Research Project
Grant-in-Aid for Scientific Research (B)
Recent progress of T cell immunotherapy in cancer field enables us to also expect a T cell immunotherapy against fatal viral infections. In addition, iPS cell technology is also expected to realize a regenerative T cell immunotherapy and its further allogeneic application. In the study, as a process for safety development, we have established regenerated T cells from rhesus monkey iPS cells and transplanted them intravenously in autologous setting. Total five injection was performed to two rhesus monkeys. No acute and chronic adverse effects and tumorigenesis were observed during observation period in 2 years. We think that a part of safety data for a next step, allogeneic regenerative T cell transplantation model, has been obtained.
免疫細胞を用いた細胞医薬品について、ヒト細胞を移植できる免疫不全マウスを用いたとしても、ヒトでの体内動態（特に免疫連関）や副作用を予見することは容易でない。本研究で示したアカゲザルiPS細胞からのT細胞誘導と自家移植モデルは、ヒトiPS細胞由来T細胞の自家移植治療における体内動態や副作用を予見するのに有用であることが示唆された。非ヒト霊長類モデルによる非臨床試験は、今後のiPS細胞関連医薬品開発において重要な位置を占めると期待される。
All 2018 2017 2016 2015 Other
All Journal Article (15 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 6 results, Open Access: 7 results) Presentation (51 results) (of which Int'l Joint Research: 6 results, Invited: 25 results) Book (1 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)
最新医学
Volume: 73(2) Pages: 92-97
Clinical Neuroscience
Volume: 36(3) Pages: 338-341
Biochemical and Biophysical Research Communications
Volume: 497 Issue: 2 Pages: 719-725
10.1016/j.bbrc.2018.02.139
120006466601
小児内科
Volume: 49(7) Pages: 918-821
生物の科学「遺伝」
Volume: 71(5) Pages: 425-430
実験医学
Volume: 別冊 Pages: 278-279
日本臨牀
Volume: 75(2) Pages: 317-322
Sci. Rep.
Volume: 6 Pages: 30153-30153
120006346255
Methods Mol Biol.
Volume: 1393 Pages: 67-73
10.1007/978-1-4939-3338-9_6
臨床免疫・アレルギー科
Volume: 65(6) Pages: 315-620
40020884611
再生医療・細胞治療のための細胞加工物評価技術
Volume: - Pages: 229-239
Stem Cell Reports
Volume: 6 Issue: 2 Pages: 213-227
10.1016/j.stemcr.2016.01.005
Seminar in Immunology
Volume: In press Issue: 1 Pages: 71-78
10.1016/j.smim.2015.10.007
Cellular and Molecular Immunology
Volume: In Press
日本臨床免疫学会雑誌
Volume: 38（2） Pages: 101-108
130005072692
http://www.cira.kyoto-u.ac.jp/
http://www.cira.kyoto-u.ac.jp/kaneko/index.html
