| Project/Area Number |
15H04641
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Aomori University (2016-2017)
Gunma University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 幸市 群馬大学, 生体調節研究所, 准教授 (00302498)
|
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| Research Collaborator |
MOGI Chihiro
AOKI Haruka
HISADA Takeshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | プロトン / TDAG8 / OGR1 / GPR4 / ミクログリア / 骨代謝 / 内皮細胞 / 樹状細胞 / シグナル伝達 / 神経化学 / 生理学 / T細胞 |
|---|
| Outline of Final Research Achievements |
It is well known that acidification takes place in the ischemia and inflammatory region. However, how extracellular acidic pH regulates physiological and pathophysiological actions remains uncharacterized yet. In the present study, we investigated the roles of OGR1 family GPCRs, including OGR1, TDAG8, and GPR4, which have been recently identified as extracellular proton-sensing receptors, in bone remodeling, brain ischemia, tumorigenesis, and asthma. The results showed that these receptors play important roles in the physiological cellular functions and the development of ischemic and inflammatory disorders. We further characterized a novel GPR4 antagonist and found that it was effective in the myocardial infarction model.
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