Development of regenerative immunotherapy by using rhesus monkey model
| Project/Area Number |
15H04655
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Drug development chemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Kaneko Shin 京都大学, iPS細胞研究所, 准教授 (40361331)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
俣野 哲朗 国立感染症研究所, エイズ研究センター, センター長 (00270653)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
|
|---|
| Keywords | iPS細胞 / T細胞治療 / 免疫治療 / 安全性 / 非臨床安全性 / アカゲザル / 再生T細胞 / 自家移植 / 同種移植 / 細胞治療 / 再生医学 / 再生医療 / 免疫療法 / T細胞 / 非ヒト霊長類 / バイオ医薬品 / 評価モデル / 免疫再生 / 細胞分化T細胞 / 再分化T細胞 |
|---|
| Outline of Final Research Achievements |
Recent progress of T cell immunotherapy in cancer field enables us to also expect a T cell immunotherapy against fatal viral infections. In addition, iPS cell technology is also expected to realize a regenerative T cell immunotherapy and its further allogeneic application. In the study, as a process for safety development, we have established regenerated T cells from rhesus monkey iPS cells and transplanted them intravenously in autologous setting. Total five injection was performed to two rhesus monkeys. No acute and chronic adverse effects and tumorigenesis were observed during observation period in 2 years. We think that a part of safety data for a next step, allogeneic regenerative T cell transplantation model, has been obtained.
|
| Academic Significance and Societal Importance of the Research Achievements |
免疫細胞を用いた細胞医薬品について、ヒト細胞を移植できる免疫不全マウスを用いたとしても、ヒトでの体内動態（特に免疫連関）や副作用を予見することは容易でない。本研究で示したアカゲザルiPS細胞からのT細胞誘導と自家移植モデルは、ヒトiPS細胞由来T細胞の自家移植治療における体内動態や副作用を予見するのに有用であることが示唆された。非ヒト霊長類モデルによる非臨床試験は、今後のiPS細胞関連医薬品開発において重要な位置を占めると期待される。
|
Report
(4 results)
Research Products
(73 results)
-
-
-
-
-
-
-
-
[Journal Article] Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model.2016
Author(s)
Ishii, H., Matsuoka, S., Nomura, T., Nakamura, M., Shiino, T., Sato, Y., Iwata-Yoshikawa, N., Hasegawa, H., Mizuta, K., Sakawaki, H., Miura, T., Koyanagi, Y., Naruse, T.K., Kimura, A., and Matano, T.
-
Journal Title
Sci. Rep.
Volume: 6
Pages: 30153-30153
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Va24 Invariant NK T-like Cells from Human Induced Pluripotent Stem Cells2016
Author(s)
Kitayama S, Zhang R, Liu TY, Ueda N, Iriguchi S, Yasui Y, Kawai Y, Tatsumi M, Hirai N, Mizoro Y, Iwama T, Watanabe A, Nakanishi M, Kuzushima K, Uemura Y, Kaneko S
-
Journal Title
Stem Cell Reports
Volume: 6
Issue: 2
Pages: 213-227
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] BCR-ABL-specific CD4+ T helper cells promote the priming of antigen-specific cytotoxic T cells via dendritic cells.2016
Author(s)
Ueda N, Zhang R, Tatsumi M, Liu TY, Kitayama S, Yasui Y, Sugai S, Senju S, Kuzushima K, Kiyoi H, Kaneko S, Uemura Y.
-
Journal Title
Cellular and Molecular Immunology
Volume: In Press
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
[Presentation] Generation of CAR-iPS-T cells expressing CD8b.2017
Author(s)
Tatsuki Ueda, Shoichi Iriguchi, Yohei Kawai, Atsutaka Minagawa, Hiroyuki Miyoshi, Seitaro Terakura, Yasushi Uemura, Tetsuya Nakatsura,Koji Tamada, Knut Woltjen, Yuzo Kodama, Hiroshi Seno, Shin Kaneko.
Organizer
JSH International Symposium 2017
Related Report
-
-
-
-
-
-
[Presentation] Development of a preclinical monkey model for iPSC-based T cell immunotherapy.2017
Author(s)
Shoichi Iriguchi, Yasuyuki Miyake, Tomoyuki Miura, Ai Tachikawa, Tatsuki Ueda, Kahoru Taya, Eri Imai, HIroshi Ishii, Hirotaka Onoe, Tetsuro Matano, Shin Kaneko.
Organizer
第76回日本がん学会学術集会
Related Report
-
-
-
[Presentation] iPSC-based CAR-T therapy targeting for GPC3.2017
Author(s)
Tatsuki Ueda, Shoichi Iriguchi, Yohei Kawai, Atsutaka Minagawa1, Hiroyuki Miyoshi, Seitaro Terakura, Yasushi Uemura, Knut Woltjen,Yuzo Kodama, Koji Tamada,Tetsuya Nakatsura, Hiroshi Seno, Shin Kaneko.
Organizer
第76回日本がん学会学術集会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Generation of BCR-ABL Reactive CD4+ T Helper Cells By Reprograming and Redifferentiation.2015
Author(s)
Ueda N.,Uemura Y., Rhong Z., Kitayama S., Yasui Y., Tatsumi M., Liu T, Y., Kuzushima K., Kiyoi H., Naoe T., Kaneko S.
Organizer
The 57th ASH Annual Meeting and Exposition
Place of Presentation
Orland,USA
Year and Date
2015-12-07
Related Report
-
-
-
[Presentation] Generation of BCR-ABL reactive CD4 T lymphocytes by reprograming and redifferentiation.2015
Author(s)
Ueda N., Uemura Y., Rong Z., Kitayama S., Yasui Y., Tatsumi M., Liu T, Y., Kuzushima K., Kiyoi H., Kaneko S.
Organizer
第44回日本免疫学会学術総会
Place of Presentation
札幌
Year and Date
2015-11-19
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
