| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In this study, we identified omega-3 eicosapentaenoic acid (EPA)-derived bioactive metabolite, namely 17,18-EpETE, that possess anti-inflammatory and/or anti-allergic actions in vivo. Moreover, we identified cytochrome P450 (CYP) enzymes that play rate-limiting roles in controlling active conversion of EPA into 17,18-EpETE. These findings will elucidate the physiological importance of this metabolic pathway of omega-3 fatty acids in controlling inflammation and related diseases. Also we demonstrated the importance of fatty acid balance and their metabolic interactions in many disease models by using the advanced LC-MS/MS-based lipidomics system.
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