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Nuclear redox regulation and its roles in pathological basis of aging-related diseases

Research Project

Project/Area Number 15H04692
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

Motohashi Hozumi  東北大学, 加齢医学研究所, 教授 (00282351)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords内因性親電子性物質 / ホルムアルデヒド / DNA損傷 / 酸化ストレス / 親電子性物質 / レドックス制御 / イオウ代謝 / ポリスルフィド / 核酸 / タンパク質 / 生理活性物質 / エピゲノム / 転写複合体 / 遺伝子 / ストレス
Outline of Final Research Achievements

It has been recognized that various active redox reactions take place in the nucleus together with epigenetic regulation and DNA recombination and repair. However, regulatory mechanisms of these intranuclear redox reactions as well as pathological conditions caused by their defects have not been well understood. In this study, we aimed at clarifying effects of endogenous electrophiles on genome and epigenome. Functional relations between ADH5, which is a detoxification enzyme of formaldehyde, and FANCD2, which is one of the DNA repair factors, were examined. And redox-sensitive regulatory mechanisms of ADH5 enzymatic activity were also examined.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (151 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (33 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 29 results,  Open Access: 19 results,  Acknowledgement Compliant: 5 results) Presentation (111 results) (of which Int'l Joint Research: 24 results,  Invited: 41 results) Remarks (5 results)

  • [Int'l Joint Research] University of Delaware/University of California, Los Angeles/Harvard Medical School(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] CEA(France)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Nucleomethylin deficiency impairs embryonic erythropoiesis2018

    • Author(s)
      Murakami Shohei、Suzuki Takuma、Yokoyama Wataru、Yagi Satoko、Matsumura Keita、Nakajima Yuka、Harigae Hideo、Fukamizu Akiyoshi、Motohashi Hozumi
    • Journal Title

      J. Biochem.

      Volume: 印刷中 Issue: 5 Pages: 413-423

    • DOI

      10.1093/jb/mvx086

    • NAID

      40021555326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systemic activation of NRF2 alleviates lethal autoimmune inflammation in Scurfy mice2017

    • Author(s)
      Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 15

    • DOI

      10.1128/mcb.00063-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model2017

    • Author(s)
      Kitamura H、Onodera Y、Murakami S、Suzuki T、Motohashi H
    • Journal Title

      Oncogene

      Volume: 36 Issue: 45 Pages: 6315-6324

    • DOI

      10.1038/onc.2017.236

    • NAID

      130007902444

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NRF2 activation impairs quiescence and bone marrow reconstitution capacity of hematopoietic stem cells2017

    • Author(s)
      Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H
    • Journal Title

      Mol Cell Biol

      Volume: 37 Issue: 19

    • DOI

      10.1128/mcb.00086-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells2017

    • Author(s)
      Rodrigues-Moreira S, Moreno SG, Ghinatti G, Lewandowski D, Hoffschir F, Ferri F, Gallouet A-S, Gay D, Motohashi H, Yamamoto M, Joiner MC, Gault N, Romeo P-H
    • Journal Title

      Cell Rep

      Volume: 20 Issue: 13 Pages: 3199-3211

    • DOI

      10.1016/j.celrep.2017.09.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau2017

    • Author(s)
      Shimizu Taiki、Uchida Chiyoko、Shimizu Ritsuko、Motohashi Hozumi、Uchida Takafumi
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 493 Issue: 2 Pages: 946-951

    • DOI

      10.1016/j.bbrc.2017.09.115

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017

    • Author(s)
      Akaike Takaaki、、、Nishida Motohiro(4)、、、、、、Fujii Shigemoto(20)、、、Motohashi Hozumi(26)
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1177-1177

    • DOI

      10.1038/s41467-017-01311-y

    • NAID

      120007134656

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 環境応答の転写制御シグナル―KEAP1-NRF2制御系―2017

    • Author(s)
      鈴木琢磨、本橋ほづみ
    • Journal Title

      最新医学

      Volume: 72 Pages: 703-709

    • Related Report
      2017 Annual Research Report
  • [Journal Article] The Keap1-Nrf2 System:a Thiol-Based Sensor-Effecotr Apparatus for the Maintenance of Redox Homeostasis2017

    • Author(s)
      Yamamoto M, Kensler TW, Motohashi H
    • Journal Title

      Physiological Review

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] KEAP1-NRF2制御系による酸化ストレス応答と抗老化作用2017

    • Author(s)
      本橋ほづみ
    • Journal Title

      実験医学

      Volume: 35 Pages: 3369-3373

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activatpr NRF22017

    • Author(s)
      Alam MM, Okazaki K, Nguyen LTT, Ota N, Kitamura H, Murakami S, Shima H, Igarashi K, Sekine H, Motohashi H
    • Journal Title

      J Biol Chem

      Volume: 印刷中 Issue: 18 Pages: 7519-7530

    • DOI

      10.1074/jbc.m116.773960

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.2016

    • Author(s)
      Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.
    • Journal Title

      Nat Commun

      Volume: 7 Issue: 1 Pages: 11624-11624

    • DOI

      10.1038/ncomms11624

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming2016

    • Author(s)
      Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T et al.
    • Journal Title

