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Creation of regeneration accelerating molecules using target protein oriented natural products isolation (TPO-NAPI)

Research Project

Project/Area Number 15H04650
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Natural medicines
Research InstitutionChiba University

Principal Investigator

Arai Midori  千葉大学, 大学院薬学研究院, 准教授 (40373261)

Co-Investigator(Renkei-kenkyūsha) ISHIBASHI Masami  千葉大学, 大学院薬学研究院, 教授 (90212927)
KOUDA Masao  筑波大学, 医学医療系サイバニクス研究センター, 准教授 (50361449)
TAMURA Yutaka  千葉大学, 大学院医学研究院, 准教授 (50263174)
ARAI Takayoshi  千葉大学, 大学院理学研究院, 教授 (80272483)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords幹細胞 / 天然物 / タンパク質ビーズ / ヘッジホッグ / ノッチ / Hes1 / 神経分化 / タンパク質 / 再生 / ケミカルバイオロジー
Outline of Final Research Achievements

Search for stem cells modulators has been done using screening system of natural resources extracts library. Bioactive natural products which bind on Hes1 (bHLH factor), GLI1 (Hedgehog signaling transcriptional factor) and NICD (Notch signaling transcriptional factor ) were efficiently found by using “target protein oriented natural products isolation (TPO-NAPI)”. In addition, bioactivity fractionation using cell-based reporter assay gave Notch signal inhibitors such as uscharin.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (110 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (29 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 29 results,  Open Access: 4 results,  Acknowledgement Compliant: 19 results) Presentation (76 results) (of which Int'l Joint Research: 17 results,  Invited: 13 results) Remarks (1 results)

  • [Int'l Joint Research] khulna University/University of Dhaka(バングラデシュ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Khon Kaen University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Khulna University/University of Dhaka(バングラデシュ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Khon Kaen University(タイ)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The Notch inhibitor cowanin accelerates nicastrin degradation2018

    • Author(s)
      Arai, M. A.*; Akamine, R.; Tsuchiya, A.; Yoneyama, T.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*
    • Journal Title

      Sci. Rep.

      Volume: 8 Issue: 1 Pages: 5376-5376

    • DOI

      10.1038/s41598-018-23698-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis of lignan glycosides with antioxidant activity2018

    • Author(s)
      Sampei, M.; Arai, M. A.*; Ishibashi, M.*
    • Journal Title

      J. Nat. Med.

      Volume: in press Issue: 3 Pages: 651-654

    • DOI

      10.1007/s11418-018-1198-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New flavanol dimers from the bark of Celtis tetranda and their TRAIL resistance-overcoming activity2018

    • Author(s)
      Seephonkai, P.; Ishikawa, R.; Arai, M. A.; Kowithayakorn, T.; Koyano, T.; Ishibashi, M.
    • Journal Title

      Nat. Prod. Commun.

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of animal cells2018

    • Author(s)
      Hara, Y.; Arai, M. A.; Sakai, K.; Ishikawa, N.; Gonoi, T.; Yaguchi, T.; Ishibashi, M.
    • Journal Title

      J. Nat. Med.

      Volume: 72 Issue: 1 Pages: 280-289

    • DOI

      10.1007/s11418-017-1161-y

    • NAID

      40021456166

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of resistomycin from a terrestrial actinomycete with TRAIL resistance-overcoming activity2018

    • Author(s)
      Liu, X.; Arai, M. A.; Toume, K.; Ishibashi, M.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 13 Pages: 65-66

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells2017

    • Author(s)
      Yoneyama Tatsuro、Arai Midori A.、Akamine Ryuta、Koryudzu Kazune、Tsuchiya Anna、Sadhu Samir K.、Ahmed Firoj、Itoh Motoyuki、Okamoto Ryuichi、Ishibashi Masami
    • Journal Title

      Journal of Natural Products

      Volume: 80 Issue: 9 Pages: 2453-2461

    • DOI

      10.1021/acs.jnatprod.7b00282

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Boesenberols I?K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity2017

    • Author(s)
      Karmakar Utpal K.、Arai Midori A.、Koyano Takashi、Kowithayakorn Thaworn、Ishibashi Masami
    • Journal Title

      Tetrahedron Letters

      Volume: 58 Issue: 40 Pages: 3838-3841

    • DOI

      10.1016/j.tetlet.2017.08.055

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Total Synthesis of Agalloside, Isolated from Aquilaria agallocha, by the 5-O-Glycosylation of Flavan2017

    • Author(s)
      Arai, M. A.*; Yamaguchi, Y.; Ishibashi, M.*
    • Journal Title

      Org. Biomol. Chem.

