Analysis of sensing and responding mechanisms for osmotic stress in mammalian cells
| Project/Area Number |
15H04643
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
Naguro Isao 東京大学, 大学院薬学系研究科(薬学部), 准教授 (80401222)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
|---|
| Keywords | 浸透圧ストレス / ASK3 / NFAT5 / ゲノムワイドsiRNAスクリーニング / シグナル伝達 / siRNAスクリーニング |
|---|
| Outline of Final Research Achievements |
Recently, molecules that function in cellular osmotic stress response have been reported to be involved in the regulation of blood pressure, inflammation and immune system. However, the precise molecular mechanism for sensing and transducing osmotic stress in mammalian cells still remains to be elucidated. In this project, we focused on ASK3 and NFAT5, two molecules responding to osmotic stress. With original methodologies, such as genome-wide siRNA screens and specific cross-linking technology, we have elucidated new molecular mechanisms regulating osmotic stress response in mammalian cells.
|
Report
(4 results)
Research Products
(47 results)
-
-
-
-
[Journal Article] TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1 negative regulator PRMT1.2017
Author(s)
Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H., Matsuzawa, A.
-
Journal Title
Cell Rep.
Volume: 21
Issue: 9
Pages: 2447-2457
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.2017
Author(s)
Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., Ichijo, H.
-
Journal Title
Cell Death and Differentiation
Volume: 24
Issue: 12
Pages: 2066-2076
DOI
Related Report
Peer Reviewed
-
[Journal Article] Involvement of apoptosis signal-regulating kinase-1 in house dust miteinduced allergic asthma in mice2017
Author(s)
Maruoka, S., Gon, Y., Mizumura, K., Okamoto, S., Tsuya, K., Shikano, S., Soda, K., Naguro, I., Ichijo, H. and Hashimoto, S.
-
Journal Title
Allergology International
Volume: 66
Issue: Supplement.1
Pages: S50-S52
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