      Nature Commun

      Volume: 7 Issue: 1 Pages: 12030-12030

    • DOI

      10.1038/ncomms12030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD271 regulates the proliferation and motility of hypopharyngeal cancer cells2016

    • Author(s)
      Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, Motohashi H, Sugamura K, Tanaka N
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 30707-30707

    • DOI

      10.1038/srep30707

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The structural origin of metabolic quantitative diversity2016

    • Author(s)
      Koshiba S, Motoike I, Kojima K, Hasegawa T, Shirota M, Saito T, Saigusa D, Danjoh I, Katsuoka F, Ogishima S, ... Yamamoto M.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 31463-31463

    • DOI

      10.1038/srep31463

    • URL

      https://pure.teikyo.jp/en/publications/f23f66dd-859e-4088-8e53-de40d99cc561

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of protocols for global metabolomics by LC-MS for biomarker discovery2016

    • Author(s)
      Saigusa D, Okamura Y, Motoike IN, Katoh Y, Kurosawa Y, Saijyo R, Koshiba S, Yasuda J, Motohashi H, Sugawara J, Tanabe O, Kinoshita K, Yamamoto M
    • Journal Title

      PLoS One

      Volume: 11 Issue: 8 Pages: e0160555-e0160555

    • DOI

      10.1371/journal.pone.0160555

    • URL

      https://pure.teikyo.jp/en/publications/789e31b9-dbb0-4124-986b-c259a28c9328

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 12016

    • Author(s)
      Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 480 Issue: 2 Pages: 180-186

    • DOI

      10.1016/j.bbrc.2016.10.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 91-98

    • DOI

      10.3164/jcbn.15-111

    • NAID

      130005132519

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys.

      Volume: 595 Pages: 140-146

    • DOI

      10.1016/j.abb.2015.11.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 酸化ストレス応答転写因子NRF2の転写制御機構2016

    • Author(s)
      関根弘樹、本橋ほづみ
    • Journal Title

      実験医学

      Volume: 34 Pages: 2517-2524

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in elucidating KEAP1-NRF2 functions in hematopoietic/immune cells and leukemic cells2016

    • Author(s)
      Murakami S, Motohashi H
    • Journal Title

      Rinsho Ketsueki

      Volume: 57 Pages: 1860-1868

    • NAID

      130005420735

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation.2016

    • Author(s)
      Santoso A, Kikuchi T, Tode N, Hirano T, Komatsu R, Damayanti T, Motohashi H, Yamamoto M, Kojima T, Uede T, Nukiwa T, Ichinose M.
    • Journal Title

      Mol Ther.

      Volume: 24 Issue: 1 Pages: 41-52

    • DOI

      10.1038/mt.2015.153

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression.2016

    • Author(s)
      Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 3 Pages: 407-420

    • DOI

      10.1128/mcb.00785-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The transcription factor Bach2 is phosphorylated at multiple sites in murine B cells but a single site prevents its nuclear localization2016

    • Author(s)
      Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K
    • Journal Title

      J Biol Chem

      Volume: 291 Issue: 4 Pages: 1826-1840

    • DOI

      10.1074/jbc.m115.661702

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea2016

    • Author(s)
      Honkura, Y. Matsuo, H. Murakami, S. Sakiyama, M. Mizutari, K. Shiotani, A. Yamamoto, M. Morita, I. Shinomiya, N. Kawase, T. Katori, Y. Motohashi, H.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 19329-19329

    • DOI

      10.1038/srep19329

    • NAID

      130005260938

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of Nrf2 in cell proliferation and differentiation2015

    • Author(s)
      Shohei Murakami and Hozumi Motohashi.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 88 Pages: 168-178

    • DOI

      10.1016/j.freeradbiomed.2015.06.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 巨核球分化と遺伝子発現・調節2015

    • Author(s)
      本橋ほづみ
    • Journal Title

      Thrombosis Medicine

      Volume: 5 (2) Pages: 113-118

    • Related Report
      2015 Annual Research Report
  • [Journal Article] NRF2による転写制御機構と細胞の分化・増殖・がん化における貢献2015

    • Author(s)
      関根弘樹、本橋ほづみ
    • Journal Title

      医学のあゆみ 別冊 レドックスUPDATE

      Volume: 別冊 Pages: 36-40

    • Related Report
      2015 Annual Research Report
  • [Journal Article] An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and diseases2015

    • Author(s)
      Anand D, Kakrana A, Agrawal S, Siddam A, Motohashi H, Yamamoto M, Lachke SA
    • Journal Title

      Genom Data

      Volume: 2 Pages: 223-227

    • DOI

      10.1016/j.gdata.2015.06.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract2015

    • Author(s)
      Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA
    • Journal Title

      Hum Genet

      Volume: 134 Issue: 7 Pages: 717-735

    • DOI

      10.1007/s00439-015-1554-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo2015

    • Author(s)
      Ota C, Yamada M, Fujino N, Motohashi H, Tando Y, Takei Y, Suzuki T, Takahashi T, Kamata S, Makiguchi T, Yamaya M, Kubo H
    • Journal Title

      Exp Lung Res

      Volume: 41 Pages: 422-434

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-body in vivo monitoring of inflammatory diseases exploiting human interleukin 6-luciferase transgenic mice2015

    • Author(s)
      Hayashi M, Takai J, Yu L, Motohashi H, Moriguchi T, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 35 Issue: 20 Pages: 3590-3601

    • DOI

      10.1128/mcb.00506-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap12015

    • Author(s)
      Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.
    • Journal Title

      Science Signaling.

