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Study on TRIC channel and MG56

Research Project

Project/Area Number 15H04676
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionKyoto University

Principal Investigator

Takeshima Hiroshi  京都大学, 薬学研究科, 教授 (70212024)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
KeywordsTRICチャネル / ミツグミン56 / 生理学 / 骨芽細胞 / 小胞体 / MG56
Outline of Final Research Achievements

The muscle sarcoplasmic reticulum (SR) is a unique organelle specialized for Ca2+ handling, and we have identified TRIC channels and MG56 as SR component proteins. This research project has been designed to examine the physiological roles of the SR components, and yielded several novel results partly described below. We identified the pathological mechanism underlying TRIC-B-mutated osteogenesis imperfecta; the loss of TRIC-B impairs bone matrix synthesis due to compromised Ca2+ store functions in osteoblasts. On the other hand, MG56-knockout mice develop morphological abnormalities in the muscle SR and die during lactation stages due to suckling failure.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (12 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (3 results)

  • [Int'l Joint Research] University of Oxford(United Kingdom)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.2017

    • Author(s)
      El-Ajouz S, Venturi E, Witschas K, Beech M, Wilson AD, Lindsay C, Eberhardt D, O'Brien F, Iida T, Nishi M, Takeshima H, Sitsapesan R.
    • Journal Title

      J Physiol.

      Volume: 595 Issue: 14 Pages: 4769-4784

    • DOI

      10.1113/jp273550

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] <i><b>Gm7325</b></i><b> is MyoD-dependently expressed in activated muscle satellite </b><b>cells </b>2017

    • Author(s)
      Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.
    • Journal Title

      Biomedical Research

      Volume: 38 Issue: 3 Pages: 215-219

    • DOI

      10.2220/biomedres.38.215

    • NAID

      130006865614

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.2016

    • Author(s)
      C.Zhao, A.Ichimura, N.Qian, T.Iida, D.Yamazaki, N.Noma, M.Asagiri, K.Yamamoto, S.Komazaki, C.Sato, F.Aoyama, A.Sawaguchi, S.Kakizawa, M.Nishi, and H.Takeshima.
    • Journal Title

      science signaling

      Volume: 9 Issue: 428

    • DOI

      10.1126/scisignal.aad9055

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Positive regulation of the enzymatic activity of gastric H+,K+-ATPase by sialylation of its β-subunit.2016

    • Author(s)
      Fujii T, Watanabe M, Shimizu T, Takeshima H, Kushiro K, Takai M, Sakai H.
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1858 Issue: 6 Pages: 1228-1235

    • DOI

      10.1016/j.bbamem.2016.02.029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.2016

    • Author(s)
      Pigoni, M., Johanna Wanngren, J., Kuhn, J-H., Munro, K. M., Jenny M. Gunnersen, J. M., Takeshima, H., Feederle, R., Voytyuk, I., Strooper, B. D., Levasseur, M. D., Hrupka, B. J., Stephan, A., M&uuml;ller, S. A. & Lichtenthaler, S. F.
    • Journal Title

      Mol. Neurodegener.

      Volume: 11 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s13024-016-0134-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ca2+ microdomains organized by junctophilins2015

    • Author(s)
      Takeshima, H., Hoshijima, M. & Song, L-S.
    • Journal Title

      Cell Calcium

      Volume: 58 Issue: 4 Pages: 349-356

    • DOI

      10.1016/j.ceca.2015.01.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.2015

    • Author(s)
      Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
    • Journal Title

      FEBS Lett.

      Volume: in press Issue: 10 Pages: 1095-1104

    • DOI

      10.1016/j.febslet.2015.03.028

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Intracellular TRIC channels: electrophysiological and pathophysiological characterization.2017

    • Author(s)
      Takeshima H.
    • Organizer
      Gordon Research Conference; Organellar channels & transporters
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 所属研究室ページ

    • URL

      http://www.pharm.kyoto-u.ac.jp/biochem/member.htm

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室ページ

    • URL

      http://www.pharm.kyoto-u.ac.jp/biochem/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.pharm.kyoto-u.ac.jp/biochem/

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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