Protective effects of Shati/Nat8l on the dysfunction induced by addictive drugs

• Project/Area Number: 15H04662
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Nitta Atsumi 富山大学, 大学院医学薬学研究部(薬学), 教授 (20275093)
• Co-Investigator(Kenkyū-buntansha): 宮本 嘉明 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20449101) ; 宇野 恭介 富山大学, 大学院医学薬学研究部(薬学), 助教 (30608774)
• Co-Investigator(Renkei-kenkyūsha): MURAMATSU Shin-Ichi 自治医科大学, 教授 (10239543)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: Ｓｈａｔｉ／Ｎａｔ８ｌ / 危険ドラッグ / ＴＨＣ / メタンフェタミン / AAV / マウス / SHATI/NAT8L / THC / 薬物依存 / ケタミン / PF11 / ＣＲＥＢ / プロモーター / 依存性薬物 / 医薬品安全性 / 覚醒剤

Outline of Final Research Achievements

“Kiken Drugs” are including two type of chemical compounds, cathinone and cannabinoid derivatives. Shati/Nat8l was originally isolated from the nucleus accumbens of mice as a methamphetamine-related molecule. Since then, Shati/Nat8l has been characterized as an N-acetyltransferase 8-like protein that catalyzes N-acetylaspartate (NAA) synthesis from aspartate and acetyl- co enzyme A. The pharmacological effects of methamphetamine were inhibited in Shati/Nat8l-onverexpressed mice, in locomotor activity test and conditioned prederence tests. Tetrahydrocannabinol (THC) did not occur the significant dependent effects, but induced anxiety-like behaviors. The anxiety-like behaviors were not depressed in the Shati/Nat8l-onverexpressed mice. These results suggest that Shati/Nat8l has inhibitory effects on the phthe one type of “Kiken Drugs” ,but does not another.

Research Products

• [Int'l Joint Research] 瀋陽薬科大学(中国)
• [Int'l Joint Research] 瀋陽薬科大学(中国)
• [Int'l Joint Research] Graz University of Technology(オーストリア)
• [Journal Article] Shati/Nat8l knockout mice show behavioral deficits ameliorated by atomoxetine and methylphenidate (2018)
  • Author(s): Toriumi Kazuya、Tanaka Junko、Mamiya Takayoshi、Alkam Tursun、Kim Hyoung-Chun、Nitta Atsumi、Nabeshima Toshitaka
  • Journal Title: Behavioural Brain Research Volume: 339 Pages: 207-214
  • DOI: 10.1016/j.bbr.2017.11.040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of transmembrane protein 168 in the mouse nucleus accumbens induces anxiety and sensorimotor gating deficit (2017)
  • Author(s): Fu Kequan、Miyamoto Yoshiaki、Sumi Kazuyuki、Saika Eriko、Muramatsu Shin-ichi、Uno Kyosuke、Nitta Atsumi
  • Journal Title: PLOS ONE Volume: 12 Issue: 12 Pages: e0189006-e0189006
  • DOI: 10.1371/journal.pone.0189006
  • NAID: 120006402038
  • Peer Reviewed / Open Access
• [Journal Article] Behavioral impairment in SHATI/NAT8L knockout mice via dysfunction of myelination development (2017)
  • Author(s): Sumi Kazuyuki、Uno Kyosuke、Noike Hiroshi、Tomohiro Takenori、Hatanaka Yasumaru、Furukawa-Hibi Yoko、Nabeshima Toshitaka、Miyamoto Yoshiaki、Nitta Atsumi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 16872-16872
  • DOI: 10.1038/s41598-017-17151-1
  • NAID: 120006402037
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of the accumbal osteopontin-interacting transmembrane protein 168 in methamphetamine-induced place preference and hyperlocomotion in mice (2017)
  • Author(s): Fu Kequan、Miyamoto Yoshiaki、Otake Kazuya、Sumi Kazuyuki、Saika Eriko、Matsumura Shohei、Sato Naoki、Ueno Yuka、Seo Seunghee、Uno Kyosuke、Muramatsu Shin-ichi、Nitta Atsumi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 13084-13084
  • DOI: 10.1038/s41598-017-13289-0
  • NAID: 120006402035
  • Peer Reviewed / Open Access
• [Journal Article] Striatal N-Acetylaspartate Synthetase Shati/Nat8l Regulates Depression-Like Behaviors via mGluR3-Mediated Serotonergic Suppression in Mice (2017)
  • Author(s): Miyamoto Yoshiaki、Iegaki Noriyuki、Fu Kequan、Ishikawa Yudai、Sumi Kazuyuki、Azuma Sota、Uno Kyosuke、Muramatsu Shin-ichi、Nitta Atsumi
  • Journal Title: International Journal of Neuropsychopharmacology Volume: 20 Issue: 12 Pages: 1027-1035
  • DOI: 10.1093/ijnp/pyx078
  • NAID: 120006402036
  • Peer Reviewed / Open Access
• [Journal Article] The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization (2017)
  • Author(s): Akihiro Mouri, Yukihiro Noda, Minae Niwa, Yurie Matsumoto, Takayoshi Mamiya, Atsumi Nitta, Kiyofumi Yamada, Shoei Furukawa, Tatsunori Iwamura, Toshitaka Nabeshima
  • Journal Title: Behavioural Brain Research Volume: 329 Pages: 157-165
  • DOI: 10.1016/j.bbr.2017.04.052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Methamphetamine induces (2017)
  • Author(s): Uno K, Miyazaki T, Sodeyama K, Miyamoto Y, Nitta A.
