Regulation of cellular metabolism and functions mediated by amino acid transporters and the mechanisms of action of their inhibitors

• Project/Area Number: 15H04685
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Osaka University
• Principal Investigator: KANAI Yoshikatsu 大阪大学, 医学系研究科, 教授 (60204533)
• Co-Investigator(Kenkyū-buntansha): 永森 收志 大阪大学, 医学系研究科, 准教授 (90467572) ; 大垣 隆一 大阪大学, 医学系研究科, 助教 (20467525) ; 奥田 傑 大阪大学, 医学系研究科, 助教 (50511846) ; 中込 咲綾 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) (60423894)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: トランスポーター / 受容体 / シグナル伝達系 / 細胞代謝制御 / 抗腫瘍薬 / がん / アミノ酸トランスポーター / リン酸化プロテオミクス / 腫瘍血管新生 / チャネル / 輸送系 / シグナル情報伝達系 / 輸送体介在シグナル / 代謝制御・細胞機能制御

Outline of Final Research Achievements

Amino acid transporter LAT1 (L-type amino acid transporter 1) is highly upregulated in various types of cancer. LAT1 is known to supply cancer cells with most of the essential amino acids, thereby supporting the rapid cell growth and proliferation. By using newly developed LAT1-selective inhibitor, we tried to understand the functions of amino acids as signaling molecules, and to reveal the cellular metabolisms and other cellular functions regulated by amino acids transported by LAT1, especially leucine. Phosphoproteomics analysis revealed amino acid signaling in the downstream of LAT1. We also demonstrated relationships between LAT1 with tumor angiogenesis and metastasis. This research revealed novel functional aspects of the amino acid transporter and amino acid signaling. The results obtained also contributed to the comprehensive understanding of the mechanisms of action of LAT1 inhibitors as a novel class of anti-cancer agents.

Research Products

• [Int'l Joint Research] University of Colorado(アメリカ)
• [Int'l Joint Research] Chosun University/Chonnam National University(韓国)
• [Int'l Joint Research] コロンビア医科大学院(アメリカ)
• [Int'l Joint Research] University of Barcelona(Spain)
• [Int'l Joint Research] University of Texas/University of Colorado(USA)
• [Journal Article] Relationship between LAT1 expression and resistance to chemotherapy in pancreatic ductal adenocarcinoma. (2018)
  • Author(s): Altan B, Kaira K, Watanabe A, Kubo N, Bao P, Dolgormaa G, Bilguun EO, Araki K, Kanai Y, Yokobori T, Oyama T, Nishiyama M, Kuwano H, Shirabe K
  • Journal Title: Cancer chemotherapy and pharmacology Volume: 81 Pages: 141-153
  • DOI: 10.1007/s00280-017-3477-4
  • Peer Reviewed
• [Journal Article] Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex. (2018)
  • Author(s): Liang Weng , Yi-Peng Han, Atsushi Enomoto, Yasuyuki Kitaura, Shushi Nagamori, Yoshikatsu Kanai, Naoya Asai, Jian An, Maki Takagishi, Masato Asai, Shinji Mii, Takashi Masuko, Yoshiharu Shimomura, Masahide Takahashi.
  • Journal Title: PLoS Biol. Volume: 16
  • DOI: 10.1371/journal.pbio.2005090
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans (2017)
  • Author(s): Masuo Y, Nagamori S, Hasegawa A, Hayashi K, Isozumi N, Nakamichi N, Kanai Y, Kato Y.
  • Journal Title: Pharmaceutical research Volume: 印刷中 Pages: 1233-1243
  • DOI: 10.1007/s11095-017-2140-4
  • NAID: 120006306246
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma. (2017)
  • Author(s): Kume E, Mutou T, Kansaku N, Takahashi H, Wempe MF, Ikegami M, Kanai Y, Endou H, Wakui S.
  • Journal Title: Microscopy (Oxford, England) Volume: 24 Pages: 198-203
  • DOI: 10.1093/jmicro/dfx008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. (2017)
  • Author(s): Ohgaki R, Ohmori T, Hara S, Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y.
  • Journal Title: Molecular and cellular biology Volume: 印刷中
  • DOI: 10.1128/mcb.00427-16
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma. (2017)
  • Author(s): Honjo H, Toh Y, Sohda M, Suzuki S, Kaira K, Kanai Y, Nagamori S, Oyama T, Yokobori T, Miyazaki T, Kuwano H
  • Journal Title: Anticancer Research Volume: 37 Pages: 4147-4155
  • DOI: 10.21873/anticanres.11802
  • Peer Reviewed
• [Journal Article] JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. (2017)
  • Author(s): Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H, Kim JK
  • Journal Title: The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology Volume: 21 Pages: 599-607
  • DOI: 10.4196/kjpp.2017.21.6.599
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells (2017)
  • Author(s): Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
  • Journal Title: Cell reports Volume: 21 Pages: 1824-1838
  • DOI: 10.1016/j.celrep.2017.10.082
  • Peer Reviewed / Open Access
• [Journal Article] Ratiometric fluorescence imaging of cell surface pH by poly(ethylene glycol)-phospholipid conjugated with fluorescein isothiocyanate. (2017)
  • Author(s): Ryuichi Ohgaki, Yuji Teramura, Daichi Hayashi, Suguru Okuda, Shushi Nagamori, Madoka Taka and Yoshikatsu Kanai
  • Journal Title: Scientific Reports Volume: 7 Pages: 17484-17484
  • DOI: 10.1038/s41598-017-17459-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease. (2017)
  • Author(s): Shinozaki Yasuyuki、Furuichi Kengo、Toyama Tadashi、Kitajima Shinji、Hara Akinori、Iwata Yasunori、Sakai Norihiko、Shimizu Miho、Kaneko Shuichi、Isozumi Noriyoshi、Nagamori Shushi、Kanai Yoshikatsu、Sugiura Tomoko、Kato Yukio、Wada Takashi
  • Journal Title: Kidney Int. Volume: 92 Pages: 1356-1369
  • DOI: 10.1016/j.kint.2017.04.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET. (2017)
  • Author(s): Watabe T, Ikeda H, Nagamori S, Wiriyasermkul P, Tanaka Y, Naka S, Kanai Y, Hagiwara K, Aoki M, Shimosegawa E, Kanai Y, Hatazawa J.
