Developmental mechanisms of circadian clock in mouse embryo
| Project/Area Number |
15H04683
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAGITA Kazuhiro 京都府立医科大学, 医学(系)研究科(研究院), 教授 (90324920)
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| Co-Investigator(Renkei-kenkyūsha) |
KOIKE Nobuya 京都府立医科大学, 医学研究科, 講師 (00399685)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 環境生理学 / 生物時計 / 発生発達 / 概日リズム / 体内時計 / 発生 |
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| Outline of Final Research Achievements |
Circadian clocks reside in each cell-level throughout the body in mammals. Intrinsic cellular circadian clocks develop cell-autonomously during the cellular differentiation process. However, mechanisms controlling the emergence of cellular circadian clock oscillation in vivo have not yet been fully understood. Here, we show that Dicer/Dgcr8-mediated post-transcriptional mechanisms control the CLOCK protein expression in both mouse fetal hearts and in vitro differentiating ESCs, which contributes to the emergence of circadian clock in mammalian cells. This event occurs after cell lineage determination into hearts or loss of pluripotent stem cell markers in differentiating ESCs, suggesting the cellular differentiation-coupled clock development may be conducted by a two-step program consisting of cellular differentiation and following establishment of circadian transcriptional / translational feedback loops.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells2015
Author(s)
Toshihiro Hosokawa, Yoshiki Tsuchiya, Naoki Okubo, Tatsuya Kunimoto, Yoichi Minami, Hiroyoshi Fujiwara, Yasuhiro Umemura, Nobuya Koike, Toshikazu Kubo, Kazuhiro Yagita
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Journal Title
ACTA HISTOCHEMICA ET CYTOCHEMICA
Volume: 48
Issue: 6
Pages: 165-171
DOI
NAID
ISSN
0044-5991, 1347-5800
Related Report
Peer Reviewed / Open Access
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[Journal Article] C-H Activation Generates Period-Shortening Moleculaes That Target Cryptochrome in the Mammalian Circadian Clock.2015
Author(s)
Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Okawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irie S, Kay SA, Yoshimura T, Itami K.
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Journal Title
Angew Chem Int Ed
Volume: 54
Issue: 24
Pages: 7193-7197
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Disruption of circadian clockwork in in vivo reprogramming induced mouse kidney cancer and human Wilms Tumor.2017
Author(s)
Ohashi M, Umemura Y, Minami T, Watanabe H, Tanaka T, Miki T, Ukimura O, Tajiri T, Kondoh G, Yamada Y, Yagita K.
Organizer
2017 AACR ANNUAL MEETING, (Minisymposium),（Selected symposist）
Related Report
Int'l Joint Research
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[Presentation] 運動器の時間生物学2015
Author(s)
八木田和弘
Organizer
第７回京都南部整形外科病診連携の会
Place of Presentation
京都
Year and Date
2015-06-13
Related Report
Invited
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