  • Journal Title: PLoS One Volume: 12 Issue: 3 Pages: e0174196-e0174196
  • DOI: 10.1371/journal.pone.0174196
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analysis of pharmacist-patient communication using the Roter Method of Interaction Process Analysis System. (2016)
  • Author(s): Nakayama C, Kimata S, Oshima T, Kato A, Nitta A.
  • Journal Title: Res Social Adm Pharm Volume: 12 Issue: 2 Pages: 319-526
  • DOI: 10.1016/j.sapharm.2015.05.007
  • NAID: 120006383329
  • Peer Reviewed / Open Access
• [Journal Article] Pseudoginsenoside-F11 inhibits methamphetamine-induced behaviors by regulating dopaminergic and GABAergic neurons in the nucleus accumbens (2016)
  • Author(s): Fu K, Lin H, Miyamoto Y, Wu C, Yang J, Uno K, Nitta A
  • Journal Title: Psychopharmacology (Berl) Volume: 235 Issue: 5 Pages: 831-840
  • DOI: 10.1007/s00213-015-4159-8
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased DNA methylation in the Shati/Nat8l promoter in both patients with schizophrenia and a methamphetamine-induced murine model of schizophrenia-like phenotype (2016)
  • Author(s): Uno K, Kikuchi Y, Iwata M, Uehara T, Matsuoka T, Sumiyoshi T, Okamoto Y, Jinno H, Takada T, Furukawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
  • Journal Title: PLoS One Volume: 11 Issue: 6 Pages: e0157959-e0157959
  • DOI: 10.1371/journal.pone.0157959
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 依存症の分子病態解析 (2016)
  • Author(s): 新田淳美、宇野恭介、鍋島俊隆、宮本嘉明
  • Journal Title: 脳21 Volume: 19 Pages: 39-42
• [Journal Article] Deletion of SHATI/NAT8L decreases the N-acetylaspartate content in the brain and induces behavioral deficits, which can be ameliorated by administering N-acetylaspartate. (2015)
  • Author(s): Toriumi K, Mamiya T, Song Z, Honjo T, Watanabe H, Tanaka J, Kondo M, Mouri A, Kim HC, Nitta A, Fukushima T, Nabeshima T.
  • Journal Title: Eur Neuropsychopharmacol. Volume: 25(11) Issue: 11 Pages: 2108-17
  • DOI: 10.1016/j.euroneuro.2015.08.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Induction of neuronal axon outgrowth by Shati/Nat8l by energy metabolism in mice cultured neurons. (2015)
  • Author(s): Sumi K, Uno K, Matsumura S, Miyamoto Y, Furukawa-Hibi Y, Muramatsu S, Nabeshima T, Nitta A.
  • Journal Title: Neuroreport Volume: 26(13) Issue: 13 Pages: 740-746
  • DOI: 10.1097/wnr.0000000000000416
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study. (2015)
  • Author(s): Uno K, Nishizawa D, Seo S, Takayama K, Matsumura S, Sakai N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Hasegawa J, Sato N, Tanioka F, Sugimura H, Fukuda KI, Higuchi S, Ujike H, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Yamada M, Ikeda K, Miyamoto Y, Nitta A.