      Volume: 8 Issue: 404 Pages: 404-404

    • DOI

      10.1126/scisignal.aad0667

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] NRF2依存性がん細胞におけるNRF2による転写活性化機構の解明2018

    • Author(s)
      岡崎慶斗、安澤隼人、勝岡史城、田高周、元池育子、山本雅之、木下賢吾、関根弘樹、本橋ほづみ
    • Organizer
      新学術領域研究「酸素生物学・ダイイングコード」合同若手会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5によるホルムアルデヒド解毒代謝機構とタンパク質ポリスルフィド化による制御2018

    • Author(s)
      藤井重元、笠松真吾、Md. Morshedul Alam、井田智章、守田匡伸、居原秀、西村明、松永哲郎、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 活性イオウ分子種定量解析システムの開発と新しいシステインパースルフィド合成高エオの発見2018

    • Author(s)
      井田智章、守田匡伸、魏研范、松永哲郎、西村明、居原秀、澤智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリア/イオウ呼吸選択的Sulfide-quinone reductase (SQR:硫化水素キノン還元酵素)欠損マウスの開発2018

    • Author(s)
      守田匡伸、南嶋洋司、井田智章、松永哲郎、西村明、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第17回分子予防環境医学研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NRF2依存性がんにおけるイオウ代謝2018

    • Author(s)
      本橋ほづみ
    • Organizer
      日本学術会議公開シンポジウム「がんと代謝~;新たな研究領域の創生から革新的な治療薬開発へ~」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生体の酸化ストレス応答機構とその破綻がもたらす疾患2018

    • Author(s)
      本橋ほづみ
    • Organizer
      八戸市医師会生涯教育講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性がんの成立と悪性化機構2018

    • Author(s)
      本橋ほづみ
    • Organizer
      日本消化器癌発生学会特別推進 理事長直轄プロジェクト「癌代謝からみた発癌・進展メカニズム解明の新展開」(基調講演)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Metabolic and transcirpitonal features of NRF2 addicted cancers2018

    • Author(s)
      Motohashi H
    • Organizer
      Cancer Colloquium XIII
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2依存性がんの成立と悪性化機構2018

    • Author(s)
      本橋ほづみ
    • Organizer
      京都大学放射線生物研究センターセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Metabolic features of NRF2 addicted cancers2018

    • Author(s)
      Motohashi H
    • Organizer
      Cancer and Metabolism. Cold Spring Harbor Asia.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 8-ニトロcGMPとタンパク質poly-S-グアニル化による親電子シグナルの可逆制御2017

    • Author(s)
      赤司壮一郎、笠松真吾、ジョン ミンギョン、松永哲郎、井田智章、藤井重元、澤 智裕、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5タンパク質ポリスフリド化の酵素活性制御機能2017

    • Author(s)
      Chazia Glulamo Abdula、笠松真吾、西村明、Md. Morshedul Alam、井田智章、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細菌のイオウ呼吸はすべての生物種に保存されている:哺乳類における新しいエネルギー代謝経路・イオウ呼吸の発見2017

    • Author(s)
      赤池孝章, 井田智章, 松永哲郎, 守田匡伸, 笠松真吾, 西村 明, 藤井重元, 居原 秀, ジョン ミンギョン, 赤司壮一郎, 澤 智裕, 本橋ほづみ
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有機水銀定量曝露による細胞内システインパースルフィドの分解消耗と親電子シグナルの破綻2017

    • Author(s)
      井田智章、笠松真吾、居原秀、ヒシャム アブドル ハミル、チャジア グラモ アブドドゥラ、津々木博康、澤智裕、熊谷嘉人、本橋ほづみ、西田基宏、赤池孝章
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本市国際交流会館(熊本)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Systemic activation of NRF2 alleviates lethal autoimmune inflammation in Scurfy mice2017

    • Author(s)
      Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H
    • Organizer
      TFC Conference “Aging Science”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Young AppNL-GF/NL-GF mice show a mild impairment of cognitive function:a preliminary report2017

    • Author(s)
      Ryoke R, Nonaka H, Saito T, Saido TC, Kawashima R, Motohash H
    • Organizer
      TFC Conference “Bioinformatics and Preventive Medicine”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アルコールデヒドロゲナーゼ5の酵素活性制御におけるタンパク質ポリスルフィド化の機能2017

    • Author(s)
      井田智章、笠松真吾、Md. Morshedul Alam、守田匡伸、居原秀、西村明、松永哲郎、藤井重元、本橋ほづみ、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] システインtRNA合成酵素によるミトコンドリア形態および機能の制御2017