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 44 Pages: 321-331
  • DOI: 10.1007/s00259-016-3487-1
  • Peer Reviewed
• [Journal Article] Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue: In vivo Metabolic Turnover Analysis. (2017)
  • Author(s): Nagao H, Nishizawa H, Bamba T, Nakayama Y, Isozumi N, Nagamori S, Kanai Y, Tanaka Y, Kita S, Fukuda S, Funahashi T, Maeda N, Fukusaki E, Shimomura I.
  • Journal Title: J Biol Chem. Volume: 292 Pages: 4469-4483
  • DOI: 10.1074/jbc.m116.770172
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer. (2017)
  • Author(s): Satoh T, Kaira K, Takahashi K, Takahashi N, Kanai Y, Asao T, Horiguchi J, Oyama T.
  • Journal Title: Anticancer Res. Volume: 37 Pages: 631-636
  • Peer Reviewed
• [Journal Article] Structure-activity relationship of a novel series of inhibitors for cancer type transporter L-type amino acid transporter 1 (LAT1) (2017)
  • Author(s): Kongpracha P, Nagamori S, Wiriyasermkul P, Tanaka Y, Kaneda K, Okuda S, Ohgaki R, Kanai Y.
  • Journal Title: J Pharmacol Sci Volume: 133 Pages: 96-102
  • DOI: 10.1016/j.jphs.2017.01.006
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer (2017)
  • Author(s): Ohshima K, Nojima S, Tahara S, Kurashige M, Hori Y, Hagiwara K, Okuzaki D, Oki S, Wada N, Ikeda JI, Kanai Y, Morii E.
  • Journal Title: Sci Rep. Volume: 7 Pages: 45504-45504
  • DOI: 10.1038/srep45504
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2. (2016)
  • Author(s): Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T.
  • Journal Title: Clin Sci (Lond). Volume: 130 Pages: 499-512
  • DOI: 10.1042/cs20150554
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Upregulation of LAT1 during anti-androgen therapy contribute to progression in prostate cancer cells. (2016)
  • Author(s): Xu M, Sakamoto S, Matsushima J, Kimura T, Ueda T, Mizokami A, Kanai Y, Ichikawa T.
  • Journal Title: J Urol. Volume: 195 Pages: 1588-1597
  • DOI: 10.1016/j.juro.2015.11.071
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuda S, Kojima N, Hari Y, Kiyonaka S, Mori Y, Tominaga H, Ohgaki R, Kanai Y.
  • Journal Title: Amino Acids Volume: 48 Pages: 1045-1058
  • DOI: 10.1007/s00726-015-2158-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Interaction of the Sodium/Glucose Cotransporter (SGLT) 2 inhibitor Canagliflozin with SGLT1 and SGLT2. (2016)
  • Author(s): Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Shiotani M, Nagamori S, Kanai Y.
  • Journal Title: J Pharmacol Exp Ther. Volume: 358 Pages: 94-102
  • DOI: 10.1124/jpet.116.232025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Core-fucosylation plays a pivotal role in hepatitis B pseudo virus infection: a possible implication for HBV glycotherapy (2016)
  • Author(s): Takamatsu S, Shimomura M, Kamada Y, Maeda H, Sobajima T, Hikita H, Iijima M, Okamoto Y, Misaki R, Fujiyama K, Nagamori S, Kanai Y, Takehara T, Ueda K, Kuroda S, Miyoshi E.
  • Journal Title: Glycobiology Volume: 26 Pages: 1180-1189
  • DOI: 10.1093/glycob/cww067
  • Peer Reviewed
• [Journal Article] Efficacy of LAT1 inhibition as a therapeutic target in esophageal squamous cell carcinoma (2016)
  • Author(s): Ohshima Y, Kaira K, Yamaguchi A, Oriuchi N, Tominaga H, Nagamori S, Kanai Y, Yokobori T, Miyazaki T, Asao T, Tsushima Y, Kuwano H, Ishioka NS.
