Analysis on the involvement of the new transcriptional elongation regulator Med26 in mixed acute leukemia
Project/Area Number |
15H04701
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | Yokohama City University (2017) Hokkaido University (2015-2016) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
Keywords | 遺伝子発現制御 / 転写 / 転写伸長 / がん / 急性白血病 / 発現制御 / 腫瘍性疾患 / 転写制御 / RNAポリメラーゼII / メディエーター / 腫瘍 / 遺伝子発現 / 白血病 |
Outline of Final Research Achievements |
In this study,we addressed the mechanisms how Med26 and SEC collaborate to release the paused Pol II and clarified the mechanism of promoting tumor growth. Furthermore, we clarified how Med26 regulates the transcriptional expression of the distinct genes by recruiting two distinct transcription elongation complexes SEC and LEC.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy- like syndrome.2018
Author(s)
Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H
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Journal Title
Scientific Reports
Volume: 8
Pages: 819-819
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sez6l2 regulates phosphorylation of ADD and neuritogenesis.2017
Author(s)
Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K.I., Watanabe, M. and Hatakeyama, S.
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Journal Title
Biochem Biophys Res Commun
Volume: 494
Pages: 234-241
DOI
Related Report
Peer Reviewed
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[Journal Article] The novel heart-specific RING finger protein 207 regulates energy metabolism in cardiomyocytes2016
Author(s)
Mizushima, W., Takahashi , H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K.I., Tsutsui, H. and Hatakeyama, S.
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 100
Pages: 43-53
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex.2016
Author(s)
Anwar, D., Takahashia, H., Watanabe, M., Suzuki, M., Fukuda, S., Hatakeyama, S.
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Journal Title
BBA Gene Regulatory Mechanisms
Volume: 1859
Pages: 975-982
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti-phospholipid syndrome.2016
Author(s)
Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T. et al.
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Journal Title
Rheumatology (Oxford)
Volume: 印刷中
Pages: 1117-1126
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Chd5 regulates MuERV-L/MERVL expression in mouse embryonic stem cells via H3K27me3 modification and histone H3.1/H3.2.2016
Author(s)
Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
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Journal Title
J. Cell. Biochem.
Volume: 117
Pages: 780-792
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.2016
Author(s)
Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T. et al.
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Journal Title
Rheumatology
Volume: In press
Related Report
Peer Reviewed
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[Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.2015
Author(s)
Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
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Journal Title
Nature Communications
Volume: 5
Pages: 1-15
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ2015
Author(s)
Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K., and Hatakeyama, S.
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Journal Title
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin2015
Author(s)
Masuda, Y., Takahashi, H., Sato, S., Tomonori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W. and Hatakeyama, S.
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Journal Title
Nature communications
Volume: 6
Pages: 7299-7299
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015
Author(s)
Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, Delnur Anwar, Mio Shibata, Chieri Tomomori-Sato, Shigeo Sato, Amol Ranjan, Chris W. Seidel, Tadasuke Tsukiyama, Wataru Mizushima, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama.
Organizer
Mechanism of Eukaryotic Transcription
Place of Presentation
Cold spring harbor laboratory(NY, USA)
Year and Date
2015-08-25
Related Report
Int'l Joint Research
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