| Project/Area Number |
15H04656
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MINAKAWA Noriaki 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (40209820)
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| Co-Investigator(Kenkyū-buntansha) |
石田 竜弘 徳島大学, 大学院医歯薬学研究部(薬学系), 教授 (50325271)
阿部 洋 名古屋大学, 理学研究科, 教授 (80415067)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 核酸創薬 / DNAデバイス / 化学合成 / RNAi創薬 |
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| Outline of Final Research Achievements |
In this study, research was conducted to further enhance the function of a DNA device (iRed) capable of expressing functional RNA in cells. As a result, (1) cyclization aimed at stabilizing iRed, (2) complete chemical synthesis of iRed, (3) searching for new cancer therapeutic drugs by combination with innovative delivery method, and (4) possibility to evolve this device to iPed expressing functional peptide peptide/protein were demonstrated.
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