  • Journal Title: Cancer Science Volume: 107 Pages: 1499-1505
  • DOI: 10.1111/cas.13021
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of a human NPT1/SLC17A1 missense variant which increases urate export. (2016)
  • Author(s): Sakiyama M, Matsuo H, Nagamori S, Ling W, Kawamura Y, Nakayama A, Higashino T, Chiba T, Ichida K, Kanai Y, Shinomiya N.
  • Journal Title: Nucleosides Nucleotides Nucleic Acids. Volume: 35 Pages: 536-542
  • Peer Reviewed
• [Journal Article] Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder. (2016)
  • Author(s): Tarlungeanu DC, Deliu E, Dotter CP, Kara M, Janiesch PC, Scalise M, Galluccio M, Tesulov M, Morelli E, Sonmez FM, Bilguvar K, Ohgaki R, Kanai Y, Johansen A, Esharif S, Ben-Omran T, Topcu M, Schlessinger A, Indiveri C, Duncan KE, Caglayan AO, Gunel M, Gleeson JG, Novarino G.
  • Journal Title: Cell. Volume: 167 Pages: 1481-1494
  • DOI: 10.1016/j.cell.2016.11.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1 (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M, Kanai Y.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 113 Pages: 775-780
  • DOI: 10.1073/pnas.1519959113
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging (2016)
  • Author(s): Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Oriuchi N, Nagamori S, Kanai Y.
  • Journal Title: Cancer Sci Volume: 107 Pages: 347-352
  • DOI: 10.1111/cas.12878
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Transport of 3-fluoro-l-α-methyl-tyrosine (FAMT) by organic ion transporters explains renal background in [18F] FAMT positron emission tomography. (2016)
  • Author(s): Wei L, Tominaga H, Ohgaki R, Wiriyasermkul P, Hagiwara K, Okuda S, Kaira K, Kato Y, Oriuchi N, Nagamori S, Kanai Y.
  • Journal Title: J Pharmacol Sci Volume: 130 Pages: 101-109
  • DOI: 10.1016/j.jphs.2016.01.001
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinicopathological significance of LAT1 and ASCT2 in patients with surgically resected esophageal squamous cell carcinoma. (2016)
  • Author(s): Honjo H, Kaira K, Miyazaki T, Yokobori T, Kanai Y, Nagamori S, Oyama T, Asao T, Kuwano H.
  • Journal Title: J Surg Oncol. Volume: 113 Pages: 381-9
  • DOI: 10.1002/jso.24160
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SGLT2阻害薬の特徴：基礎研究の観点から (2016)
  • Author(s): 金井 好克
  • Journal Title: Progress in Medicine Volume: 36 Pages: 183-188
• [Journal Article] CD98 is a novel prognostic indicator for patients with stage III/IV hypopharyngeal squamous cell carcinoma. (2015)
  • Author(s): Toyoda M, Kaira K, Shino M, Sakakura K, Takahashi K, Takayasu Y, Tominaga H, Oriuchi N, Nikkuni O, Suzuki M, Iijima M, Tsukamoto N, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
  • Journal Title: Head Neck Volume: in press Pages: 1569-1574
  • DOI: 10.1002/hed.23797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of a Widely Usable Amino Acid Tracer: ⁷⁶Br-α-Methyl-Phenylalanine for Tumor PET Imaging. (2015)
  • Author(s): Hanaoka H, Ohshima Y, Suzuki Y, Yamaguchi A, Watanabe S, Uehara T, Nagamori S, Kanai Y, Ishioka NS, Tsushima Y, Endo K, Arano Y.
  • Journal Title: J Nucl Med. Volume: 56 Pages: 791-7
  • DOI: 10.2967/jnumed.114.152215
  • Peer Reviewed
• [Journal Article] Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage III/IV Laryngeal Squamous Cell Carcinoma. (2015)
  • Author(s): Nikkuni O, Kaira K, Toyoda M, Shino M, Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K.
  • Journal Title: Pathol Oncol Res. Volume: 21 Pages: 1175-1181
  • DOI: 10.1007/s12253-015-9954-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular architecture of the stria vascularis membrane transport system, which is essential for physiological functions of the mammalian cochlea (2015)
  • Author(s): Uetsuka S, Ogata G, Nagamori S, Isozumi N, Nin F, Yoshida T, Komune S, Kitahara T, Kikkawa Y, Inohara H, Kanai Y, Hibino H.
  • Journal Title: Eur J Neurosci Volume: 42 Pages: 1984-2002
  • DOI: 10.1111/ejn.12973
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] L-type amino acid transporter-1 and CD98 expression in bone and soft tissue tumors. (2015)
  • Author(s): Koshi H, Sano T, Handa T, Yanagawa T, Saitou K, Nagamori S, Kanai Y, Takagishi K, Oyama T.
  • Journal Title: Pathol Int. Volume: 65 Pages: 460-467
  • DOI: 10.1111/pin.12323
  • Peer Reviewed
• [Journal Article] Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. (2015)
  • Author(s): Rosario FJ, Kanai Y, Powell TL, Jansson T.
  • Journal Title: Obesity (Silver Spring). Volume: 23 Pages: 1663-1670
  • DOI: 10.1002/oby.21165
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) expression in cutaneous melanoma. (2015)
  • Author(s): Shimizu A, Kaira K, Kato M, Yasuda M, Takahashi A, Tominaga H, Oriuchi N, Nagamori S, Kanai Y, Oyama T, Asao T, Ishikawa O.