      Volume: 15 Issue: 23 Pages: 5025-5032

    • DOI

      10.1039/c7ob01004d

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Heterocyclic Flavonoids with Hedgehog Signal Inhibitory Activity2017

    • Author(s)
      Arai, M. A.*; Utsumi, T.; Yanase, N.; Fujimatsu, T.; Ishibashi, M.*
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 65 Issue: 8 Pages: 784-795

    • DOI

      10.1248/cpb.c17-00305

    • NAID

      130005875866

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hes1 binding compounds isolated by Target Protein Oriented Natural Products Isolation (TPO-NAPI)2017

    • Author(s)
      Arai, M. A.*; Tanaka, M.; Tanouchi, K.; Ishikawa, N.; Ahmed, F.; Sadhu, S. K.; Ishibashi, M.*
    • Journal Title

      J. Nat. Prod.

      Volume: 80 Issue: 2 Pages: 538-543

    • DOI

      10.1021/acs.jnatprod.6b01072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Isolation and evaluation of hedgehog inhibitors from Christmas grass (Themeda arguens)2017

    • Author(s)
      Yoneyama, T.; Arai, M. A.*; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      Heterocycles

      Volume: 印刷中 Issue: 1 Pages: 210-210

    • DOI

      10.3987/com-16-s(s)4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Valosin-containing Protein is a Target of 5'-l Fuligocandin B and Enhances TRAIL Resistance in Cancer Cells2016

    • Author(s)
      Arai, M. A.*; Taguchi, S.; Komatsuzaki, K.; Uchiyama, K.; Masuda, A.; Sampei, M.; Satoh, M.; Kado, S.; Ishibashi, M.*
    • Journal Title

      ChemistryOPEN

      Volume: 5 Issue: 6 Pages: 574-579

    • DOI

      10.1002/open.201600081

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cerasoidine, a bis-aporphine alkaloid isolated from Polyalthia cerasoides during screening for Wnt signal inhibitors2016

    • Author(s)
      Shono, T.; Ishikawa, N.; Toume, K.; Arai, M. A.; Masu, H.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 8 Pages: 2083-2088

    • DOI

      10.1021/acs.jnatprod.6b00409

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stereochemical assignment and biological evaluation of BE-14106 unveils the importance of one acetate unit for the antifungal activity of polyene macrolactams2016

    • Author(s)
      Fujita, K.; Sugiyama, R.; Nishimura, S.; Ishikawa, N.; Arai, M. A.; Ishibashi, M.; Kakeya, H.
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 7 Pages: 1877-1880

    • DOI

      10.1021/acs.jnatprod.6b00250

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Boesenberols, pimarane diterpenes with TRAIL resistance-overcoming activity from Boesenbergia pandurata2016

    • Author(s)
      Karmakar, U. K.; Ishikawa, N.; Arai, M. A.; Ahmed, F.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.
    • Journal Title

      J. Nat. Prod.

      Volume: 79 Issue: 8 Pages: 2075-2082

    • DOI

      10.1021/acs.jnatprod.6b00424

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species2016

    • Author(s)
      Abdelfatta, M. S., Arai, M. A., and Ishibashi, M.
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 7 Pages: 668-675

    • DOI

      10.1248/cpb.c16-00038

    • NAID

      130005160043

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities2016

    • Author(s)
      Arai, M. A.*; Kofuji, Y.; Tanaka, Y.; Yanase, N.; Yamaku, K.; Fuentes, R. G.; Karmakar, U. K.; Ishibashi, M.*
    • Journal Title

      Org. Biomol. Chem.

      Volume: 14 Issue: 11 Pages: 3061-3068

    • DOI

      10.1039/c5ob02537k

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hes1 dimer inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells2016

    • Author(s)
      Arai, M. A.*; Ishikawa, N.; Tanaka, M.; Uemura, K.; Sugimitsu, N.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*
    • Journal Title

      Chem. Sci.

      Volume: 7 Issue: 2 Pages: 1514-1520

    • DOI

      10.1039/c5sc03540f

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits Wnt signaling pathway by decreasing β-catenin mRNA expression2015

    • Author(s)
      Ohishi, K.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 18 Pages: 3937-3940

    • DOI

      10.1016/j.bmcl.2015.07.036

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hedgehog inhibitors from Withania somnifera2015

    • Author(s)
      Yoneyama, T.; Arai, M. A.*; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 17 Pages: 3541-3544

    • DOI

      10.1016/j.bmcl.2015.06.081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hedgehog inhibitors from Artocarpus communis and Hyptis suaveolens2015

    • Author(s)
      Arai, M. A.*; Uchida, K.; Sadhu, S. K.; Ahmed, F.; Koyano, T.; Kowithayakorn, T.; Ishibashi, M.*
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Issue: 15 Pages: 4150-4154

    • DOI

      10.1016/j.bmc.2015.06.058

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hedgehog/GLI- mediated transcriptional activity inhibitors from Crinum asiaticum2015

    • Author(s)
      Arai, M. A.*; Akamine, R.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.*
    • Journal Title

      J. Nat. Med.

      Volume: 69 Issue: 4 Pages: 538-542

    • DOI

      10.1007/s11418-015-0922-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Boehmenan, a lignan, isolated from Hibiscus ficulneus showed Wnt signal inhibitory activity2015

    • Author(s)
      Takumi Shono
    • Journal Title

      Bioorganic and Medicinal Chemistry Letters

      Volume: 25 Issue: 14 Pages: 2735-2738

    • DOI

      10.1016/j.bmcl.2015.05.037

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phenolic compounds from the bark of Oroxylum indicum identified as Ngn2 promoter activators2015

    • Author(s)
      Fuentes, R. G.; Arai, M. A.*; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.*
    • Journal Title

      J. Nat. Med.

      Volume: 78 Pages: 864-872

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 9-Hydorxycanthin-6-one, a β-carboline alkaloid from Eurycoma longifolia, is the first Wnt signal inhibitor through activation of GSK3β without depending on CK1α2015

    • Author(s)
      Ohishi, K.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Mizoguchi, T.; Itoh, M.; Ishibashi, M.
    • Journal Title

      J. Nat. Prod.

      Volume: 11 Issue: 5 Pages: 1139-1146

    • DOI

      10.1021/acs.jnatprod.5b00153

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa2015

    • Author(s)
      Fuentes, R. G.; Toume, K.; Arai, M. A.; Sadhu, S. K.; Ahmed, F.; Ishibashi, M.
    • Journal Title

      Phytochem. Lett.

      Volume: 11 Issue: 4 Pages: 280-285

    • DOI

      10.1007/s11418-015-0919-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inubosin A, B, and C are new acridine alkaloids isolated from Streptomyces sp. IFM 11440 that show Ngn2 promoter activity2015

    • Author(s)
      Midori A. Arai
    • Journal Title

      Journal of Natural Products

      Volume: 78 Issue: 2 Pages: 311-314

    • DOI

      10.1021/np5006218

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Naturally occurring FANCF-Hes1 complex inhibitors from Wrightia religiosa2015

    • Author(s)
      Midori A. Arai
    • Journal Title

      Med. Chem. Commun.

      Volume: 6 Issue: 3 Pages: 455-460

    • DOI

      10.1039/c4md00495g

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Natural compounds with Wnt signal modulating activity2015

    • Author(s)
      R. G. Fuentes, M. A. Arai, and M. Ishibashi
    • Journal Title

      Nat. Prod. Rep.

      Volume: 32 Issue: 12 Pages: 1622-1628

    • DOI

      10.1039/c5np00074b

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] TRAIL耐性克服作用を有する天然物furigocandin B誘導体の合成2017

    • Author(s)
      荒井緑,増田彩花,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Notchシグナル阻害作用を有する光学活性スピロ化合物の合成研究究2017

    • Author(s)
      荒井緑,岡野美優,荒井孝義,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経幹細胞分化を促進するHes1二量体形成阻害剤の合成研究2017

    • Author(s)
      荒井緑,山口祐未,石川直樹,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] リグナン骨格を有する神経幹細胞分化促進剤の創製研究2017

    • Author(s)
      三瓶真菜,荒井 緑,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Eugenia operculata等からのBMI1プロモーター阻害作用をもつ天然物の探索2017

    • Author(s)
      金田結,荒井緑,石川直樹,小谷野喬,T. Kowithayakorn, 千葉哲博,岩間厚志,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Celtis tetrandraとAmonum villosumからのTRAIL耐性克服作用をもつ天然物の探索2017

    • Author(s)
      P. Seephonkai, 荒井緑,石川直樹,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘテロ環を有するrocaglamide誘導体の合成と活性評価2017

    • Author(s)
      荒井緑,田中優貴,小藤悠貴,石橋正己
    • Organizer
      日本薬学会第137会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Approach to neural stem cells and cancer cells based on natural products2017

    • Author(s)
      M. A. Arai
    • Organizer
      The 4th Joint Symposium on Pharmaceutical Sciences between Graduate School of Pharmaceutical Sciences, Chiba University and College of Pharmacy, Seoul National University
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target identification and mode of action of 5’-I fuligocandin B with TRAIL-resistance overcoming activity2017

    • Author(s)
      M. A. Arai
    • Organizer
      Asian Chemical Biology Initiative 2017
    • Place of Presentation
      Ho Chi Minh, Vietnam
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 天然物を基盤とした生物活性分子の探索と創製2017

    • Author(s)
      荒井緑
    • Organizer
      東京工業大学 化学生命科学研究所講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Target identification and mode of action of 5’-I fuligocandin B with TRAIL-resistance overcoming activity2017

    • Author(s)
      M. A. Arai
    • Organizer
      WCCU-SMA Joint Symposium 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of rocaglamide derivatives with Wnt signal inhibition2017

    • Author(s)
      Y. Makita, M. A. Arai, Y. Tanaka, M. Ishibashi
    • Organizer
      The Second Symposium of Chiral Molecular Science and Technology in Chiba University
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Notch シグナル阻害作用を持つ放線菌代謝産物の成分探索2017

    • Author(s)
      合田芙二子,荒井緑,林奈留美,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Notchシグナル阻害作用を有する天然物の探索2017

    • Author(s)
      土屋杏奈,荒井緑,小谷野喬,T. Kowithayakorn,S. K. Sadhu, F. Ahmed, 石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ricinus communisとClinogyne dichotomaからのWntシグナル阻害作用をもつ天然物の探索2017

    • Author(s)
      佐藤知幸,荒井緑,S. K. Sadhu, F. Ahmed, 石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Amonum villosum等からのTRAIL耐性克服作用をもつ天然物の探索2017

    • Author(s)
      石川龍翔,Prapairat Seephonkai,荒井緑,S. K. Sadhu, F. Ahmed, 小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細胞毒性をもつMurraya paniculata抽出物からのクマリン型化合物の探索2017

    • Author(s)
      戸次雄一,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hes1二量体形成阻害活性を有する神経幹細胞分化活性化剤の探索2017

    • Author(s)
      盛田かおり,荒井緑,S. K. Sadhu, F. Ahmed, 石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nocardia属放線菌からの新規二次代謝産物の探索2017

    • Author(s)
      小林菜摘,原康雅,荒井緑,五ノ井透,矢口貴志,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放線菌二次代謝産物からのBMI1プロモーター阻害剤の探索2017

    • Author(s)
      横山夕将,荒井緑,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 動物細胞との共培養法による放線菌Nocardia属由来二次代謝産物の探索2017

    • Author(s)
      原康雅,荒井緑,五ノ井透,矢口貴志,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NICDビーズを用いたNotchシグナル阻害剤の探索2017

    • Author(s)
      林奈留美,荒井緑,菅波晃子,田村裕,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リグナン骨格を有する神経幹細胞分化促進剤の創成研究2017

    • Author(s)
      三瓶真菜,荒井緑,菅波晃子,田村裕,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wntシグナル阻害作用を有するロカグラミド誘導体の創成2017

