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Non-canonical function of erythroid growth factor erythropoietin

Research Project

Project/Area Number 15H04691
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

Suzuki Norio  東北大学, 医学系研究科, 准教授 (20447254)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords低酸素応答 / 遺伝子改変マウス / エリスロポエチン / 個体発生 / 低酸素 / 細胞保護 / 細胞分化 / 転写制御 / 造血制御
Outline of Final Research Achievements

Recent studies suggested that the erythroid growth factor erythropoietin (EPO) has roles beyond its canonical erythropoietic function. This study aimed to elucidate in vivo function of EPO in non-erythropoietic cells, and demonstrated roles of EPO in cardiovascular protection and metabolic regulation in mice. Additionally, the mechanism that EPO promotes iron use synchronized with erythropoiesis was unveiled. Our previous studies discovered that embryonic neural cells express the EPO gene, which is known to be mainly produced by adult kidneys. This study added information that the proximal upstream region of the EPO gene directs EPO production in embryonic neural cells. Furthermore, immortalized cell lines derived from the EPO-producing neural cells were established, and analyses of the cell lines demonstrated that the EPO-producing neural cells consist of various types of neural cells. These results imply additional roles of EPO beyond erythropoiesis and propose their molecular bases.

Academic Significance and Societal Importance of the Research Achievements

EPOは30年間臨床現場で貧血治療に利用されているが、本研究では、EPOの赤血球造血以外の作用に迫ることができた。この成果は、臓器保護や鉄代謝改善に対して、EPO製剤が有効である可能性を示唆している。また、EPOは神経系細胞においても細胞保護に作用することが示唆されているが、本研究では、EPOを産生する神経系細胞を同定し、それらの性状を明らかにした。さらに、神経系細胞におけるEPO遺伝子発現制御機構の解明を進めた。以上の研究を発展させることにより、EPO製剤の神経保護作用と作用機序が明らかになると期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (64 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (4 results) Journal Article (30 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 24 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (30 results) (of which Int'l Joint Research: 6 results,  Invited: 16 results)

  • [Int'l Joint Research] Karolinska Institute(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(シンガポール)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(Sweden)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National University of Singapore(Singapore)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters.2018

    • Author(s)
      Suzuki N, Vojnovic N, Lee KL, Yang H, Gradin K, Poellinger L.
    • Journal Title

      Exp Cell Res

      Volume: 366 Issue: 2 Pages: 181-191

    • DOI

      10.1016/j.yexcr.2018.03.020

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018

    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Issue: 3 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF12018

    • Author(s)
      Sekine Hiroki、Okazaki Keito、Kato Koichiro、Alam M. Morshedul、Shima Hiroki、Katsuoka Fumiki、Tsujita Tadayuki、Suzuki Norio、Kobayashi Akira、Igarashi Kazuhiko、Yamamoto Masayuki、Motohashi Hozumi
    • Journal Title

      Molecular and Cellular Biology

      Volume: 38 Issue: 17 Pages: 00252-18

    • DOI

      10.1128/mcb.00252-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts2018

    • Author(s)
      Suzuki Norio、Matsuo-Tezuka Yukari、Sasaki Yusuke、Sato Koji、Miyauchi Kenichiro、Kato Koichiro、Saito Sakae、Shimonaka Yasushi、Hirata Michinori、Yamamoto Masayuki
    • Journal Title

      Kidney International

      Volume: 94 Issue: 5 Pages: 900-911

    • DOI

      10.1016/j.kint.2018.06.028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エリスロポエチンによる赤血球造血制御のメカニズム2018

    • Author(s)
      鈴木教郎
    • Journal Title

      血液フロンティア

      Volume: 28 Pages: 1301-1308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎障害によるエリスロポエチン産生低下の分子機構2018

    • Author(s)
      宮内健一郎, 鈴木教郎
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 8 Pages: 103-107

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎エリスロポエチン産生細胞と腎線維化2018

    • Author(s)
      佐藤浩司, 鈴木教郎
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 7 Pages: 357-362

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸素恒常性維持における赤血球造血系の役割とその破綻による病態への影響2018

    • Author(s)
      鈴木教郎
    • Journal Title

      臨床病理 (2018)

