| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
|
|---|
| Outline of Final Research Achievements |
In response to proteotoxic stresses including heat shock, cells maintain protein homeostasis through an adaptive response called the heat shock response. This response is regulated at a level of transcription by heat shock transcription factor 1 (HSF1). We here show that HSF1 interacts with SSBP1, which is involved in replication and metabolism of mitochondrial DNA. Furthermore, HSF1-SSBP1 accumulates in the nucleus and maintains mitochondrial function during proteotoxic stress.
|
