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Analysis on the involvement of the new transcriptional elongation regulator Med26 in mixed acute leukemia

Research Project

Project/Area Number 15H04701
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionYokohama City University (2017)
Hokkaido University (2015-2016)

Principal Investigator

TAKAHASHI Hidehisa  横浜市立大学, 医学研究科, 教授 (30423544)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords遺伝子発現制御 / 転写 / 転写伸長 / がん / 急性白血病 / 発現制御 / 腫瘍性疾患 / 転写制御 / RNAポリメラーゼII / メディエーター / 腫瘍 / 遺伝子発現 / 白血病
Outline of Final Research Achievements

In this study,we addressed the mechanisms how Med26 and SEC collaborate to release the paused Pol II and clarified the mechanism of promoting tumor growth. Furthermore, we clarified how Med26 regulates the transcriptional expression of the distinct genes by recruiting two distinct transcription elongation complexes SEC and LEC.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(22 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation

  • [Int'l Joint Research] Stowers Institute for Medical Research(United states)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Stowers Institute for Medical Research(アメリカ合衆国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy- like syndrome.2018

    • Author(s)
      Yabe I, Yaguchi H, Kato Y, Miki Y, Takahashi H, Tanikawa S, Shirai S, Takahashi I, Kimura M, Hama Y, Matsushima M, Fujioka S, Kano T, Watanabe M, Nakagawa S, Kunieda Y, Ikeda Y, Hasegawa M, Nishihara H, Ohtsuka T, Tanaka S, Tsuboi Y, Hatakeyama S, Wakabayashi K, Sasaki H
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 819-819

    • DOI
      10.1038/s41598-018-19198-0
    • NAID
      120006377499
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sez6l2 regulates phosphorylation of ADD and neuritogenesis.2017

    • Author(s)
      Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K.I., Watanabe, M. and Hatakeyama, S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 494 Pages: 234-241

    • DOI
      10.1016/j.bbrc.2017.10.047
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel heart-specific RING finger protein 207 regulates energy metabolism in cardiomyocytes2016

    • Author(s)
      Mizushima, W., Takahashi , H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K.I., Tsutsui, H. and Hatakeyama, S.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 100 Pages: 43-53

    • DOI
      10.1016/j.yjmcc.2016.09.013
    • NAID
      120006360069
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex.2016

    • Author(s)
      Anwar, D., Takahashia, H., Watanabe, M., Suzuki, M., Fukuda, S., Hatakeyama, S.
    • Journal Title

      BBA Gene Regulatory Mechanisms

      Volume: 1859 Pages: 975-982

    • DOI
      10.1016/j.bbagrm.2016.06.001
    • NAID
      120006328999
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti-phospholipid syndrome.2016

    • Author(s)
      Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T. et al.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 印刷中 Pages: 1117-1126

    • DOI
      10.1093/rheumatology/kew005
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TRIM39 negatively regulates the NFkB-mediated signaling pathway through stabilization of cactin.2016

    • Author(s)
      Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, Hatakeyama S.
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 73 Pages: 1085-1101

    • DOI
      10.1007/s00018-015-2040-x
    • NAID
      120005981342
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chd5 regulates MuERV-L/MERVL expression in mouse embryonic stem cells via H3K27me3 modification and histone H3.1/H3.2.2016

    • Author(s)
      Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
    • Journal Title

      J. Cell. Biochem.

      Volume: 117 Pages: 780-792

    • DOI
      10.1002/jcb.25368
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes.2016

    • Author(s)
      Fujieda Y., Amengual O., Matsumoto M., Kuroki K., Takahashi H., Kono M., Kurita Y., Otomo K., Kato M., Oku K., Bohgaki T., Horita T., Yasuda S., Maenaka K., Hatakeyama S., Nakayama K.I. and Atsumi T. et al.
    • Journal Title

      Rheumatology

      Volume: In press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.2015

    • Author(s)
      Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. and Hatakeyama, S
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 1-15

    • DOI
      10.1038/ncomms6941
    • NAID
      120005621881
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Molecular role of RNF43 in canonical and noncanonical Wnt signaling.2015

    • Author(s)
      T. Tsukiyama,et al.
    • Journal Title

      Molecular and Cellular Biology

      Volume: in press Pages: 2007-2023

    • DOI
      10.1128/mcb.00159-15
    • NAID
      120005672365
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ2015

    • Author(s)
      Watanabe, M., Takahashi, H., Saeki, Y., Ozaki, T., Itoh, S., Suzuki, M., Mizushima, W., Tanaka, K., and Hatakeyama, S.
    • Journal Title

      eLIfe

      Volume: 4

    • DOI
      10.7554/elife.05615
    • NAID
      120005617283
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] TRIM29 regulates the p63-mediated pathway in cervical cancer cells2015

    • Author(s)
      Masuda, Y., Takahashi, H. and Hatakeyama, S.
    • Journal Title

      Biochim. Biophys. Acta-Mol. Cell Res.

      Volume: 1853 Pages: 2296-2305

    • DOI
      10.1016/j.bbamcr.2015.05.035
    • NAID
      120005906885
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin2015

    • Author(s)
      Masuda, Y., Takahashi, H., Sato, S., Tomonori-Sato, C., Saraf, A., Washburn, M.P., Florens, L., Conaway, R.C., Conaway, J.W. and Hatakeyama, S.
    • Journal Title

      Nature communications

      Volume: 6 Pages: 7299-7299

    • DOI
      10.1038/ncomms8299
    • NAID
      120005647269
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Human Mediator subunit MED26 plays a role in 3’-end processing of replication dependent Histone mRNA through recruitment of little elongation complex2017

    • Author(s)
      Hidehisa Takahashi, Mio Shibata, Ichigaku Takigawa, Masashi Watanabe, Junichi Yamamoto, Yuki Yamaguchi, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama
    • Organizer
      CSHL meeting on Mechanisms of Eukaryotic Transcription, Cold Spring Harbor Laboratory
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] メディエーター複合体による転写終結制御機構2017

    • Author(s)
      高橋秀尚,柴田美音,瀧川一学,渡部昌,築山忠維,藤井聡,飯田緑,山本淳一,山口雄輝,Amol Ranjan,Shigeo Sato,Chieri-tomomori Sato,Joan W. Conaway,Ronald C. Conaway,畠山鎮次
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Regulation of transcription termination by Human Mediator complex2016

    • Author(s)
      高橋秀尚,畠山鎮次
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] メディエーター複合体による転写制御機構2016

    • Author(s)
      高橋秀尚,畠山鎮次
    • Organizer
      日本生化学会
    • Place of Presentation
      東北大学川内北キャンパス(宮城県 仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Role of Human Mediator Subunit Med26 in Transcription Elongation2015

    • Author(s)
      Hidehisa Takahashi, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県、神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex2015

    • Author(s)
      Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, Delnur Anwar, Mio Shibata, Chieri Tomomori-Sato, Shigeo Sato, Amol Ranjan, Chris W. Seidel, Tadasuke Tsukiyama, Wataru Mizushima, Joan W. Conaway, Ronald C. Conaway, Shigetsugu Hatakeyama.
    • Organizer
      Mechanism of Eukaryotic Transcription
    • Place of Presentation
      Cold spring harbor laboratory(NY, USA)
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Med26はLittle elongation complexをリクルートすることでsmall nuclear RNA遺伝子の発現を制御する2015

    • Author(s)
      高橋秀尚, 畠山鎮次
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌(北海道札幌市中央区)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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