      Volume: 66 Pages: 86-93

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体内酸素環境と赤血球造血制御系の相互作用2018

    • Author(s)
      鈴木教郎
    • Journal Title

      細胞

      Volume: 50 Pages: 18-21

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸素恒常性維持における赤血球造血系の役割とその破綻による病態への影響2018

    • Author(s)
      鈴木 教郎
    • Journal Title

      臨床病理

      Volume: 66 Pages: 86-93

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠高血圧マウスにおけるNrf2不活性化は胎盤血管新生の促進を介して母体と胎仔の症状を改善する2018

    • Author(s)
      袮津昌広, 相馬友和, 鈴木教郎*, 山本雅之
    • Journal Title

      サイエンス・シグナリングに載った日本人研究者

      Volume: 2017 Pages: 10-11

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Regulation of hypoxia-inducible gene expression after HIF activation2017

    • Author(s)
      Suzuki Norio、Gradin Katarina、Poellinger Lorenz、Yamamoto Masayuki
    • Journal Title

      Exp Cell Res

      Volume: 356 Issue: 2 Pages: 182-186

    • DOI

      10.1016/j.yexcr.2017.03.013

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes2017

    • Author(s)
      Nezu Masahiro、Souma Tomokazu、Yu Lei、Sekine Hiroki、Takahashi Nobuyuki、Wei Andrew Zu-Sern、Ito Sadayoshi、Fukamizu Akiyoshi、Zsengeller Zsuzsanna K.、Nakamura Tomohiro、Hozawa Atsushi、Karumanchi S. Ananth、Suzuki Norio、Yamamoto Masayuki
    • Journal Title

      Sci Signal

      Volume: 10 Issue: 479

    • DOI

      10.1126/scisignal.aam5711

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression2017

    • Author(s)
      Nezu Masahiro、Suzuki Norio、Yamamoto Masayuki
    • Journal Title

      Am J Nephrol

      Volume: 45 Issue: 6 Pages: 473-483

    • DOI

      10.1159/000475890

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements2017

    • Author(s)
      Hirano I, Suzuki N, Yamazaki S, Sekine H, Minegishi N, Shimizu R, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 4

    • DOI

      10.1128/mcb.00451-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficient anemic mice2016

    • Author(s)
      Suzuki N, Sasaki Y, Kato K, Yamazaki S, Kurasawa M, Yorozu K, Shimonaka Y, Yamamoto M.
    • Journal Title

      Haematologica

      Volume: 101 Issue: 9 Pages: 356-360

    • DOI

      10.3324/haematol.2015.140814

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression2016

    • Author(s)
      Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M.
    • Journal Title

      Kidney Int

      Volume: 91 Issue: 2 Pages: 387

    • DOI

      10.1016/j.kint.2016.08.023

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 尿細管間質とエリスロポエチン産生細胞2016

    • Author(s)
      鈴木教郎, 山本雅之
    • Journal Title

      医学のあゆみ

      Volume: 257 Pages: 1151-1155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] REP細胞におけるEPO産生制御機構2016

    • Author(s)
      鈴木教郎
    • Journal Title

      腎・高血圧の最新治療

      Volume: 5 Pages: 63-67

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エリスロポエチン産生細胞の同定と機能解析2016

    • Author(s)
      宮内健一郎, 鈴木教郎
    • Journal Title

      最新医学

      Volume: 71 Pages: 123-128

    • NAID

      40021029765

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling2016

    • Author(s)
      Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki
    • Journal Title

      Journal of the american society of nephlorogy

      Volume: 27 Issue: 2 Pages: 428-438

    • DOI

      10.1681/asn.2014121184

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis.2016

    • Author(s)
      Suzuki N, Yamamoto M
    • Journal Title

      Pflugers Arch. Eur. J. Physiol.

      Volume: 468 Issue: 1 Pages: 3-12

    • DOI

      10.1007/s00424-015-1740-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression.2016

    • Author(s)
      Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 3 Pages: 407-420

    • DOI

      10.1128/mcb.00785-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.2015

    • Author(s)
      Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Issue: 15 Pages: 2658-2672

    • DOI

      10.1128/mcb.00161-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Renal erythropoietin-producing cells in health and disease.2015

    • Author(s)
      Souma T, Suzuki N, Yamamoto M
    • Journal Title

      Front Physiol.