    • Author(s)
      松永哲郎、井田智章、魏范研、西村明幸、守田匡伸、藤井重元、西田基宏、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第17回日本NO学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Glucocorticoid receptor signaling represses antioxidant response by inhibiting NRF2-dependent histone acetylation2017

    • Author(s)
      Alam MM, Okazaki K, Ota N, Kitamura H, Shima H, Igarashi K, Sekine H, Motohashi H
    • Organizer
      日本生化学会東北支部会第83回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NRF2依存性がん細胞におけるNRF2による転写活性化機構の解明2017

    • Author(s)
      岡崎慶斗、安澤隼人、勝岡史城、田高周、元池育子、山本雅之、木下賢吾、関根弘樹、本橋ほづみ
    • Organizer
      日本生化学会東北支部会第83回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] イオウ呼吸とイオウストレス:哺乳類における新しいエネルギー代謝とレドックス病態2017

    • Author(s)
      赤池孝章、西村明、井田智章、松永哲郎、守田匡伸、本橋ほづみ
    • Organizer
      生理研オルガネラ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポリサルファー化によるアルコール脱水素酵素5の酵素活性制御2017

    • Author(s)
      本橋ほづみ、西村明、守田匡伸、Md. Morshedul Alam、井田智章、赤池孝章
    • Organizer
      生理研オルガネラ研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] システイニルtRNA合成酵素によるミトコンドリア機能制御の解明2017

    • Author(s)
      松永哲郎、井田智章、魏范研、澤智裕、守田匡伸、西村明、笠松真吾、田沼延公、藤井重元、島礼、居原秀、西田基宏、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5タンパク質ポリスルフィド化の酵素活性制御機構2017

    • Author(s)
      Jung Minkyung、西村明、笠松真吾、Md. Morshedul Alam、井田智章、松永哲郎、藤井重元、居原秀、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規システインパースルフィド合成酵素の同定と機能解析2017

    • Author(s)
      井田智章、守田匡伸、魏研范、松永哲郎、西村明、Jun Minkyung、赤司壮一郎、居原秀、澤智裕、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第70回日本酸化ストレス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] O-GlcNAcylation signal confers resistance to proteasome inhibitors on cancer cells by increasing NRF1 stability2017

    • Author(s)
      Sekine H, Okazaki K, Alam MM, Motohashi H
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-11 contributes to tumorigenesis in an NRF2 addiction cancer model2017

    • Author(s)
      Kitamura H,Onodera Y,Suzuki T,Motohashi H
    • Organizer
      SfRBM 24th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニトロソグルタチオン還元酵素(GSNOR)選択的欠損マウスの開発2017

    • Author(s)
      松永哲郎、西村明、笠松真吾、Md. Morshedul Alam、井田智章、守田匡伸、居原秀、藤井重元、下田翔、 西田基宏、本橋ほづみ、赤池孝章
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NRF2活性化はKras変異を伴う肺腺がんへの炎症細胞浸潤を促進する2017

    • Author(s)
      林真貴子、久我有祐美、本橋ほづみ、鈴木未来子、山本雅之
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pin1によるtauを介した巨核球胞体系性制御機構2017

    • Author(s)
      清水泰希、菅原佑衣、広瀬恵子、清水律子、本橋ほづみ、内田千代子、内田隆史
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of NRF2 activity for anti-inflammation and stem cell maintenance2017

    • Author(s)
      Motohashi H
    • Organizer
      Tohoku Forum for Creativity “Aging Science: from Molecules to Society” Topic 1 “Aging Biology”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポリスルフィド化によるアルコール脱水素酵素5(ADH5)の酵素活性制御2017

    • Author(s)
      本橋ほづみ
    • Organizer
      オルガネラ研究会2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 酸化ストレス応答転写因子NRF2による抗炎症作用2017

    • Author(s)
      本橋ほづみ
    • Organizer
      第17回日本抗加齢医学会総会 「老化の多様性とその代謝特性」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2制御系による抗酸化応答とエイジング2017

    • Author(s)
      本橋ほづみ
    • Organizer
      第44回日本毒性学会学術年会 シンポジウム「抗酸化レドックスと活性イオウによる解毒代謝機構の新展開」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2システムと発がん2017

    • Author(s)
      本橋ほづみ
    • Organizer
      第14回日本病理学会カンファランス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Oxidative stress response and metabolic regulation by KEAP1-NRF2 system in cancers2017

    • Author(s)
      Motohashi H
    • Organizer
      第28回日本消化器癌発生学会総会・第9回国際消化器癌発生会議 シンポジウム「癌代謝を考える-臨床応用への展開を目指して」(基調講演)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2 system for cytoprotection and cancer malignancy2017

    • Author(s)
      Motohashi H
    • Organizer
      Vermont Hematology/Oncology Rounds, College of Medicine, University of Vermont
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Significant contribution of reactive sulfur metabolism to the mitochondrial function2017

    • Author(s)
      Motohashi H
    • Organizer
      第90回日本生化学会大会 シンポジウム「活性イオウ種を介したレドックスシグナリングとエネルギー変換」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2 system in stress responss and cancer malignancy2017

