| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
We found that nuclear RNA degradation pathway is dysregulated in response to Salmonella infection, causing the upregulation of nuclear long noncoding RNAs that are unstable in human nucleus of naïve cells. The nuclear long noncoding RNAs induced upon Salmonella infection are involved in the regulation of immune-related genes such as interferons. In addition, we showed that MTR4, an important component of nuclear RNA degradation pathways, are diminished after Salmonella infection. Our study clearly show the importance of nuclear RNA degradation pathway in immune response.
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