  • Journal Title: Melanoma Res Volume: 25 Pages: 399-405
  • DOI: 10.1097/cmr.0000000000000181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. (2015)
  • Author(s): Furukawa J, Inoue K, Maeda J, Yasujima T, Ohta K, Kanai Y, Takada T, Matsuo H, Yuasa H
  • Journal Title: Sci Rep. Volume: 5 Pages: 15057-15057
  • DOI: 10.1038/srep15057
  • Peer Reviewed / Open Access
• [Journal Article] 疾患起因性変異ノックインマウスを用いた日本人型シスチン尿症変異の特性解析 (2015)
  • Author(s): 永森 收志, 河本 泰治, Wiriyasermkul Pattama, 中込 咲綾, 金井 好克
  • Journal Title: 日本尿路結石症学会誌 Volume: 14 Pages: 151-153
• [Presentation] アミノ酸トランスポーターを標的としたがん細胞代謝制御と治療 (2018)
  • Author(s): 金井 好克
  • Organizer: 日本学術会議薬学委員会生物系薬学分科会、日本薬学会主催シンポジウム「がんと代謝」～新たな研究領域の創生から革新的な治療薬開発へ～
  • Invited
• [Presentation] 腫瘍血管新生に寄与する血管内皮細胞のアミノ酸トランスポーター (2018)
  • Author(s): 大垣隆一、Quan Lili、奥田傑、永森收志、金井好克
  • Organizer: 第1回 がんと代謝研究会・若手の会
• [Presentation] SGLT2阻害薬の作用メカニズムとトランスポーター標的薬による代謝制御 (2018)
  • Author(s): 金井 好克
  • Organizer: 名古屋内科医会共催講演会
  • Invited
• [Presentation] トランスポーターから見た尿酸の最近の動向 (2018)
  • Author(s): 金井 好克
  • Organizer: 北陸高尿酸血症セミナー
  • Invited
• [Presentation] Cancer therapeutics and diagnosis targeting amino acid transporters: From pharmacological aspects (2018)
  • Author(s): 金井 好克
  • Organizer: Campus Asia Program Faculty meeting, Symopsium and Workshop
  • Int'l Joint Research / Invited
• [Presentation] Construction of Flp-in 3T3 cell line stably express mLAT1 fused with AcGFP (2018)
  • Author(s): Hanbing Liu, Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Yoshikatsu Kanai
  • Organizer: Campus Asia Program Faculty meeting, Symopsium and Workshop
  • Int'l Joint Research
• [Presentation] Effect of five amino acids stimulation on mTORC1 signaling pathway in HEK293T cells (2018)
  • Author(s): Xuhao Huang, Chunhuan Jin, Ryuichi Ohgaki, Suguru Okuda, Yoshikatsu Kanai
  • Organizer: Campus Asia Program Faculty meeting, Symopsium and Workshop
  • Int'l Joint Research
• [Presentation] Structure-activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes (2018)
  • Author(s): Chunhuan Jin,Ling Wei, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: Campus Asia Program Faculty meeting, Symopsium and Workshop
  • Int'l Joint Research
• [Presentation] BPA-dipeptides, novel boron delivery agents for boron neutron capture therapy, targeting the oligopeptide transporters (2018)
  • Author(s): Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Suguru Okuda, Shushi Nagamori, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai
  • Organizer: 大阪大学医学系研究フォーラム 第10回若手研究フォーラム
• [Presentation] 栄養食品成分の吸収・排出を担う膜輸送体の網羅的定量プロテオミクスによる変動解析Comprehensive proteomics reveals alteration of membrane transport proteins responsible for absorption and excretion of nutrients and food ingredients. (2017)
  • Author(s): 永森收志
  • Organizer: 2017年度 日本農芸化学会年会 シンポジウム「栄養食品成分の吸収と排出～膜を超える仕組み」
  • Place of Presentation: 京都
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] SGLT2阻害薬カナグリフロジンのヒトSGLT1およびSGLT2に対する作用キネティクスと阻害メカニズムの検討 (2017)
  • Author(s): 大垣隆一、Ling Wei、山田和徳、原大樹、栗山千亜紀、奥田傑、植田喜一郎、Laurent Leclercq、Rao N.V.S. Mamidi、塩谷正治、永森收志、金井好克
  • Organizer: 第90回 日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-14
• [Presentation] アミノ酸トランスポーターLAT1によるロイシン誘導体の認識とmTORC1シグナル活性化の関係 (2017)
  • Author(s): 奥田傑、Pattama Wiriyasermkul、大垣隆一、永森收志、金井好克
  • Organizer: 第90回 日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-14
• [Presentation] 有機アニオントランスポーターOAT1に対する芳香族アミノ酸誘導体の構造活性相関：イメージングプローブの腎臓におけるバックグラウンド集積を誘起する分子内構造の同定 (2017)
  • Author(s): 魏玲、大垣隆一、富永英之、兼田加珠子、奥田傑、永森收志、金井好克
  • Organizer: 第90回 日本薬理学会年会
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-14