    • Author(s)
      本橋ほづみ
    • Organizer
      Kumamoto University Advence Research Project A & Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers, International Symposium
    • Place of Presentation
      Kumamoto University, Kumamoto
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] KEAP1-NRF2 system in anti-oxidant response and regulation of cell proliferation and senescence2017

    • Author(s)
      本橋ほづみ
    • Organizer
      International Symposium “Redox Signaling in host defense and oxidative stress”, 第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Systemic activation of NRF2 alleviates chronic inflammation in a mouse model of lethal autoimmune diseases2016

    • Author(s)
      鈴木琢磨、村上昌平、張替秀郎、本橋ほづみ
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] KEAP1-NRF2 system as a cysteine-based redox sensor-effector for our defense mechanism2016

    • Author(s)
      本橋ほづみ
    • Organizer
      Lecture series
    • Place of Presentation
      The Jagiellonian University, Krakow, Polamd
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NRF2の活性化がもたらす自己免疫疾患の慢性炎症改善作用2016

    • Author(s)
      鈴木琢磨、村上昌平、山本雅之、張替秀郎、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん細胞におけるNRF2依存性転写活性化機構のゲノムワイドな解析2016

    • Author(s)
      岡崎慶斗、関根弘樹、勝岡史城、植野和子、長﨑正朗、山本雅之、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転写因子NRF1のOGT-HCF-1複合体を介した分解制御機構2016

    • Author(s)
      関根弘樹、加藤幸一郎、福田愛菜、鈴木教郎、辻田忠志、岡崎慶斗、Md. Morshedul Alam、小林聡、山本雅之、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 2-ヒドロキシグルタル酸の精子形成・胎児発生における生理的役割の検討2016

    • Author(s)
      百々美奈、北村大志、太田奈緒、三枝大輔、勝岡史城、千葉初音、岡江寛明、有馬隆博、小関健由、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] KEAP1の体細胞変異がもたらす腫瘍形成能促進機構の解明2016

    • Author(s)
      北村大志、小野寺好明、鈴木貴、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 造血幹細胞におけるKEAP1-NRF2制御系の機能解析2016

    • Author(s)
      村上昌平、山本雅之、本橋ほづみ
    • Organizer
      第89回日本生化学会大会合同大会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 精巣における2-ヒドロキシグルタル酸の産生機構と生理的作用の検討2016

    • Author(s)
      百々美奈、北村大志、太田奈緒、三枝大輔、小関健由、本橋ほづみ
    • Organizer
      日本生化学会東北支部会 第82会例会
    • Place of Presentation
      弘前大学医学部 基礎大講堂(弘前)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] KEAP1の体細胞変異はRASシグナルと協調して腫瘍形成能を促進させる2016

    • Author(s)
      北村大志、本橋ほづみ
    • Organizer
      日本生化学会東北支部会 第82会例会
    • Place of Presentation
      弘前大学医学部 基礎大講堂(弘前)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 致死的自己免疫疾患に対してNRF2の恒常的活性化がもたらす抗炎症作用の解析2016

    • Author(s)
      鈴木琢磨、村上昌平、山本雅之、張替秀郎、本橋ほづみ
    • Organizer
      日本生化学会東北支部会 第82会例会
    • Place of Presentation
      弘前大学医学部 基礎大講堂(弘前)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Translation-coupled protein polysulfation, a unique biosynthesis pathway of cysteine persulfide2016

    • Author(s)
      Ida T, Ihara H, Wei F, Tomizawa K, Kasamatsu S, Matsunaga T, Kumagai Y, Sawa T, Motohashi H, Akaike T
    • Organizer
      The 9th International Conference of the Biology, Chemistry and Theapeutic applications of nitric oxide
    • Place of Presentation
      Sendai International Center (Sendai)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulatory mechanisms of alcohol dehydrogenase 5 activity via protein polysulfuration2016

    • Author(s)
      Kasamatsu S, Md. Morshedul Alam, Ida T, Matsunaga T, Fujii S, Ihara H, Motohashi H, Akaike T
    • Organizer
      The 9th International Conference of the Biology, Chemistry and Theapeutic applications of nitric oxide
    • Place of Presentation
      Sendai International Center (Sendai)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of reactive sulfuer species by ethylmalonic encephalopathy protein 1, persulfide dioxygenase2016

    • Author(s)
      Jung S, Matsuaga T, Kitamura H, Ono K, Ida T, Fujii S, Sawa T, Motohashi H, Akaike T
    • Organizer
      The 9th International Conference of the Biology, Chemistry and Theapeutic applications of nitric oxide
    • Place of Presentation
      Sendai International Center (Sendai)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of mitochondrial energy metabolism by cysteine persulfide produced by mitochondrial cysteinyl-tRNA synthass2016

    • Author(s)
      Sato F, Okutomi M Matsunaga T, Kasamatsu S, Kaneki M, Ida T, Morita M, Tomizawa K, Fujii S, Motohashi H, Akaiake T
    • Organizer
      The 9th International Conference of the Biology, Chemistry and Theapeutic applications of nitric oxide
    • Place of Presentation
      Sendai International Center (Sendai)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of mitochondria biogenesis by cysteine persulfide produced by cysteinyl-tRNA synthetase2016