  • Journal Title: Curr Mol Med Volume: 15 Pages: 265-274
  • Peer Reviewed
• [Journal Article] Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: compatibility study with morphine and metoclopramide injections. (2015)
  • Author(s): Tanabe K, Wada J, Ohkubo J, Nitta A, Ikezaki T, Takeuchi M, Handa A, Tanaka M, Murakami N, Kashii T, Kitazawa H.
  • Journal Title: Eur J Hosp Pharm Sci Pract Volume: 22 Pages: 171-175
  • Peer Reviewed
• [Journal Article] Pubertal administration of antiserum against nerve growth factor regresses renal vascular remodeling in spontaneously hypertensive rats. (2015)
  • Author(s): Ohara M, Tomoda F, Koike T, Liu H, Uno K, Nitta A, Inoue H.
  • Journal Title: Clin Exp Pharmacol Physiol. Volume: 42 Issue: 6 Pages: 687-694
  • DOI: 10.1111/1440-1681.12411
  • NAID: 120006383330
  • Peer Reviewed
• [Journal Article] Development of a communication learning program for pharmacists (2015)
  • Author(s): Nakayama C, Oshima T, Kato A, Nitta A
  • Journal Title: Jap J Pharm Health Care Sci Volume: 41 Pages: 80-92
  • NAID: 130005125779
  • Peer Reviewed
• [Presentation] 医療機器材に関する学習補助用映像資材の開発と評価 (2017)
  • Author(s): 田辺公一, 折笠秀樹, 西谷美幸, 八塚美樹, 安田智美, 新田淳美, 細谷健一
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] マウス側坐核でのTMEM168過剰発現は、ドパミン機能調節を介して覚醒剤誘発行動を制御する, (2017)
  • Author(s): 宮本嘉明, 傅柯ぜん, 大竹和弥, 鷲見和之, 斉鹿絵里子, 松村祥平, 村松慎一, 宇野恭介, 新田淳美
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] 前頭前皮質Piccoloノックダウンマウスにおけるマイルドストレス暴露は、うつ様行動を誘発する (2017)
  • Author(s): 濱谷康平, 宮本嘉明, 稲垣良, 佐藤慶治, 村松慎一, 宇野恭介, 新田淳美
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] Shati KOマウスは不安作用が減少し、学習能力には雌雄差がある (2017)
  • Author(s): 宇野恭介, 鷲見和之, Haddar, Meriem, 村松慎一, 宮本嘉明, 新田淳美
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
• [Presentation] 新規分子Shati/Nat8Lの多彩な機能についてー薬物依存・精神機能ー (2017)
  • Author(s): 新田淳美
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] nduction system of Shati/Nat8L expression by methamphetamine via dopamine D1 signaling pathway (2017)
  • Author(s): Uno K, Miyazaki T, Miyamoto Y, Nitta A
  • Organizer: The 5th Congress of AsCNP 2017
  • Int'l Joint Research
• [Presentation] The combination of presynaptic cytomatrix protein Piccolo knockdown in the prefrontal cortex and mild social defeat stress induces schizophrenia-like behaviors in mice (2017)
  • Author(s): Miyamoto Y, Hamatani K, Inagaki R, Sato K, Muramatu SI, Nabeshima T, Uno K, Nitta A.
