| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We could demonstrate that nitric oxide (NO) regulates epigenetic enzymes. A cysteine residue was a target of NO and its covalent modification contributed to the inhibition of enzymatic activity in cells. From these findings, we speculated that NO may be involved in the up-regulation of several genes via this mechanism. Next, we conducted DNA micro array for isolating genes that is sensitive to NO. We could isolate several genes regulated by NO. Thus, we could propose a novel system of gene expression via nitrosative stress in this study.
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