Establishment of the basis for evolutional drug development toward avoidance of hypomagnesemia
| Project/Area Number |
15H04657
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
IKARI AKIRA 岐阜薬科大学, 薬学部, 教授 (50315850)
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| Co-Investigator(Kenkyū-buntansha) |
古田 巧 京都大学, 化学研究所, 准教授 (30336656)
遠藤 智史 岐阜薬科大学, 薬学部, 助教 (60433207)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 低Mg血症 / Mgチャネル / 細胞局在 / クローディン / バイオマーカー |
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| Outline of Final Research Achievements |
Hypomagnesemia causes discontinuation of treatment, but the mechanism of pathogenesis has not been fully clarified. In addition, there is no treatment method for hypomagnesemia. Drug discovery research may be delayed because the molecules of Mg2+ transporter were unknown. We investigated the abnormal mechanism of Mg2+ channel expression in hypomagnesemia and clarified the pathogenic mechanisms of drug-induced and inherited hypomagnesemia. In addition, we succeeded in identification of effective drugs for the treatment of hypomagnesemia. The present studies provide a development basis for a novel drug which prevents hypomagnesemia.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells2016
Author(s)
Shun Shimobaba, Saeko Taga, Risa Akizuki, Asami Hichino, Satoshi Endo, Toshiyuki Matsunaga, Ryo Watanabe, Masahiko Yamaguchi, Yasuhiro Yamazaki, Junko Sugatani, Akira Ikari
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Journal Title
Biochimica et Biophysica Acta
Volume: 1863
Issue: 6
Pages: 1170-1178
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells.2015
Author(s)
Ikari A, Taga S, Watanabe R, Sato T, Shimobaba S, Sonoki H, Endo S, Matsunaga T, Sakai H, Yamaguchi M, Yamazaki Y, Sugatani J.
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Journal Title
Biochim Biophys Acta.
Volume: 1848
Issue: 10
Pages: 2326-2336
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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