| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
We previously reported that higher exercise adherence is the key to increasing physical fitness and improving lifestyle-related diseases. Therefore, we determined independent factors affecting adherence by multiple-regression analysis. As a result, in addition to previously reported factors, V1a receptor polymorphisms were independent determinants of lower adherence. As for the mechanism of lower exercise adherence via V1a receptors, we found that central pressor responses at the onset of exercise were impaired in V1a receptor knockout mice, resulting in reduced motivated locomotion. Accordingly, in this study, we examined 1) whether V1a receptors played an important role at the onset of exercise in humans, and 2) whether exercise training + supplementation improved central pressor responses.
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