  • Organizer: The 5th Congress of AsCNP 2017
  • Int'l Joint Research
• [Presentation] Novel molecules, Shati/Nat8l, Piccolo and TMEM168, protect methamphetamine dependence in mice. Joint AsCNP-ASNP meeting (JM02 Addiction research collaborations in Asia) (2017)
  • Author(s): Nitta A
  • Organizer: The 5th Congress of AsCNP 2017
  • Int'l Joint Research / Invited
• [Presentation] Study of Teneurin-4 function to establish the bipolar disease mice model using CRISPR-Cas9 system (2017)
  • Author(s): Miyashita M, Uno K, Nakano F, Nishizono H, Muramatsu SI , Miyamoto Y, Nitta A
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Effects of SHATI/NAT8L overexpression in the striatum on social stress sensitivity in mice (2017)
  • Author(s): Miyanishi H, Uno K, Miyazaki T, Sodeyama K, Fuziwara T, Muramatsu SI , Miyamoto Y, Nitta A
  • Organizer: 第60回日本神経化学会大会
• [Presentation] Enhanced locomotor activity and impaired prepulse inhibition induced by presynaptic cytomatrix protein Piccolo knockdown in the amygdala of mice (2017)
  • Author(s): Hamatani K, Miyamoto Y, Oketani Y, Muramatsu SI , Uno K, Nitta A
  • Organizer: 第60回日本神経化学会大会
• [Presentation] マウス線条体でのShati/Nat8l過剰発現によるセロトニン神経系を介する情動性調節 (2017)
  • Author(s): 東 颯太, 宮本嘉明, 家垣典幸, 傅 柯ぜん;, 鷲見和之, 石川雄大, 村松慎一, 宇野恭介, 新田淳美
  • Organizer: 第68回薬理学会北部会
• [Presentation] 幼若期のミエリン形成の遅延による SHATI/NAT8L KOマウスの社会性低下や不安作用の増大 (2017)
  • Author(s): 新田淳美, 鷲見和之, 友廣岳則, 畑中保丸, 日比陽子, 宮本嘉明, 鍋島俊隆, 宇野恭介
  • Organizer: 第39回 日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
• [Presentation] 依存性薬物の薬理作用発現を抑制する分子群 行動薬理学的・生化学的研究 シンポジウム19依存性薬物の光と影 (2017)
  • Author(s): 新田淳美
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
  • Invited
• [Presentation] Shati/Nat8l is a key molecule in onset of addiction and psychiatric diseases (2017)
  • Author(s): Atsumi Nitta
  • Organizer: International Symposium Ｉｎｉｔｉａｔｉｖｅ ｆｏｒ Ｒｅａｌｉｚｉｎｇ Ｄivｅｒｓｉｔｙ ｉｎ ｔｈｅ
  • Place of Presentation: Toyama
  • Int'l Joint Research
• [Presentation] 薬剤師としての薬学部での研究 (2017)
  • Author(s): 新田淳美
  • Organizer: 富山から世界へ～女性研究者の視点から～
  • Place of Presentation: 富山
• [Presentation] 7.N-acetylaspartate synthetase Shati/Nat8l-overexpressed mice (2016)
  • Author(s): Miyamoto Y, Fu K, Iegaki N, Sumi K, Furukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K, Nitta A,
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] 8.Effects of TMEM168 overexpression on methamphetamine-induced hyperlocomotion and place preference, and anxiety in mice via regulating dopaminergic and GABAergic neuronal systems in the nucleus accumbens of mice (2016)
  • Author(s): Fu K, Miyamoto Y, Saika E, Muramatsu S, Uno K, Nitta A
  • Organizer: Neuroscience 2016
  • Place of Presentation: San Diego
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] マウス側坐核におけるPiccoloノックダウンのドパミン遊離とメタンフェタミン誘発行動抑制作用 (2016)
  • Author(s): 宇野恭介, 葛斌, 村松慎一, 日比陽子, 鍋島俊隆, 宮本嘉明, 新田淳美
  • Organizer: 平成28年度日本アルコール・アディクション医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2016-10-07
• [Presentation] Methamphetamine responses are attenuated by pseudoginsenoside-F11 with changes in the dopaminergic and GABAergic functions in the nucleus accumbens of mice (2016)