• [Presentation] 腫瘍細胞型アミノ酸トランスポーターリガンドの構造活性相関から見えてくる創薬標的としての意義 (2017)
  • Author(s): 金井 好克
  • Organizer: 第90回日本薬理学会年会シンポジウム「トランスポーターの分子同定から展開する創薬研究」
  • Place of Presentation: 長崎
  • Year and Date: 2017-03-14
  • Invited
• [Presentation] Amino acid transporter LAT1 as a novel molecular target for cancer diagnosis and therapeutics (2017)
  • Author(s): Yoshikatsu Kanai
  • Organizer: AMED-ALBERTA WORKSHOP FOR MEDICAL INNOVATION
  • Place of Presentation: Calgary, Alberta, Canada
  • Year and Date: 2017-02-24
  • Int'l Joint Research / Invited
• [Presentation] SGLT2阻害薬カナグリフロジンによる腎刷子縁膜タンパク質の発現変動の網羅的定量プロテオミクスを用いた解析 (2017)
  • Author(s): 永森收志、齊藤隆太、五十棲規嘉、栗山千亜紀、塩谷正治、大垣隆一、奥田傑、 金井好克
  • Organizer: 第60回 日本糖尿病学会年次学術集会
• [Presentation] SGLT2阻害薬の作用メカニズムと新たな糖尿病治療薬としての期待 (2017)
  • Author(s): 金井 好克
  • Organizer: 講演会 糖尿病治療の最前線
  • Invited
• [Presentation] Transporter researches in medical and pharmaceutical sciences in particular focusing on molecular target drug discovery. (2017)
  • Author(s): 金井 好克
  • Organizer: 天津中医薬大学特別講演会
  • Int'l Joint Research / Invited
• [Presentation] がんのアミノ酸代謝特性を標的にした治療法の開発 (2017)
  • Author(s): 金井 好克
  • Organizer: 次世代がん医療創生研究事業領域Ａ会議
  • Invited
• [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter retains substrate binding but diminishes the transport activity. (2017)
  • Author(s): Nagamori S, Kawamoto Y, Wiriyasermkul P, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: Gordon Research Conference: Mechanisms of Membrane Transport
  • Int'l Joint Research
• [Presentation] Structure-activity relationship of novel inhibitors for cancer type amino acid transporter LAT1 (2017)
  • Author(s): Pornparn Kongpracha, Pattama Wiriyasermkul,Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第131回 日本薬理学会近畿部会
• [Presentation] アミノ酸トランスポーターLAT1は膜融合関連因子4F2hcの細胞膜提示による胎盤合胞体性栄養膜の形成に必須である (2017)
  • Author(s): 大垣隆一、大森崇弘、原早織、中込咲綾、金井正美、兼田（中島）加珠子、奥田傑、永森收志、金井好克
  • Organizer: 第12回 トランスポーター研究会
• [Presentation] がん細胞のアミノ酸トランスポーター抑制薬による抗腫瘍効果 (2017)
  • Author(s): 金井 好克
  • Organizer: 第5回 がんと代謝研究会
  • Invited
• [Presentation] Phosphoproteomics reveals the cellular processes affected by leucine transported through LAT1, a cancer type amino acid transporter (2017)
  • Author(s): Pornparn Kongpracha, Pattama Wiriyasermkul, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 日本プロテオーム学会2017年大会 JHUPO 第15回大会
• [Presentation] がん細胞特異的アミノ酸トランスポーターLAT1選択的PETプローブの開発 (2017)
  • Author(s): 永森 收志、渡部 直史、金井 泰和、仲 定宏、下瀬川 恵久、畑澤 順、金井 好克
  • Organizer: 第13回 小動物インビボイメージング研究会
• [Presentation] がん細胞型アミノ酸トランスポーターLAT1の発現と基質認識の特徴 (2017)
  • Author(s): 金井 好克
  • Organizer: 第8回BNCTなかもずセミナー
  • Invited
• [Presentation] 低分子創薬と大学発ベンチャー (2017)
  • Author(s): 金井 好克
  • Organizer: PMDA（医薬品医療機器総合機構）科学委員会
  • Invited
• [Presentation] Development of anti-tumor drugs and PET probes targeting amino acid transporters in cancers (2017)
  • Author(s): 金井 好克
  • Organizer: BioMedical Transporters 2017 Conference
  • Int'l Joint Research / Invited
• [Presentation] SGLT2阻害薬の最近の話題とトランポーターを標的とした創薬の試み (2017)
  • Author(s): 金井 好克
  • Organizer: 第７９回徳島大学糖尿病臨床・研究開発センター講演会
  • Invited
• [Presentation] Structure-activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes (2017)
  • Author(s): Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 大阪大学医学系研究フォーラム 第9回若手研究フォーラム
• [Presentation] Non-competitive LAT1 inhibitors suppress mTORC1 signaling similary to competitive LAT1 inhibitors (2017)
  • Author(s): Pornparn Kongpracha, Suguru Okuda, Ryuichi Ohgaki, Yoshikatsu Kanai, Shushi Nagamori
  • Organizer: 第132回 日本薬理学会近畿部会
