Roles of HIston methyation in retinal defferentiation and maintenance
| Project/Area Number |
15H04695
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 網膜 / エピジェネティクス / ヒストンメチル化 / 発生 / マウス / 分化 / 細胞系列 / 視細胞 / ヒストン / メチル化 / ヒストン修飾 |
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| Outline of Final Research Achievements |
Ezh2 knockout mice retinas showed delay of development of not only photoreceptors, but also other neurons and glias. Therefore, roles of histone H3K27 methylation was suggested to be regulation of timing of cells differentiation. We found histone H3 lysine other than K27 was also involved in retinal development. ChIP-seq showed that the gene loci, which are highly modified this methylation, was also methylated in histone H3K27, suggesting new mechanisms that co-operated regulation of transcription by these two methylations.
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Report
(4 results)
Research Products
(15 results)
