高分子を利用した核酸医薬送達システムの開発2017

    • Author(s)
      西山伸宏
    • Organizer
      創薬薬理フォーラム 第25回シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 糖骨格を有する制がん剤のポリアミノ酸への可逆的担持と薬効向上及び消化器毒性低減2017

    • Author(s)
      武元宏泰、稲葉高徳、野本貴大、松井誠、友田敬士郎、西山伸宏
    • Organizer
      第66回高分子討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Design of functional polymers for smart nanomedicine2017

    • Author(s)
      Nobuhiro Nishiyama
    • Organizer
      5th International Symposium on Smart Biomaterials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] スマート機能型DDSのための機能性高分子設計2017

    • Author(s)
      西山伸宏
    • Organizer
      高分子学会関東支部 バイオと科学の融合領域
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん選択的に相互作用するグルタミン担持高分子の創製と機能評価,2017

    • Author(s)
      山田直生, 本田雄士,武元宏泰,野本貴大,松井 誠,友田敬士郎,西山伸宏
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 2-Nitrobenzenesulfonamide group that allows highly selective cleavage in intracellular redox system and the application for a construction of siRNA-polymer conjugate2017

    • Author(s)
      Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
    • Organizer
      14th US-JAPAN Symposium on Drug Delivery Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Glutamine-functionalized polymer for tumor-selective high affinity by sensing dense glutamine transporters associated with aberrant metabolism2017

    • Author(s)
      Naoki Yamada, Naoki Yamada, Yuto Honda, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
    • Organizer
      14th US-JAPAN Symposium on Drug Delivery Systems
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of smart polymers and nanodevices for innovative medicine”, International Symposium on Materials for Chemistry and Engineering (IMCE2017)2017

    • Author(s)
      N. Nishiyama
    • Organizer
      Symposium on Materials for Chemistry and Engineering (IMCE2017)
    • Place of Presentation
      Chikushi Hall (C-CUBE), Kyushu University, Fukuoka
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of polymer-based nanodevices for innovative medicine2017

    • Author(s)
      N. Nishiyama
    • Organizer
      Snowbird Symposium for Dr. Kopecek
    • Place of Presentation
      Snowbird, Utah, U.S.A.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of smart nanomachines for cancer imaging and minimally invasive treatment2017

    • Author(s)
      N. Nishiyama
    • Organizer
      11th Annual Symposium on Nanobiotechnology 2017
    • Place of Presentation
      Kawasaki City Industrial Promotion Hall, Kawasaki City
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高分子ミセル型ナノマシンが拓く未来医療2016

    • Author(s)
      西山伸宏
    • Organizer
      第63回日本実験動物学会総会
    • Place of Presentation
      ミューザ川崎シンフォニーホール, 川崎市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高分子ミセル型ナノ医薬品の開発-アカデミアからの取り組み-2016

    • Author(s)
      西山伸宏
    • Organizer
      第32回日本DDS学会学術大会
    • Place of Presentation
      グランシップ, 静岡市
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高分子ナノテクノロジーを基盤とする革新的がん診断・治療システムの創出2016

    • Author(s)
      西山伸宏
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      湯沢東映ホテル, 新潟県南魚沼郡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とした革新的ナノ診断・治療システムの開発2016

    • Author(s)
      西山伸宏
    • Organizer
      日本薬物動態学会 第31回年会
    • Place of Presentation
      キッセイ文化ホール, 松本市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 精密合成高分子材料を基盤するがん診断・治療ナノマシンの創製2016

    • Author(s)
      西山伸宏
    • Organizer
      科研費新学術領域「分子ロボティクス」公開シンポジウム
    • Place of Presentation
      タワーホール船堀, 東京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ナノテクノロジーが拓く未来医療 -体内病院の実現を目指して-2016

    • Author(s)
      西山伸宏
    • Organizer
      第11回 四大学連合文化講演会
    • Place of Presentation
      一橋講堂 学術総合センター, 東京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of supramolecular nanodevices for cancer diagnostics and therapy2016

    • Author(s)
      N. Nishiyam
    • Organizer
      he Korean Academy of Science and Technology (KAST) Symposium for Young Scientists in Drug Delivery: Redirecting the Research Field
    • Place of Presentation
      KIST, Korea
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とするがん診断・治療システムの創製2016

    • Author(s)
      西山伸宏
    • Organizer
      第2回神奈川県ヘルスケア・ニューフロティア講座 次世代医療に向けた医理工学融合研究とその産業応用
    • Place of Presentation
      東京工業大学大岡山キャンパス, 東京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of supramolecular nanodevices for cancer diagnosis and therapy2015

    • Author(s)
      N. Nishiyama
    • Organizer
      World Engineering Conference and Convention 2015 (WECC2015)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高分子ナノテクノロジーを基盤とした革新的ナノメディシンの創製2015

    • Author(s)
      西山伸宏
    • Organizer
      第10回超分子研究会講座
    • Place of Presentation
      上智大学, 東京
    • Year and Date
      2015-10-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高分子の精密設計に基づく革新的がん診断・治療システムの創製2015

    • Author(s)
      西山伸宏
    • Organizer
      第24回DDSカンファランス
    • Place of Presentation
      静岡市東部勤労者福祉センター, 静岡
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ナノバイオテクノロジーが拓く新生代ドラッグデリバリーシステム2015

    • Author(s)
      西山伸宏
    • Organizer
      第25回日本光線力学学会
    • Place of Presentation
      京王プラザホテル, 東京
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Development of supramolecular nanodevices for cancer diagnosis and therapy2015

    • Author(s)
      N. Nishiyama
    • Organizer
      Recent Advances in Drug Delivery Systems 17th International Symposium
    • Place of Presentation
      Salt Lake City Marriott City Center, Salt Lake City, U.S.A.
    • Year and Date
      2015-06-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of supramolecular nanodevices for cancer diagnosis and therapy2015

    • Author(s)
      N. Nishiyama
    • Organizer
      The 5th Asian Biomaterials Congress (2015 ABMC5)
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 東京工業大学 化学生命科学研究所 西山研究室

    • URL

      http://www.bmw.res.titech.ac.jp

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report
  • [Patent(Industrial Property Rights)] グルタミントランスポーターと多価結合することができるリガンド, 及び当該リガンドを含む組成物2017

    • Inventor(s)
      西山伸宏、武元宏泰、野本貴大、他7名
    • Industrial Property Rights Holder
      東京工業大学, 大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] グルタミントランスポーターと多価結合することができるリガンド, 及び当該リガンドを含む組成物2016

    • Inventor(s)
      西山伸宏, 武元宏泰, 野本貴大, 友田敬士郎, 松井誠 他
    • Industrial Property Rights Holder
      東京工業大学, 大阪大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-161774
    • Filing Date
      2016-08-22
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-10-07  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi