Creation of regeneration accelerating molecules using target protein oriented natural products isolation (TPO-NAPI)
| Project/Area Number |
15H04650
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Chiba University |
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Principal Investigator |
Arai Midori 千葉大学, 大学院薬学研究院, 准教授 (40373261)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIBASHI Masami 千葉大学, 大学院薬学研究院, 教授 (90212927)
KOUDA Masao 筑波大学, 医学医療系サイバニクス研究センター, 准教授 (50361449)
TAMURA Yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174)
ARAI Takayoshi 千葉大学, 大学院理学研究院, 教授 (80272483)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 幹細胞 / 天然物 / タンパク質ビーズ / ヘッジホッグ / ノッチ / Hes1 / 神経分化 / タンパク質 / 再生 / ケミカルバイオロジー |
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| Outline of Final Research Achievements |
Search for stem cells modulators has been done using screening system of natural resources extracts library. Bioactive natural products which bind on Hes1 (bHLH factor), GLI1 (Hedgehog signaling transcriptional factor) and NICD (Notch signaling transcriptional factor ) were efficiently found by using “target protein oriented natural products isolation (TPO-NAPI)”. In addition, bioactivity fractionation using cell-based reporter assay gave Notch signal inhibitors such as uscharin.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] 9-Hydorxycanthin-6-one, a β-carboline alkaloid from Eurycoma longifolia, is the first Wnt signal inhibitor through activation of GSK3β without depending on CK1α2015
Author(s)
Ohishi, K.; Toume, K.; Arai, M. A.; Koyano, T.; Kowithayakorn, T.; Mizoguchi, T.; Itoh, M.; Ishibashi, M.
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Journal Title
J. Nat. Prod.
Volume: 11
Issue: 5
Pages: 1139-1146
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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