      Volume: 3 Pages: 167-167

    • DOI

      10.3389/fphys.2015.00167

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 赤血球造血制御による個体レベルの酸素恒常性維持機構2015

    • Author(s)
      鈴木教郎
    • Journal Title

      実験医学

      Volume: 6 Pages: 1724-1730

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 赤血球増殖因子の産生機能の解明2015

    • Author(s)
      鈴木教郎
    • Journal Title

      東北医学雑誌

      Volume: 127 Pages: 26-28

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 造血因子エリスロポエチンを産生する細胞の単離解析2015

    • Author(s)
      鈴木教郎
    • Journal Title

      東北医学雑誌

      Volume: 127 Pages: 59-60

    • Related Report
      2015 Annual Research Report
  • [Journal Article] EPO産生制御機構2015

    • Author(s)
      祢津昌広, 鈴木教郎, 山本雅之
    • Journal Title

      腎と透析

      Volume: 79 Pages: 88-93

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 腎線維化と腎性貧血2015

    • Author(s)
      相馬友和, 鈴木教郎
    • Journal Title

      日本腎臓学会誌

      Volume: 57 Pages: 1193-1199

    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎臓エリスロポエチン産生細胞『REP細胞』の正常と病態の分子機構2018

    • Author(s)
      鈴木教郎
    • Organizer
      沖縄県腎フォーラム特別講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 低酸素・酸化ストレスと腎臓線維化2018

    • Author(s)
      鈴木教郎
    • Organizer
      第2回Fibrosis
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 腎エリスロポエチン産生細胞『REP細胞』2018

    • Author(s)
      鈴木教郎
    • Organizer
      第10回OCU-CKD研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Erythropoietic induction in response to systemic hypoxia through renal erythropoietin producing (REP) cells2018

    • Author(s)
      鈴木教郎
    • Organizer
      WCP2018 KYOTO Satellite Symposia
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 赤血球増殖因子エリスロポエチンの低酸素誘導的産生制御機構2018

    • Author(s)
      鈴木教郎
    • Organizer
      第91回日本生化学会大会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Maintenance of oxygen homeostasis by erythropoietic regulation and its disorder related to diseases2018

    • Author(s)
      Koji Sato, Norio Suzuki
    • Organizer
      Keystone Symposium on Adaptations to Hypoxia in Physiology and Disease
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎エリスロポエチン産生細胞 「REP細胞」の細胞株樹立と腎臓線維化機構の解析2018

    • Author(s)
      佐藤浩司, 平野育生, 関根弘樹, 宮内健一郎, 加藤幸一郎, 伊藤貞嘉, 山本雅之, 鈴木教郎
    • Organizer
      日本生化学会東北支部 第84回例会・シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腎エリスロポエチン産生細胞 (REP細胞) 由来の細胞株は細胞自律性TGFβ発現により筋線維芽細胞の形質を有する2018

    • Author(s)
      佐藤浩司, 平野育生, 関根弘樹, 宮内健一郎, 加藤幸一郎, 伊藤貞嘉, 山本雅之, 鈴木教郎
    • Organizer
      第91回日本生化学会大会シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 貧血による血圧低下と腎エリスロポエチン細胞におけるレニン産生誘導2018

    • Author(s)
      宮内健一郎, 伊藤貞嘉, 山本雅之, 鈴木教郎
    • Organizer
      第27回腎とエリスロポエチン研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of renal erythropoietin-producing (REP) cells in hypoxia-inducible erythropoiesis2017

    • Author(s)
      Norio Suzuki, Ikuo Hirano, Aina Fukuda, Sakae Saito, Ken-ichiro Miyauchi, Hiroki Sekine, Masayuki Yamamoto
    • Organizer
      Keystone Symposium "Adaptations to Hypoxia in Physiology and Disease"
    • Place of Presentation
      Whistler, Canada
    • Year and Date
      2017-03-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素と酸化ストレスに対する生体防御機構の腎臓での役割2017

    • Author(s)
      鈴木教郎
    • Organizer
      日本腎臓学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 個体の酸素恒常性維持機構とその破綻による疾患への影響2017

    • Author(s)
      鈴木教郎
    • Organizer
      NCGMセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 腎臓病におけるエリスロポエチン産生抑制の分子機構2017