• [Presentation] LAT1 in endothelial cells as a novel target of anti-angiogenic cancer therapy (2017)
  • Author(s): Lili Quan, Ryuichi Ohgaki, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第132回 日本薬理学会近畿部会
• [Presentation] Critical moieties of aromatic amino acid for renal accumulation of tumor imaging probes (2017)
  • Author(s): Chunhuan Jin, Ling Wei, Ryuichi Ohgaki, Hideyuki Tominaga, Suguru Okuda, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第132回 日本薬理学会近畿部会
• [Presentation] 短寿α線核種を利用したがん治療プローブの開発 (2017)
  • Author(s): 兼田加珠子、張子見、真鍋良幸、下山敦史、樺山一哉、渡部直史、豊嶋厚史、畑澤順、金井好克、吉村崇、深瀬浩一、篠原厚
  • Organizer: 第132回 日本薬理学会近畿部会
• [Presentation] 膜輸送複合体の機能的再構成人工膜－生体界面研究のモデル系を目指して (2017)
  • Author(s): 永森收志
  • Organizer: 第6回 生体界面研究会
  • Place of Presentation: 金沢
• [Presentation] がん細胞型アミノ酸トランスポーターを標的とした新規作用機序の抗悪性腫瘍薬と汎用性の高いがん特異的PETプロープの開発 (2017)
  • Author(s): 金井 好克
  • Organizer: 平成28年度創薬シーズ事業化コンペティション
  • Place of Presentation: 大阪
• [Presentation] Pharmacology to innovative drug development: cancer therapeutics and diagnosis targeting amino acid transporters (2017)
  • Author(s): Yoshikatsu Kanai
  • Organizer: Campus Asia International Symposium (Ⅱ)
  • Place of Presentation: 大阪
  • Int'l Joint Research / Invited
• [Presentation] アミノ酸トランスポーターLAT1は胎盤合胞体性栄養膜の形成に必須である：膜融合関連因子4F2hcの細胞膜提示による細胞融合への寄与 (2016)
  • Author(s): 大垣 隆一、大森 崇弘、原 早織、中込 咲綾、金井 正美、兼田 加珠子、奥田 傑、永森 收志、金井 好克
  • Organizer: 第39回 日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-11-30
• [Presentation] 腎近位尿細管に残されていた第二のシスチントランスポーターはシスチン尿症関連タンパク質rBATの未知なる結合相手だった (2016)
  • Author(s): 永森收志
  • Organizer: 第89回日本生化学会大会、シンポジウム「膜輸送体学の「温故知新」～長年の謎の解明をめざして」
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] Transporter and urolithiasis (2016)
  • Author(s): Yoshikatsu Kanai
  • Organizer: 13th International Symposium on Urolithiasis
  • Place of Presentation: 千葉
  • Year and Date: 2016-07-19
  • Int'l Joint Research / Invited
• [Presentation] Significance of the comprehensive and quantitative proteomics of membrane transport proteins in drug discovery and in silico modeling. (2016)
  • Author(s): Shushi Nagamori
  • Organizer: International and Interdisciplinary Symposium 2016“Towards a New Era of Cardiovascular Research”
  • Place of Presentation: 東京
  • Year and Date: 2016-07-12
  • Int'l Joint Research / Invited
• [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features (2016)
  • Author(s): Ling Wei, Ryuichi Ohgaki, Kazunori Yamada, Taiki Hara, Chiaki Kuriyama, Suguru Okuda, Kiichiro Ueta, Masaharu shiotani, Shushi Nagamori and Yoshikatsu Kanai
  • Organizer: International and Interdisciplinary Symposium 2016 “Towards a New Era of Cardiovascular Research”
  • Place of Presentation: 東京
  • Year and Date: 2016-07-12
  • Int'l Joint Research
• [Presentation] Inhibition kinetics, sidedness of action, and transporter-mediated uptake of the sodium/glucose cotransporter (SGLT) 2 inhibitor canagliflozin: implications for its pharmacodynamic and pharmacokinetic features (2016)
  • Author(s): Ohgaki R, Wei L, Yamada K, Hara T, Kuriyama C, Okuda S, Ueta K, Leclercq L, Mamidi RN, Shiotani M, Nagamori S, Kanai Y
  • Organizer: 76th American Diabetes Association Scientific Sessionｓ
  • Place of Presentation: New Orleans, Louisiana, US
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: The Kaback Symposium
  • Place of Presentation: Bethesda, Maryland, US
  • Year and Date: 2016-06-09
  • Int'l Joint Research / Invited
• [Presentation] Novel Cystine Transporter in Renal Proximal Tubule Identied as a “Missing Partner” of Cystinuria-Related Membrane Protein rBAT/SLC3A1. (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Kanai Y.