  • Author(s): Miyamoto Y, Lin H, Wu C, Yang J, Uno K, Nitta A
  • Organizer: TAA-Pharm Symposium
  • Place of Presentation: Toyama
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] Recovery of behavioral deficits in SHATI/NAT8L knockout mice via treatment of acetate in the brain development stage (2016)
  • Author(s): Sumi K, Uno K, Tomohiro T, Hatanaka Y, Furujawa-Hibi Y, Nabeshima T, Miyamoto Y, Nitta A
  • Organizer: TAA-Pharm Symposium,
  • Place of Presentation: Toyama
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] マウス側坐核におけるShati/Nat8Lの発現制御メカニズムの解析 (2016)
  • Author(s): 宇野恭介, 宮崎杜夫, 宮本嘉明, 新田淳美
  • Organizer: 第38回日本生物学的精神医学会・第59回日本神経化学大会
  • Place of Presentation: 福岡
  • Year and Date: 2016-09-08
• [Presentation] .薬学系大学院教育におけるインターンシップについて－富山大学薬学系大学院で実施している製薬企業・病院薬剤師でのインターンシップ－ (2016)
  • Author(s): 新田淳美, 細谷健一, 新山雅夫, 松原利行, 龍伸和, 周徳軍, 徐承姫, 済木育夫, 柴原利直, 門脇真, 今中常雄
  • Organizer: 第1回日本薬学教育学会大会
  • Place of Presentation: 京都
  • Year and Date: 2016-08-27
• [Presentation] .新規分子Shati/Nat8lの基礎研究成果をもととしたトランスレーショナルリサーチ (2016)
  • Author(s): 新田淳美
  • Organizer: 第18回応用薬理シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2016-08-05
  • Invited
• [Presentation] マウス線条体でのN-アセチルアスパラギン酸合成酵素Shati/Nat8l過剰発現によるうつ病モデル動物の開発 (2016)
  • Author(s): 宮本嘉明, 家垣典幸, 傅柯ぜん, 鷲見和之, 村松慎一, 鍋島俊隆, 宇野恭介, 新田淳美
  • Organizer: 第13回うつ病学会総会
  • Place of Presentation: ソウル
  • Year and Date: 2016-08-05
• [Presentation] 精神疾患関連遺伝子Shati/Nat8lの遺伝子発現メカニズムの解析 (2016)
  • Author(s): 宇野恭介, 宮崎杜夫, 宮本嘉明, 袖山健吾, 新田淳美
  • Organizer: 第18回応用薬理シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2016-08-05
• [Presentation] 新規精神活動制御分子Shati/Nat8lの生理機能解明 (2016)
  • Author(s): 新田淳美
  • Organizer: 応用薬理シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2016-08-04
  • Invited
• [Presentation] Overexpression of Shati/Nat8l in the dorsal striatum induces depression-like behaviors in mice (2016)
  • Author(s): Sodeyama K, Fuzisawa K, Miyazaki T, Uno K, Muramatsu S, Nabeshima T, Miyamoto Y, Nitta A,
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Soeul
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] .Pseudoginsenoside-F11 inhibits methamphetamine dependence by regulating GABAergic and opioidergic neuronal system in the nucleus accumbens of mice (2016)
  • Author(s): Fu K, Miyamoto Y, Lin H, Wu C, Yang J, Uno K, Nitta A
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology,
  • Place of Presentation: Seoul
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] .Presynaptic protein Piccolo knockdown in the prefrontal cortex induces cognitive and emotional impairment in mice (2016)
  • Author(s): Miyamoto Y, Inagaki R, Sato K, Muramatsu S, Nabeshima T, Uno K, Nitta A
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Soeul
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] 10.前頭前皮質のプレシナプス細胞質マトリックスタンパク質Piccoloと精神疾患様行動との関連 (2016)
  • Author(s): 宮本嘉明, 稲垣良, 佐藤慶治, 村松慎一, 鍋島俊隆, 宇野恭介, 新田淳美
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル
  • Year and Date: 2016-07-02
• [Presentation] マウス背側線条体におけるN-アセチル転移酵素Shati/Nat8Lの過剰発現のうつ様行動増強作用, (2016)