    • Author(s)
      Nishimura A, Matsunaga T, Ida T, Kasamatsu S, Morita M, Fanyan W, Tomizawa K, Fujii S, Motohashi H, Akaike T
    • Organizer
      The 9th International Conference of the Biology, Chemistry and Theapeutic applications of nitric oxide
    • Place of Presentation
      Sendai International Center (Sendai)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NRF2活性化による強大音曝露に伴う酸化ストレスからの内耳保護効果(1) -Nrf2-/-マウス解析-2016

    • Author(s)
      本蔵陽平、水足邦雄、塩谷彰浩、川瀬哲明、香取幸夫、本橋ほづみ
    • Organizer
      第117回日本耳鼻咽喉科学会通常総会・学術講演会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] KEAP1-NRF2 system in stress response and cancer malignancy2016

    • Author(s)
      Hozumi Motohashi
    • Organizer
      The special seminar at Joslin Diabetes Center
    • Place of Presentation
      Joslin Diabetes Center (Boston, Massachusetts, USA)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Crosstalk between regulation of redox balance and cell proliferation by NRF22016

    • Author(s)
      Hozumi Motohashi
    • Organizer
      The Society of Toxicology, 55th Annual Meeting and ToxExpo
    • Place of Presentation
      Morial Convention Center (New Orleans, Louisiana, USA)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] KEAP1-NRF2 system in malignant progression of cancers2016

    • Author(s)
      本橋ほづみ
    • Organizer
      都大学 生命科学研究科 大学院博士課程「先端生命科学」講義
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] NRF2依存性環境ストレス応答:内耳酸化ストレス障害の軽減に対するNRF2の貢献2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第49回日本毒性学会学術年会 シンポジウム
    • Place of Presentation
      ウインクあいち(愛知県産業労働センター)(名古屋)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] がんの悪性化と酸化ストレス応答機構2016

    • Author(s)
      本橋ほづみ
    • Organizer
      安田女子大学・薬学部・薬学科 10周年記念学術講演会
    • Place of Presentation
      安田女子大学(広島)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2制御系による酸化ストレス応答と細胞老化制御2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第69回日本酸化ストレス学会学術集会 教育講演
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Purification and analysis of endogenous NRF2 complex in the presence and absence of active PI3K-AKT signaling2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第89回日本生化学会大会 シンポジウム「細胞のロバストネスを規定するタンパク質複合体のダイナミクス」
    • Place of Presentation
      仙台国際センター(仙台)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Enhancement mechanisms of NRF2-dependent transcriptional activation in cancer cells がん細胞におけるNRF2依存的転写活性の増強メカニズム2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 造血細胞の分化・増殖における酸化ストレス応答機構の役割2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第78回日本血液学会学術集会 教育講演
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NRF2の活性制御による加齢疾患の予防と治療の可能性2016

    • Author(s)
      本橋ほづみ
    • Organizer
      スマート・エイジングカレッジin東京
    • Place of Presentation
      東京丸の内・東北大学東京分室(東京)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] KEAP1-NRF2制御系による酸化ストレス応答とその破綻2016

    • Author(s)
      本橋ほづみ
    • Organizer
      Marianna Research Council (MRC)
    • Place of Presentation
      聖マリアンナ医科大学(川崎)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Nrf2活性化によるNrf2依存性がんの治療戦略2016

    • Author(s)
      本橋ほづみ
    • Organizer
      日本放射線影響学会 第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NRF2による酸化ストレス応答と細胞老化制御2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第11回臨床ストレス応答学会大会 シンポジウム
    • Place of Presentation
      山口大学医学部(宇部)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Antioxidant response and cell senescence regulation by KEAP1-NRF2 system2016

    • Author(s)
      本橋ほづみ
    • Organizer
      “Frontiers in aging research toward healthy longevity”
    • Place of Presentation
      丸の内MY PLAZAホール(東京)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] KEAP1-NRF2 system in stress response and cancer malignancy2016

    • Author(s)
      本橋ほづみ
    • Organizer
      III International Scienctific Conference: Oxygen 2016
    • Place of Presentation
      The Jagiellonian University, Krakow, Poland
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 酸化ストレス応答機構KEAP1-NRF2経路による細胞老化制御2016

    • Author(s)
      本橋ほづみ
    • Organizer
      第39回日本分子生物学会年会 シンポジウム「エピゲノム制御:疾患発症における意義」
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] NRF2 and ROS metabolism2016

    • Author(s)
      本橋ほづみ
    • Organizer
      Educational session, ESMO Asia 2016
    • Place of Presentation
      Suntec Signapore Convention & Exhibition Centre, Singapore
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A stress-responsive transcriptional factor NRF2 activates hematopoietic stem cells2015

    • Author(s)
      Murakami S, Yamamoto M, Motohashi H
    • Organizer
      The 57th ASH Annual Scientific Meeting and Exposition
    • Place of Presentation
      Orange County Convention Center(Orlando, FL, USA)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がんの悪性化におけるKEAP1-NRF2制御系の貢献2015