    • Author(s)
      蒔田吉功,荒井緑,田中優貴,石橋正己
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Target Protein Oriented Natural Products Isolation (TPO-NAPI)2017

    • Author(s)
      M. A. Arai
    • Organizer
      The Second A3 Round Table Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ,Approach to neural stem cells and cancer cells based on natural products2017

    • Author(s)
      M. A. Arai
    • Organizer
      The 7th Sino-Japanese Symposium on Organic Chemistry for Young Scientists
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 天然物を基盤とした生物活性分子の探索と創製2017

    • Author(s)
      荒井緑
    • Organizer
      第一回函館セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] GLI1ビーズを用いたヘッジホッグシグナル阻害剤の探索2017

    • Author(s)
      越智富美江,荒井緑,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      第7回食品薬学シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Target Protein Oriented Natural Product Isolation2017

    • Author(s)
      M. A. Arai
    • Organizer
      Asian Chemical Biology Initiative 2017, Ulaanbaatar Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Notch シグナル阻害作用を有する光学活性スピロ化合物の創成研究2017

    • Author(s)
      岡野美優,荒井緑,荒井孝義,石橋正己
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] TRAIL 耐性克服作用を有する天然物fuligocandin B 誘導体の合成2017

    • Author(s)
      増田彩花,荒井緑,石橋正己
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wnt シグナル阻害作用を有するロカグラミド誘導体の創成2017

    • Author(s)
      蒔田吉功,荒井緑,田中優貴,石橋正己
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] リグナン骨格を有する神経幹細胞分化促進剤の創成研究2017

    • Author(s)
      三瓶真菜,荒井緑,石橋正己
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Wntシグナル阻害作用を有すうるロカグラミド誘導体の創成2017

    • Author(s)
      蒔田吉功,荒井緑,石橋正己
    • Organizer
      分子キラリティーセンターミーティング
    • Related Report
      2017 Annual Research Report
  • [Presentation] NICDビーズを用いたNotchシグナル阻害剤の探索2017

    • Author(s)
      林奈留美,荒井緑,石橋正己
    • Organizer
      日本ケミカルバイオロジー学会第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 天然由来Notchシグナル阻害剤によるがんへのアプローチ2017

    • Author(s)
      土屋杏奈,荒井緑,赤嶺隆太,岡本隆一,小谷野喬,Thaworn Kowithayakorn,Samir K. Sadhu,Firoj Ahmed,石橋正己
    • Organizer
      日本ケミカルバイオロジー学会第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NICDビーズを用いたNotchシグナル阻害剤の探索2017

    • Author(s)
      林奈留美,荒井緑,石橋正己
    • Organizer
      分子キラリティーセンターミーティング
    • Related Report
      2017 Annual Research Report
  • [Presentation] Synthesis of Hes1 homodimer inhibitors accelerating the differentiation of neural stem cells2016

    • Author(s)
      M. A. Arai, Y. Yamaguchi, N. Ishikawa, M. Ishibashi
    • Organizer
      2nd Joint Workshop on Chirality in Chiba University and Soft Molecule Activation
    • Place of Presentation
      千葉
    • Year and Date
      2016-12-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities2016

    • Author(s)
      M. A. Arai, Y. Tanaka, Y. Kofuji, T. Shono, K. Yamaku, M. Ishibashi
    • Organizer
      2nd Joint Workshop on Chirality in Chiba University and Soft Molecule Activation
    • Place of Presentation
      千葉
    • Year and Date
      2016-12-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物を基盤とした生物活性分子の探索と創製2016

    • Author(s)
      荒井緑
    • Organizer
      横浜市立大学2016年度教室セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 天然物を基盤とした生物活性分子の探索と創製2016

    • Author(s)
      荒井緑
    • Organizer
      明治薬科大学認知症創薬資源研究開発センター講習会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Search for BMI1 promoter inhibitors from Beaumontia murtonii and analysis of their mechanism2016

    • Author(s)
      Y. Kaneta, N. Ishikawa, M. A. Arai, K. Toume, T. Koyano, T. Kowithayakorn, T. Chiba, A. Iwama, M. Ishibashi
    • Organizer
      Institute for Global Prominent Research Kickoff Symposium
    • Place of Presentation
      千葉
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Target identification and mode of action of 5’-I fuligocandin B with TRAIL-resistance overcoming activity2016

