| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
To investigate the TRIC-B function in various cells and tissues, we generated conditional TRIC-B deficient mice instead of conventional TRIC-B knockout mice which died immediately after birth due to impairement of pulmonary alveolous. First, we generated heart-specific TRIC-B deficient mice. Second, we generated mTRIC-B deficient ES cells and differntiated to the central nervous system cell lineage using with the neurosphere method. In heart-specific TRIC-B deficient mice, treatment of tamoxifen decreased gene expression of Tric-b in the heart. In addition, it was suggested that lack of TRIC-B may contribute to the differentiation process to the central nervous system cell lineage.
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