  • Author(s): 袖山健吾, 藤原俊幸, 宮崎杜夫, 宇野恭介, 村松慎一, 鍋島俊隆, 宮本嘉明, 新田淳美
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル
  • Year and Date: 2016-07-02
• [Presentation] マウス側坐核におけるピッコロノックダウンによるメタンフェタミン薬理作用への抑制効果 (2016)
  • Author(s): 葛斌, 森下誠也, 宇野恭介, 村松慎一, 鍋島俊隆, 宮本嘉明, 新田淳美
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル
  • Year and Date: 2016-07-02
• [Presentation] .メタンフェタミン誘発行動異常に対するドパミンおよびGABA作動性神経系を介したアメリカ人参成分Pseudoginsenoside-F11の抑制作用 (2016)
  • Author(s): 傅柯ぜん;, 宮本嘉明, 林彗洋, 呉 春福, 楊静玉, 宇野恭介, 新田淳美
  • Organizer: 第46回日本神経精神薬理学会
  • Place of Presentation: ソウル
  • Year and Date: 2016-07-02
• [Presentation] マウスin vivoマイクロダイアリシス法を用いた薬物依存研究 (2016)
  • Author(s): 新田淳美
  • Organizer: 第55回日本生体医工学会大会
  • Place of Presentation: 富山
  • Year and Date: 2016-04-26
  • Invited
• [Presentation] ドパミンおよびGABA作動性神経系を介するアメリカ人参由来サポニンPF11のメタンフェタミンによる行動変化への抑制作用 (2016)
  • Author(s): 傅柯ゼン, 宮本嘉明, 呉春福, 楊静玉, 新田 淳美
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] 精神疾患におけるプレシナプス性タンパク質Piccoloの関連 (2016)
  • Author(s): 佐藤慶治, 宮本嘉明, 稲垣良, 袖山健吾, 村松慎一, 鍋島俊隆, 新田淳美
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] メタンフェタミン誘発行動変化とドパミン遊離をマウス側坐核でのピッコロノックダウンは抑制する (2016)
  • Author(s): 葛 斌, 宇野 恭介, 森下 誠也, 村松 慎一, 宮本 嘉明, 新田 淳美
  • Organizer: 第89回日本薬理学会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
• [Presentation] .Knockdown Piccolo suppressed Methamphetamine-induced behavioral changes and dopamine release in the nucleus accumbens of mice (2016)
  • Author(s): Ge B, Morishita S, Uno K, Muramatsu S, Nabeshima T, Miyamoto Y, Nitta A,
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Soeul
  • Int'l Joint Research
• [Presentation] .マウス線条体におけるShati/Nat8l過剰発現のうつ病発症に対する脆弱性形成作用, 口頭 (2016)
  • Author(s): 袖山健吾, 宮崎杜夫, 宇野恭介, 鷲見和之, 藤原俊幸, 村松慎一, 宮本嘉明, 新田淳美
  • Organizer: 第67回日本薬理学会北部会
  • Place of Presentation: 札幌
• [Presentation] 薬物依存形成メカニズムにおける膜貫通タンパク質TMEM168の関与 (2016)
  • Author(s): 大竹和弥, 宮本嘉明, 傅柯ぜん, 徐承姫, 上野優香, 齋鹿絵里子, 村松慎一, 宇野恭介, 新田淳美
  • Organizer: 第67回日本薬理学会北部会
  • Place of Presentation: 札幌
• [Presentation] Shati/Nat8l is a key molecule in onset of addivtion and psychiatric diseases (2016)
  • Author(s): Ａｔｓｕｍｉ Nitta
  • Organizer: 2016 China-Japan-Korea Joint Symposium “Clinical Pharmacology & Neuropharmacology
  • Place of Presentation: Soeul
  • Int'l Joint Research / Invited
• [Presentation] Docetaxelによる爪障害発現時期および重篤化の新規予測因子 (2015)
  • Author(s): 16.高畑英信, 田辺公一, 高木昭佳, 久田勢津子, 山之内恒昭, 三村康彦, 新田淳美, 安田初奈, 菓子井達彦, 足立伊左雄
  • Organizer: 第25回日本医療薬学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2015-11-11
• [Presentation] ドパミン神経系におけるN-アセチルトランスフェラーゼShati/Nat8lを介した機能制御メカニズム (2015)
  • Author(s): 宮本嘉明, 宇野恭介, 鍋島俊隆, 新田淳美
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-11
• [Presentation] Accumbal TMEM168 overexpression in mice inhibits methamphetamine-induced hyperlocomotion and CPP (2015)
  • Author(s): Kequan Fu, Yoshiaki Miyamoto, Eriko Saika, Shin-ichi Muramatsu, Kyosuke Uno, Atsumi Nitta
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2015-10-11
• [Presentation] Analysis of pharmacist-patient communication using the roter method of interaction process annalysis system (2015)