    • Author(s)
      M. A. Arai, S. Taguchi, K. Komatsuzaki, K. Uchiyama, A. Masuda, M. Satoh, S. Kado, M. Ishibashi
    • Organizer
      International symposium on catalysis and fine chemicals 2016
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wntシグナル伝達経路を阻害するロカグラミド誘導体の合成研究2016

    • Author(s)
      荒井緑,田中優貴,小藤悠貴,山来一紀,石橋正己
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Beaumontia murtoniiなどからのBMI1プロモーター阻害剤の探索及び活性評価2016

    • Author(s)
      金田結,石川直樹,荒井緑,當銘一文,小谷野喬,T. Kowithayakorn, 千葉哲博,岩間厚志,石橋正己
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経幹細胞分化を促進するHes1二量体形成阻害剤の合成2016

    • Author(s)
      荒井緑,山口祐未,三瓶真菜,石川直樹,石橋正己
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Wntシグナル阻害活性を有するrocaglamide誘導体の合成研究2016

    • Author(s)
      荒井緑,田中優貴,小藤悠貴,山来一紀,庄野巧,石橋正己
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] GLI1ビーズを用いたヘッジホッグシグナル阻害剤の探索2016

    • Author(s)
      荒井緑,越智富美江,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経再生とがんの制御をめざした天然物基盤分子の創成研究2016

    • Author(s)
      荒井緑
    • Organizer
      第21回天然薬物の開発と応用シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 標的タンパク質指向型天然物単離による生物活性天然物の探索2016

    • Author(s)
      荒井緑,越智富美江,田中光葉,田内伽奈,石川直樹,小谷野喬,T. Kowithayakorn, S. K. Sadhu, F. Ahmed, 石橋正己
    • Organizer
      第46回複素環化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] GLI1ビーズを用いたヘッジホッグシグナル阻害剤の探索2016

    • Author(s)
      荒井緑,越智富美江,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第63年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pimarane diterpenes with TRAIL-resistance overcoming activity from Boesenbergia pandurata2016

    • Author(s)
      U. K. Karmakar,石川直樹,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本生薬学会第63年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Polyalthia cerasoidesからのWntシグナルを阻害する新規アルカロイド2016

    • Author(s)
      庄野巧,石川直樹,當銘一文,荒井緑,桝飛雄馬,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本生薬学会第63年会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] TRAIL耐性克服作用を有する5’-I Fuligocandin Bの標的タンパク質同定と作用機序解析2016

    • Author(s)
      荒井緑,田口翔大,小松﨑一裕,内山健人,増田彩花,佐藤守,荷堂清香,石橋正己
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経幹細胞分化を促進するHes1二量体形成阻害剤の合成2016

    • Author(s)
      荒井緑,山口祐未,三瓶真菜,石川直樹,石橋正己
    • Organizer
      分子キラリティー研究センターミーティング
    • Place of Presentation
      千葉
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Screening studies for natural products on disease and development pathways2016

    • Author(s)
      M. Ishibashi and M. A. Arai
    • Organizer
      International Symposium on Natural Products for the Future 2016 (ISNPF2016)
    • Place of Presentation
      徳島
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然物を基盤とした生物活性分子の探索と創製2016

    • Author(s)
      荒井緑
    • Organizer
      JSPS第189委員会 日本におけるケミカルバイオロジーの新展開
    • Place of Presentation
      東京
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Search for neural stem cell activators based on natural products2016

    • Author(s)
      M. A. Arai, T. Yoneyama, R. Akamine, R. Okamoto, T. Koyano, T. Kowithayakorn, S. K. Sadhu, F. Ahmed, M. Ishibashi
    • Organizer
      Molecular Chirality Asia 2016
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Polyalthia cerasoidesからのWntシグナルを阻害する天然物の探索2016

    • Author(s)
      庄野巧,石川直樹,當銘一文,荒井緑,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 放線菌からのHes1ビーズを用いた神経幹細胞分化を促進する天然物の探索2016

    • Author(s)
      荒井緑,田中光葉,石川直樹,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Garcinia speciosa等からのNotchシグナル阻害作用を有する天然物の探索2016