    • Author(s)
      本橋ほづみ
    • Organizer
      第1回東北呼吸器外科ベーシックセミナー
    • Place of Presentation
      東北大学加齢医学研究所(仙台)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] タンパク質ポリサルファ化を介したアルコールデヒドロゲナーゼ5の酵素活性制御機構2015

    • Author(s)
      笠松真吾、Md. Morshedul Alam、井田智章、松永哲郎、藤井重元、居原秀、赤池孝章、本橋ほづみ
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明2015

    • Author(s)
      井田智章、居原秀、魏研范、富澤一仁、長尾翌手可、鈴木勉、熊谷嘉人、澤智裕、笠松真吾、本橋ほづみ、赤池孝章
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] KEAP1遺伝子変異はRASシグナルと協調して腫瘍形成を促進する2015

    • Author(s)
      北村大志、本橋ほづみ
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] NRF2-MED16を介した抗酸化遺伝子群の転写活性化機構2015

    • Author(s)
      岡崎慶斗、関根弘樹、鈴木教郎、加藤恭丈、五十嵐和彦、伊藤光宏、本橋ほづみ、山本雅之
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] NRF2活性化による強大音曝露に伴う酸化ストレスからの内耳保護効果の解明2015

    • Author(s)
      本蔵陽平、村上昌平、本橋ほづみ
    • Organizer
      第38回日本分子生物学会年会/第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] A stress-responsbile transcription factor NRF2 alleviates inflammation in autoimmune diseases2015

    • Author(s)
      Shohei Murakami, Takuma Suzuki, Hideo Harigae and Hozumi Motohashi
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cytoprotection and metabolic reprogramming governed by KEAP1-NRF2 system2015

    • Author(s)
      Hozumi Motohashi
    • Organizer
      The 46th International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      Palace Hotel Tokyo (Tokyo)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Manipulated expression of the oxidative DNA/RNA demethylation enzyme ALKBH3 alters cellular proliferation and metabolism2015

    • Author(s)
      稲瀬安希、本橋ほづみ、菅澤薫
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] CD271 marks cancer initiating cells in hypopharyngeal carcinoma with enhanced proliferative potential2015

    • Author(s)
      望月麻衣、本橋ほづみ、田中伸幸
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comprehensive genomic characterization of non-small cell lung cancer cell lines for integrated omics analysis2015

    • Author(s)
      齋藤さかえ、元池育子、潘小青、齊藤智、齋藤るみ子、檀上稲穂、鈴木隆史、本橋ほづみ、木下賢吾、安田純、石井啓文、山本雅之
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細胞のがん化と老化における酸化ストレス応答機構の役割2015

    • Author(s)
      本橋ほづみ
    • Organizer
      東北エイジングサミット-加齢制御研究から臨床まで-
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A stress-responsive transcriptional factor NRF2 activates hematopoietic stem cells2015

    • Author(s)
      Murakami S, Yamamoto M, Motohashi H.
    • Organizer
      44th Annual Scientific Meeting of the ISEH (International Society for Experimetal Hematology)
    • Place of Presentation
      Kyoto International Conference Center (Kyoto)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NRF2 Attenuates Noise-Induced Hearing Loss by Preventing Oxidative Damage of Cochlea2015

    • Author(s)
      Yohei Honkura, Shohei Murakami, Tetsuaki Kawase, Yukio Katori, Hozumi Motohashi
    • Organizer
      The 52nd Inner Ear Biology Workshop - IEB 2015
    • Place of Presentation
      Catholic University of the Sacred Heart (Rome, Italy)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性神経膠腫におけるNRF2経路活性化と予後に関する検討2015

    • Author(s)
      金森政之、比嘉剛志、園田順彦、村上昌平、北村大志、百々美奈、柴田龍弘、渡辺みか、鈴木博義、柴原一陽、斎藤竜太、山下洋二、隈部俊宏、山本雅之、本橋ほづみ、冨永悌二
    • Organizer
      第16回日本分子脳神経外科学会
    • Place of Presentation
      アクトシティ浜松コングレスセンター(浜松)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] NRF2による代謝制御と細胞増殖2015

    • Author(s)
      本橋ほづみ
    • Organizer
      第10回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      慶應義塾大学先端生命科学研究所 メタボロームキャンパスレクチャーホール(鶴岡)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ペルオキシレドキシンによる酵母ピルビン酸キナーゼの活性抑制は糖新生と酸化ストレス応答に寄与する2015

    • Author(s)
      久下周佐、色川隼人、松山由香、本橋ほづみ、岩井健太
    • Organizer
      第3回がんと代謝研究会
    • Place of Presentation
      石川県立音楽堂(金沢)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析2015

    • Author(s)
      井田智章、居原秀、澤智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第15回日本NO学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質S-ポリチオール化によるアルコールデヒドロゲナーゼ5の活性制御機構2015

    • Author(s)
      藤井重元、Md. Morshedul Alam,井田智章、松永哲郎、笠松真吾、居原秀、赤池孝章、本橋ほづみ
    • Organizer
      第15回日本NO学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルコール脱水素酵素III (ADH5)による生体防御機構と代謝制御2015