  • Organizer: Experimental Biology 2016
  • Place of Presentation: San Diego, CA, US
  • Year and Date: 2016-04-01
  • Int'l Joint Research
• [Presentation] SGLT2阻害薬が再認識させた腎尿細管トランスポーターの創薬標的としての意義 (2016)
  • Author(s): 金井好克
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
  • Invited
• [Presentation] Significance of comprehensive and quantitative proteomics of membrane transport proteins in drug discovery. 創薬研究における膜輸送体の網羅的解析と定量解析の意義 (2016)
  • Author(s): Nagamori S
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
  • Invited
• [Presentation] Interaction of potential hepatotoxic ingredients of Traditional Chinese Medicine with liver drug transporters OATP1B1 and MDR1 (2016)
  • Author(s): Lili Quan，Zijie Song, Yueqing Zhou, Ryuichi Ohgaki, Shushi Nagamori, Xin He, Yoshikatsu Kanai
  • Organizer: 第63回 日本生化学会 近畿支部例会学会
  • Place of Presentation: 神戸
• [Presentation] Interaction of halogenated aromatic amino acid probes for tumor imaging with renal organic anion transporter OAT1: the mechanisms of renal accumulation of the imaging probes (2016)
  • Author(s): Ling Wei、大垣 隆一、富永 英之、Quan Lili、兼田（中島）加珠子、奥田 傑、永森 收志、金井 好克
  • Organizer: 第129回 日本薬理学会近畿部会
  • Place of Presentation: 広島
• [Presentation] 栄養素トランスポーターを標的とした病態代謝制御：SGLT2阻害薬の最近の知見とアミノ酸・有機酸トランスポーターの創薬標的としての可能性 (2016)
  • Author(s): 金井 好克
  • Organizer: 第164回 分泌セミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] トランスポーターを標的とした創薬 (2016)
  • Author(s): 金井 好克
  • Organizer: 千里ライフサイエンスセミナーK2「トランスポーターと創薬：構造と病態からのアプローチ」
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Novel cystine transporter in renal proximal tubule identified as a “missing partner” of cystinuria-related membrane protein rBAT/SLC3A1 (2016)
  • Author(s): Nagamori S, Wiriyasermkul P, Espino Guarch M, Okuyama K, Nakagomi S, Okuda S, Ohgaki R, Palacin M, Kanai Y.
  • Organizer: 第26 回日本尿路結石症学会
  • Place of Presentation: 千葉
• [Presentation] Amino acid transporters as targets for cancer-selective drug delivery and anti-cancer therapeutics (2016)
  • Author(s): Yoshikatsu Kanai
  • Organizer: 2nd Drug Transporters Forum
  • Place of Presentation: Lanzhou, China
  • Int'l Joint Research / Invited
• [Presentation] がん細胞アミノ酸トランスポーターを標的としたがんの検出と細胞活性制御 (2016)
  • Author(s): 金井 好克
  • Organizer: 日本農芸化学会平成28 年度関西支部大会シンポジウム「アミノ酸研究の最前線」
  • Place of Presentation: 大津
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした創薬研究 (2016)
  • Author(s): 永森收志
  • Organizer: 第一回名古屋大学医薬系3部局交流シンポジウム ～生物学から創薬への展開～
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] アミノ酸トランスポーターLAT1による基質認識とmTORC1シグナル活性化に必要なロイシンの構造部位の決定 (2016)
  • Author(s): 奥田 傑, Pattama Wiriyasermkul, 大垣 隆一, 永森 收志, 金井 好克
  • Organizer: 第130回 日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] アミノ酸トランスポーターLAT1阻害によるがん転移抑制効果の検討 (2016)
  • Author(s): 兼田 加珠子, 魏 玲, Pornparn Kongpracha, 大垣 隆一, 永森 收志, 金井 好克
  • Organizer: 第130回 日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] がん細胞のアミノ酸トランスポーターを標的としたがんPET 診断と抗腫瘍治療の開発 (2015)
  • Author(s): 金井好克
  • Organizer: 第2回臨床アミノ酸研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] Non-competitive inhibitors arrest the alternating-access mechanism of amino acid transporters. (2015)
  • Author(s): Nagamori S
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Leucine transported by a cancer-type amino acid transporter LAT1 affects multiple cellular processes in pancreatic cancer cells. (2015)
  • Author(s): Pornparn Kongpracha, Pattama Wiriyasermkul, Noriyoshi Isozumi, Kazuko Kaneda-Nakashima, Suguru Okuda, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] アミノ酸輸送体阻害薬は新規抗がん薬として有用である Inhibitor of amino acid transporter is useful as a novel anti-cancer drug (2015)
  • Author(s): 兼田（中島）加珠子、疋田隼人、Pornparn Kongpracha、Ling Wei、大垣隆一、永森收志、竹原徹郎、金井好克
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
• [Presentation] HEK293T細胞のアミノ酸シグナルによるmTORC1活性化の特性についての検討 Properties of mTORC1 regulation by amino acid signaling in HEK293T cells (2015)
  • Author(s): 大垣 隆一、永森 收志、ウィリヤサムクン パッタマ、萩原 浩平、金井 好克
  • Organizer: 第38回分子生物学会年会・第88回生化学会大会合同大会（BMB2015）
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Transporters in pharmacology and molecular target drug discovery (2015)
  • Author(s): 金井好克
  • Organizer: APSA-ASCEPT Joint Scientific Meeting 2015