  • Author(s): Oshima T, Nakayama C, Kato A, Nitta A
  • Organizer: The 75th FIP World Congress of Pharmacy and Pharmaceutical Sciences 2015
  • Place of Presentation: Dusseldorf
  • Year and Date: 2015-09-29
  • Int'l Joint Research
• [Presentation] 精神疾患患者における末梢血中SHATI/NAT8LのDNAメチル化率の低下 (2015)
  • Author(s): 岩田美奈, 宇野恭介 ,宮崎杜夫, 袖山健吾, 山森英長, 藤本美智子, 安田由華, 橋本亮太, 宮本嘉明, 鍋島俊隆, 武田雅俊, 新田淳美
  • Organizer: 第45回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] マウス前頭前皮質での Piccolo ノックダウンによるシナプス機能障害 (2015)
  • Author(s): 宮本嘉明, 佐藤慶治, 稲垣良, 村松慎一, 鍋島俊隆, 宇野恭介, 新田淳美
  • Organizer: 第45回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
• [Presentation] マウス前頭前皮質におけるPiccolo 発現低下による統合失調症様行動の誘導 (2015)
  • Author(s): 新田淳美
  • Organizer: 第45回日本神経精神薬理学会年会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-24
  • Invited
• [Presentation] 培養神経細胞における精神疾患関連分子Shati/Nat8lの突起伸長への影響 (2015)
  • Author(s): 宇野恭介, 鷲見和之, 松村祥平, 宮本嘉明, 古川-日比陽子, 鍋島俊隆, 村松慎一,新田淳美
  • Organizer: 第66回日本薬理学会北部
  • Place of Presentation: 富山
  • Year and Date: 2015-09-18
• [Presentation] Shati/Nat8l induces axon outgrowth via energy metabolism in the primary cultured neurons of mice (2015)
  • Author(s): Nitta Atsumi, Sumi Kazuyuki, Uno Kyosuke, Matsumura Shohei, Miyamoto Yoshiaki, Furukawa-Hibi Yoko, Muramatsu Shin-ichi, Nabeshima Toshitaka
  • Organizer: 第58回日本神経化学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2015-09-11
• [Presentation] マウス前頭前皮質におけるPiccoloの発現低下による神経機能障害 (2015)
  • Author(s): 新田淳美, 稲垣良, 佐藤慶治, 村松慎一, 鷲見和之, 鍋島俊隆, 宇野恭介, 宮本嘉明
  • Organizer: 生体機能と創薬シンポジウム2015
  • Place of Presentation: 船橋
  • Year and Date: 2015-08-27
• [Presentation] 新規分子Shtai/Nat8lによる薬物依存および精神疾患の治療を目指すためのストラテジー (2015)
  • Author(s): 新田淳美, 宮崎杜夫, 岩田美奈, 菊地佑, 袖山健吾, 宇野恭介
  • Organizer: 医療薬学フォーラム2015
  • Place of Presentation: 名古屋
  • Year and Date: 2015-07-04
  • Invited
• [Book] Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans IN“Nicotinic Acetylcholine Receptor Signaling in Neuroprotection (2018)
  • Author(s): Nitta A, Noike H, Sumi K, Miyanishi H, Tanaka T, Nagakura M, Iegaki N, Kaji JI, Miyamoto Y, Muramatsu SI, Uno K.
  • Total Pages: 191
  • Publisher: Springer Nature
  • ISBN: 9789811084874
• [Book] 脳21 (2016)
  • Author(s): 新田淳美、宇野恭介、鍋島俊隆、宮本嘉明
  • Total Pages: 92
  • Publisher: 金芳堂
• [Remarks] 富山大学薬学部薬物治療学研究室ホームページ
  • URL: http://www.pha.u-toyama.ac.jp/yakuchi/top.html
• [Remarks] こころの病を探求する
  • URL: http://sai-jisedai.jugem.jp/
• [Remarks] 富山大学大学院医学薬学研究部（薬学）・薬物治療学研究室ホームページ
  • URL: http://www.pha.u-toyama.ac.jp/laboratory/yakuchi/index.html
• [Remarks] 富山大学教員総覧 新田淳美
  • URL: http://evaweb.u-toyama.ac.jp/html/386_ja.html
• [Remarks] こころの病気を探求する
  • URL: http://sai-jisedai.jugem.jp/
• [Patent(Industrial Property Rights)] 特許 (2017)
  • Inventor(s): 新田淳美、鷲見和之、野池悠、宇野恭介
  • Industrial Property Rights Holder: 国立大学法人富山大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Acquisition Date: 2018
• [Patent(Industrial Property Rights)] プロポリスのミセル化抽出物を有効成分とする認知機能改善剤 (2016)
  • Inventor(s): 新田淳美, 鷲見和之, 野池悠, 宇野恭介
  • Industrial Property Rights Holder: 富山大学長
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-08-02