    • Author(s)
      本橋ほづみ
    • Organizer
      第15回日本蛋白質科学会年会 ワークショップ 酵素リモデリング・レドックスシグナルとタンパク質修飾の新たな潮流
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アルコール脱水素酵素III (ADH5)による生体防御機構と代謝制御2015

    • Author(s)
      本橋ほづみ
    • Organizer
      第15回日本蛋白質科学会年会 ワークショップ
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] KEAP1-NRF2制御系によるストレス応答と代謝制御2015

    • Author(s)
      本橋ほづみ
    • Organizer
      山口大学大学院医学系研究科 大学院セミナー
    • Place of Presentation
      山口大学(宇部)
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] グルタチオン依存性ホルムアルデヒド脱水酵素ADH3による酸化ストレス防御と代謝制御2015

    • Author(s)
      後藤まき、北村大志、Md. Morshedul Alam、長谷場健、山本照子、山本雅之、笠松真吾、井田智章、赤池孝章、本橋ほづみ
    • Organizer
      Research PlaNet2015
    • Place of Presentation
      梅田スカイビルタワーウエスト(大阪)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] NRF2-MED16を介した抗酸化遺伝子群の転写活性化機構2015

    • Author(s)
      関根弘樹、岡崎慶斗、鈴木教郎、本橋ほづみ、山本雅之
    • Organizer
      新学術領域「転写代謝システム」平成27年度領域班会議
    • Place of Presentation
      菊南温泉ユウベルホテル(熊本)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化的脱メチル化酵素ALKBH3の発現変化は細胞増殖や代謝に影響を与える2015

    • Author(s)
      稲瀬安希、本橋ほづみ、菅澤薫
    • Organizer
      新学術領域「転写代謝システム」平成27年度領域班会議
    • Place of Presentation
      菊南温泉ユウベルホテル(熊本)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写環境制御による代謝応答と酸化ストレス応答のクロストーク2015

    • Author(s)
      本橋ほづみ
    • Organizer
      新学術領域「転写代謝システム」平成27年度領域班会議
    • Place of Presentation
      菊南温泉ユウベルホテル(熊本)
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] アルコールデヒドロゲナーゼ5の活性発現におけるタンパク質S-ポリチオール化の役割2015

    • Author(s)
      藤井重元、Md. Morshedul Alam,井田智章、松永哲郎、笠松真吾、居原秀、赤池孝章、本橋ほづみ
    • Organizer
      第68回日本酸化ストレス学会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析2015

    • Author(s)
      井田智章、居原秀、澤智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章
    • Organizer
      第68回日本酸化ストレス学会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質ポリチオール化による親電子シグナル制御2015

    • Author(s)
      赤司壮一郎、笠松真吾、ジョン ミンギョン、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤智裕、熊谷嘉人、赤池孝章
    • Organizer
      第68回日本酸化ストレス学会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 造血幹細胞におけるKEAP1-NRF2制御系の機能解析2015

    • Author(s)
      村上昌平、山本雅之、本橋ほづみ
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] NRF2活性化による音響外傷からの内耳保護効果の解明2015

    • Author(s)
      本蔵陽平、村上昌平、川瀬哲明、香取幸夫、本橋ほづみ
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Human ADH5 polymorphism affect susceptibility to electorphilic stresses2015

    • Author(s)
      Md. Morshedul Alam、笠松真吾、後藤まき、北村大志、井田智章、赤池孝章、本橋ほづみ
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頭頸部がん幹細胞におけるCD271の役割の解明2015

    • Author(s)
      望月麻衣、今井隆之、松浦一登、小鎌直子、玉井恵一、本橋ほづみ、菅村和夫、田中伸幸
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質ポリチオール化制御機構の解明2015

    • Author(s)
      ヒシャム アブドゥル ハミル、井田智章、笠松真吾、魏范研、松永哲郎、赤司壮一郎、ジョン ミンギョン、藤井重元、居原秀、澤智裕、富澤一仁、本橋ほづみ、赤池孝章
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] タンパク質ポリチオール化による親電子シグナル制御2015

    • Author(s)
      赤司壮一郎、笠松真吾、ジョン ミンギョン、松永哲郎、井田智章、藤井重元、本橋ほづみ、澤智裕、熊谷嘉人、赤池孝章
    • Organizer
      日本生化学会東北支部第81回例会
    • Place of Presentation
      東北大学片平さくらホール(仙台)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化ストレス応答と代謝制御のクロストーク2015

    • Author(s)
      本橋ほづみ
    • Organizer
      第88回日本内分泌学会学術総会 シンポジウム エネルギー代謝のエピジェネティクス
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 東北大学加齢医学研究所 遺伝子発現制御分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/ger/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所

    • URL

      http://www.idac.tohoku.ac.jp/site_ja/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所遺伝子発現制御分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/ger/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所 公式HP

    • URL

      http://www.idac.tohoku.ac.jp/ja/activities/research/gene_exp_regulation/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所遺伝子発現制御分野 HP

    • URL

      http://www2.idac.tohoku.ac.jp/dep/ger/

    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2022-10-07  

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