    • Author(s)
      鈴木教郎
    • Organizer
      Tohoku Academy of Erythropoietin
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 酸素恒常性維持における赤血球造血系の役割とその破綻による病態への影響2017

    • Author(s)
      鈴木教郎
    • Organizer
      第57回日本臨床化学会年次学術集会 教育講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 貧血は低血圧を招来し腎レニン発現を誘導する2017

    • Author(s)
      宮内健一郎 加藤幸一郎 袮津昌広 齋藤さかえ 佐藤浩司 山本雅之 鈴木教郎
    • Organizer
      ConBio 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腎臓における低酸素・酸化ストレス応答機構2017

    • Author(s)
      鈴木教郎
    • Organizer
      広島大学 分子細胞情報学セミナー
    • Place of Presentation
      広島大学, 広島市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 妊娠高血圧マウスでは、Nrf2 の欠損は、胎盤血管の発育を促し、周産期合併症を改善させる2016

    • Author(s)
      祢津昌広, 相馬友和, 干 磊, 伊藤貞嘉, 高橋信行, 鈴木教郎, 山本雅之
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台国際センター, 仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] エリスロポエチンによる赤血球の代謝制御2016

    • Author(s)
      福田愛菜, 加藤幸一郎, 河野あかり, 齋藤さかえ, 山本雅之, 鈴木教郎
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター, 仙台
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nrf2 deficiency alleviates perinatal complications in pregnancy-associated hypertension mice via enhancing placental angiogenesis2016

    • Author(s)
      Nezu M, Souma T, Yu L, Sekine H, Moriguchi T, Takahashi N, Ito S, Suzuki N, Yamamoto M
    • Organizer
      The 26th Meeting of International Society of Hypertension
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎臓エリスロポエチン産生細胞『REP細胞』の正常と病態の分子機構2016

    • Author(s)
      鈴木教郎
    • Organizer
      城南腎臓病セミナー
    • Place of Presentation
      八芳園, 東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 低酸素応答における赤血球造血誘導2016

    • Author(s)
      鈴木教郎
    • Organizer
      第16回抗加齢医学会
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 腎性貧血にかかわる分子機構2016

    • Author(s)
      鈴木教郎
    • Organizer
      第61回日本透析医学会
    • Place of Presentation
      大阪国際会議場, 大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 造血因子エリスロポエチンの低酸素誘導的産生制御機構2016

    • Author(s)
      鈴木教郎
    • Organizer
      第4回低酸素研究会
    • Place of Presentation
      早稲田大学TWInS, 東京
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 低酸素ストレスに対する造血誘導の分子機構2016

    • Author(s)
      鈴木教郎
    • Organizer
      佐島シンポジウム
    • Place of Presentation
      東北大学星陵オーディトリアム, 仙台
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Mechanism of transcriptional activation of HIF-target genes after HIF activation2016

    • Author(s)
      Norio Suzuki
    • Organizer
      Lorenz Poellinger Memorial Symposium
    • Place of Presentation
      岐阜グランドホテル, 岐阜
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Erythropoietic Response to Hypoxia2016

    • Author(s)
      Norio Suzuki
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター, 仙台
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素環境におけるエリスロポエチンを介した赤血球代謝制御機構2016

    • Author(s)
      福田愛菜, 加藤幸一郎, 河野あかり, 齋藤さかえ, 山本雅之, 鈴木教郎
    • Organizer
      第4回低酸素研究会
    • Place of Presentation
      早稲田大学TWInS, 東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] EPO欠乏性貧血マウスにおけるC.E.R.A.の造血作用機序2016

    • Author(s)
      鈴木教郎, 山本雅之
    • Organizer
      第24回腎とエリスロポエチン研究会
    • Place of Presentation
      品川プリンスホテル, 東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hypoxia signaling cascade for in vivo erythropoietin production2015

    • Author(s)
      Norio Suzuki, Hiroki Sekine, Tomokazu Souma, Yutaka Tojo, Masahiro Nezu, Toshio Miyata, Masayuki Yamamoto
    • Organizer
      Keystone Symposium on Hypoxia
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2015-05-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chromatin dynamics of hypoxia regulated genes.2015

    • Author(s)
      Norio Suzuki, Nikola Vojnovic, Michael Gralla, Katarina Gradin, Lorenz Poellinger
    • Organizer
      Keystone Symposium on Hypoxia
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2015-05-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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