Analysis of molecular mechanisms of retinal neuron development
| Project/Area Number |
15H04669
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 網膜 / 細胞分化 / 視覚 / 転写因子 / エピジェネテティック / 視細胞 / 分化 / エピジェネティック / ヒストン修飾 / 脳・神経 / 発生・分化 / 神経科学 / 遺伝子 / 神経 / ニューロン / 網膜変性 / 再生 |
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| Outline of Final Research Achievements |
We have studied molecular mechanisms underlying retinal photoreceptor development, synapse formation, and retinal degeneration. In the current study, as a model system to study vertebrate central nervous system development, we have analyzed cell fate determination of retinal photoreceptor cells. We found that transcriptional regulation and epigenetic mechanisms play crucial roles in retinal neuronal differentiation and maturation.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular reminiscent of Mowat-Wilson syndrome with Ehlers-Danlos syndrome.2017
Author(s)
Teraishi M, Takaishi M, Nakajima K, Ikeda M, Higashi Y, Shimoda S, Asada Y, Hijikata A, Ohara O, Hirai Y, Mizuno S, Fukada T, Furukawa T, Wakamatsu N, Sano S.
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Journal Title
Scientific Report
Volume: 7:46565
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Loss of ift122, a Retrograde Intraflagellar Transport (IFT) Complex Component, Leads to Slow, Progressive Photoreceptor Degeneration Due to Inefficient Opsin Transport.2016
Author(s)
Boubakri M, Chaya T, Hirata H, Kajimura N, Kuwahara R, Ueno A, Malicki J, Furukawa T, Omori Y
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Journal Title
The Journal of Biological Chemistry
Volume: 291
Issue: 47
Pages: 24465-24474
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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