  • Place of Presentation: Hobart, Australia
  • Year and Date: 2015-11-29
  • Int'l Joint Research / Invited
• [Presentation] SGLT2阻害薬の作用とメカニズム (2015)
  • Author(s): 金井好克
  • Organizer: 日本糖尿病合併症学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-11-27
  • Invited
• [Presentation] Na+/グルコース共輸送体2（SGLT2）阻害薬の作用キネティクスと阻害メカニズム (2015)
  • Author(s): 大垣 隆一、Wei Ling、永森 收志、山田 和徳、原 大樹、栗山 千亜紀、植田 喜一郎、塩谷 正治、金井 好克
  • Organizer: 第128回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2015-11-20
• [Presentation] アミノ酸トランスポーター阻害薬による抗腫瘍薬作用増強効果についての検討 (2015)
  • Author(s): 兼田加珠子、Pornparn Kongpracha、Ling Wei、大垣 隆一、 永森 收志、金井 好克
  • Organizer: 第37回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2015-11-19
• [Presentation] プロテオミクスによるアミノ酸輸送と介在シグナルの全体像の解明 (2015)
  • Author(s): 永森收志
  • Organizer: 日本アミノ酸学会第9回学術大会（JSAAS2015）
  • Place of Presentation: 滋賀
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] Investigation of regulation mechanisms of cancer specific amino acid transporter, LAT1 がん特異的アミノ酸トランスポーターLAT1の制御システムの探索 (2015)
  • Author(s): 兼田（中島）加珠子、永森 收志、 金井 好克
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 網羅的定量プロテオミクスと機能解析によるがん細胞株アミノ酸トランスポーターのプロファイリング (2015)
  • Author(s): 永森收志
  • Organizer: 平成27年度生理研研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2015-09-15
  • Invited
• [Presentation] 網羅的プロテオーム解析が捉えるアミノ酸トランスポーターによる生体システムの制御 (2015)
  • Author(s): 永森收志
  • Organizer: 平成27年（第96回）日本栄養・食糧学会関東支部大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] 疾患起因性変異ノックインマウスを用いた日本人型シスチン尿症変異の特性解析 (2015)
  • Author(s): 永森收志、 河本 泰治、Pattama Wiriyasermkul1、中込 咲綾、金井 好克
  • Organizer: 第25回日本尿路結石症学会
  • Place of Presentation: 旭川
  • Year and Date: 2015-08-28
• [Presentation] Amino acid transporters as targets for cancer-selective drug delivery and anti-cancer therapeutics (2015)
  • Author(s): 金井好克
  • Organizer: BioMedical Transporters Conference 2015
  • Place of Presentation: Lugano, Switzerland
  • Year and Date: 2015-08-09
  • Int'l Joint Research / Invited
• [Presentation] プロテオミクスと輸送機能測定によるがん細胞アミノ酸トランスポーターの網羅的解析 (2015)
  • Author(s): 永森收志、五十棲規義、Wiriyasermkul P、Kongpracha P、金井好克
  • Organizer: 日本プロテオーム学会2015年会
  • Place of Presentation: 熊本
  • Year and Date: 2015-07-23
• [Presentation] アミノ酸輸送体阻害薬による抗がん剤作用増強効果についての検討 (2015)
  • Author(s): 兼田 加珠子、Pornparn Kongpracha、Ling Wei、大垣 隆一、永森 收志、金井 好克
  • Organizer: 第24回日本Cell Death学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-11
• [Presentation] がん特異的アミノ酸トランスポーターを標的としたがん診断法と治療法の開発 (2015)
  • Author(s): 永森收志
  • Organizer: 第31回日本DDS学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-02
  • Invited
• [Presentation] Transport of 3-fluoro-L-α-methyl-tyrosine (FAMT) by organic ion transporters: a possible cause of renal background in 18F-FAMT PET (2015)
  • Author(s): Wei Ling、富永 英之、Wiriyasermkul Pattama、大垣 隆一、萩原浩平、奥田傑、永森 收志、金井 好克
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 岐阜
  • Year and Date: 2015-06-26
• [Presentation] アミノ酸トランスポーターとD-アミノ酸輸送 (2015)
  • Author(s): 永森收志、金井好克
  • Organizer: 第15回日本蛋白質科学会
  • Place of Presentation: 徳島
  • Year and Date: 2015-06-24
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした創薬研究 (2015)
  • Author(s): 永森收志、金井好克
  • Organizer: 第10回日本トランスポーター研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-06-21
  • Invited
• [Presentation] がん細胞のアミノ酸トランスポーターを標的としたがん診断と抗腫瘍薬の開発 (2015)
  • Author(s): 金井好克
  • Organizer: 第４回谷根千腎カンファレンス
  • Place of Presentation: 東京
  • Year and Date: 2015-06-16
  • Invited
• [Presentation] Metabolomics and proteomics of knockout mice reveal physiological function of an orphan organic anion transporter. (2015)
  • Author(s): Nagamori S
  • Organizer: The 3rd Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications”
  • Place of Presentation: 淡路島
  • Year and Date: 2015-06-14
  • Int'l Joint Research / Invited
• [Presentation] SGLT2阻害薬カナグリフロジンのヒトSGLT2による輸送と細胞内外からの阻害作用の検討 (2015)
  • Author(s): 大垣隆一、Ling Wei、永森收志、山田和徳、原大樹、栗山千亜紀、植田喜一郎、塩谷正治、金井好克
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21
• [Presentation] Inhibition of the LAT1-mediated leucine transport affects multiple cellular processes in pancreatic cancer cells. (2015)
  • Author(s): Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第62回日本生化学会近畿支部例会
  • Place of Presentation: 滋賀
  • Year and Date: 2015-05-16