    • Author(s)
      荒井緑,赤嶺隆太,岡本隆一,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経幹細胞分化を促進するHes1二量体形成阻害剤の合成研究2016

    • Author(s)
      荒井緑,山口祐未,三瓶真菜,石川直樹,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヘテロ環を有するrocaglamide誘導体の合成と活性評価2016

    • Author(s)
      荒井緑,田中優貴,小藤悠貴,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Calotropis giganteaからのNotchシグナル伝達経路阻害を標的とした神経幹細胞分化促進剤の探索2016

    • Author(s)
      米山達朗,荒井緑,岡本隆一,Samir K. Sadhu,Firoj Ahmed,石橋正己
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Isolation of Notch inhibitors from Calotropis gigantea2016

    • Author(s)
      T. Yoneyama, M. A. Arai,R. Okamoto, S. K. Sadh,F. Ahmed,M. Ishibashi
    • Organizer
      Joint Workshop on Chirality in Chiba University (WCCU) and on Soft-Molecule Activation
    • Place of Presentation
      千葉大学 (千葉)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities2016

    • Author(s)
      M. A. Arai, Yuuki Tanaka, Yuuki Kofuji, Natsuki Yanase, Kazuki Yamaku, Rolly G. Fuentes, Masami Ishibashi
    • Organizer
      The First Symposium of Chiral Molecular Science and Technology in Chiba University
    • Place of Presentation
      千葉大学 (千葉)
    • Year and Date
      2016-02-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for neural stem cell activators based on natural products2016

    • Author(s)
      M. A. Arai
    • Organizer
      Asian Chemical Biology Initiative 2016 Jakarta Meeting
    • Place of Presentation
      Jakarta (Indonesia)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Search for Notch signaling inhibitors from natural products2015

    • Author(s)
      M. A. Arai, R. Akamine, R. Okamoto, T. Koyano, T. Kowithayakorn, S. K. Sadhu, F. Ahmed, M. Ishibashi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu (U.S.A.)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isolation of Notch inhibitors from Calotropis gigantea2015

    • Author(s)
      T. Yoneyama, M. A. Arai, R. Okamoto, S. K. Sadhu, F. Ahmed, M. Ishibashi
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu (U.S.A.)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放線菌ライブラリーの構築に基づくWntシグナル阻害作用をもつ天然物の探索2015

    • Author(s)
      山来一紀,石川直樹,當銘一文,荒井緑,石橋正己
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hibiscus ficulneusおよびPolyalthia cerasoidesからのWntシグナル阻害作用をもつ天然物の探索2015

    • Author(s)
      庄野巧,石川直樹,當銘一文,荒井緑,S. K. Sadhu,F. Ahmed,小谷野喬,T. Kowithayakorn,石橋正己
    • Organizer
      第6回食品薬学シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経幹細胞分化を促進するHes1二量体形成阻害剤の合成研究2015

    • Author(s)
      荒井緑,山口祐未,石川直樹,石橋正己
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Calotropis gigantea からのノッチシグナル伝達経路阻害剤の探索2015

    • Author(s)
      米山達朗,荒井緑,岡本隆一,S. K. Sadhu,F. Ahmed,石橋正己
    • Organizer
      日本生薬学会第61年会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Notch-Hes経路阻害を指標とする神経幹細胞分化活性化剤の探索2015

    • Author(s)
      荒井緑,赤嶺隆太,米山達朗,岡本隆一,小谷野喬,T. Kowithayakornd,石橋正己
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Scoparia dulcisから単離したウィントシグナル阻害作用をもつジテルペン2015

    • Author(s)
      Rolly G. Fuentes,當銘一文,荒井緑,Samir K. Sadhu,Firoj Ahmed,石橋正己
    • Organizer
      第59回香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経幹細胞分化活性化を目指した天然基盤分子の探索2015

    • Author(s)
      荒井緑
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」地区ミニシンポジウム・仙台「ケミカルバイオロジーにおける天然物」
    • Place of Presentation
      東北大学 (仙台)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 千葉大学大学院薬学研究院 活性構造化学研究室

    • URL

      http://www.p.chiba-u.jp/lab/kassei/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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