| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Chronic allograft nephropathy (CAN) after kidney transplantation results in dysfunction like chronic kidney disease with advanced fibrosis. In order to overcome CAN in kidney transplantation therapy, urinary biomarkers leading to fibrosis of transplanted kidney tissue were examined. By use of urine and blood samples from 73 patients after renal transplantation, and analyzed the relationship between urinary biomarker candidate protein and clinical course and analyzed with tissue damage mainly including acute rejection and tubularitis found after 3 months postoperative course were shown. As a result, the urinary NGAL, MCP-1 and LC3 were shown as an useful index for early prediction of CNI-induced renal impairment after renal transplantation.
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