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Regulation of the heat shock response by mitochondrial signals

Research Project

Project/Area Number 15H04706
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionYamaguchi University

Principal Investigator

NAKAI Akira  山口大学, 大学院医学系研究科, 教授 (60252516)

Co-Investigator(Kenkyū-buntansha) 藤本 充章  山口大学, 大学院医学系研究科, 准教授 (80359900)
瀧井 良祐  山口大学, 大学院医学系研究科, 助教 (00419558)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsprotein homeostasis / heat shock / chaperone / transcription / mitochondria / HSF1 / SSBP1 / シャペロン / 転写 / ストレス / ミトコンドリア / プロテオスタシス / 熱ストレス
Outline of Final Research Achievements

In response to proteotoxic stresses including heat shock, cells maintain protein homeostasis through an adaptive response called the heat shock response. This response is regulated at a level of transcription by heat shock transcription factor 1 (HSF1). We here show that HSF1 interacts with SSBP1, which is involved in replication and metabolism of mitochondrial DNA. Furthermore, HSF1-SSBP1 accumulates in the nucleus and maintains mitochondrial function during proteotoxic stress.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report

Research Products

(54 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation Book Remarks

  • [Int'l Joint Research] Children's National Medical Center/Yale University School of Medicine/George Washington University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.2018

    • Author(s)
      Takii R, Kadowaki T, Tsukuba T, Yamamoto K.
    • Journal Title

      European Journal of Pharmacology

      Volume: 824 Pages: 48-56

    • DOI
      10.1016/j.ejphar.2018.01.028
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.2017

    • Author(s)
      Ishii Seiji、Torii Masaaki、Son Alexander I.、Rajendraprasad Meenu、Morozov Yury M.、Kawasawa Yuka Imamura、Salzberg Anna C.、Fujimoto Mitsuaki、Brennand Kristen、Nakai Akira、Mezger Valerie、Gage Fred H.、Rakic Pasko、Hashimoto-Torii Kazue
    • Journal Title

      Nature Communications

      Volume: 8 Pages: 15157-15157

    • DOI
      10.1038/ncomms15157
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein2017

    • Author(s)
      Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, Matsuyama H.
    • Journal Title

      Endocrinology

      Volume: 158 Pages: 2648-2658

    • DOI
      10.1210/en.2017-00132
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HSF1 and HSF3 cooperatively regulate the heat shock response in lizards.2017

    • Author(s)
      Takii Ryosuke、Fujimoto Mitsuaki、Matsuura Yuki、Wu Fangxu、Oshibe Namiko、Takaki Eiichi、Katiyar Arpit、Akashi Hiroshi、Makino Takashi、Kawata Masakado、Nakai Akira
    • Journal Title

      PLoS One

      Volume: 12

    • DOI
      10.1371/journal.pone.0180776
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.2017

    • Author(s)
      Fujimoto Mitsuaki、Takii Ryosuke、Takaki Eiichi、Katiyar Arpit、Nakato Ryuichiro、Shirahige Katsuhiko、Nakai Akira
    • Journal Title

      Nat Commun.

      Volume: 8 Pages: 1-16

    • DOI
      10.1038/s41467-017-01807-7
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term melatonin treatment delays ovarian aging2017

    • Author(s)
      Tamura H, Kawamoto M, Sato S, Tamura I, Maekawa R, Taketani T, Aasada H, Takaki E, Nakai A, Reiter RJ, Sugino N.
    • Journal Title

      J Pineal Res

      Volume: 印刷中

    • DOI
      10.1111/jpi.12381
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-TNF-α Agent Infliximab and Splenectomy Are Protective Against Renal Ischemia-Reperfusion Injury.2016

    • Author(s)
      Y. Nagata, M. Fujimoto, K. Nakamura, N. Isoyama, M. Matsumura, K. Fujikawa, K. Uchiyama, E. Takaki, R. Takii, A. Nakai, and H. Matsuyama.
    • Journal Title

      Transplantation.

      Volume: 100 Pages: 1675-1682

    • DOI
      10.1097/tp.0000000000001222
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading.2016

    • Author(s)
      Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K
    • Journal Title

      Acta physiologica (Oxford, England)

      Volume: 217 Pages: 325-337

    • DOI
      10.1111/apha.12692
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1.2016

    • Author(s)
      Kondo T., Hisatome I., Yoshimura S., Mahati E., Notsu T., Li P., Iitsuka K., Kato M., Ogura K., Miake J., Aiba T., Shimizu W., Kurata Y., Sakata S., Nakasone N., Ninomiya H., Nakai A., Higaki K., Kawata Y., Shirayoshi Y., Yoshida A., Yamamoto K.
    • Journal Title

      J Arrhythm. 2016 Oct;32(5):433-440.

      Volume: 32 Pages: 433-440

    • DOI
      10.1016/j.joa.2015.10.005
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells2016

    • Author(s)
      Mahati E., Li P., Kurata Y., Maharani N., Nobuhito I., Sakata S., Ogura K., Miake J., Aiba T., Shimizu W., Nakasone N., Ninomiya H., Higaki K., Yamamoto K., Nakai A., Shirayoshi Y., Hisatome I.
    • Journal Title

      Circ J

      Volume: 80 Issue: 12 Pages: 2443-2452

    • DOI
      10.1253/circj.CJ-16-0712
    • NAID
      130005284978
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse2016

    • Author(s)
      Tsuda J, Sugahara K, Hori T, Kanagawa E, Takaki E, Fujimoto M, Nakai A, Yamashita H.
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 136 Pages: 1097-1106

    • DOI
      10.1080/00016489.2016.1195012
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Molecular basis of HSF regulation.2016

    • Author(s)
      A. Nakai
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 23 Pages: 93-95

    • DOI
      10.1038/nsmb.3165
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015

    • Author(s)
      Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
    • Journal Title

      GLIA

      Volume: 63 Pages: 780-79

    • DOI
      10.1002/glia.22784
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.2015

    • Author(s)
      Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y.
    • Journal Title

      Eur J Immunol

      Volume: 0 Pages: 0-0

    • DOI
      10.1002/eji.201445293
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Retinoic acid has the potential to suppress endometriosis development.2015

    • Author(s)
      Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T, Asada H, Tamura H, Nakai A, Sugino N.
    • Journal Title

      Journal of Ovarian Research

      Volume: 8 Pages: 49-49

    • DOI
      10.1186/s13048-015-0179-6
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice.2015

    • Author(s)
      Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Goto K
    • Journal Title

      Acta Physiologica

      Volume: 215 Pages: 191-203

    • DOI
      10.1111/apha.12600
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ミトコンドリアのプロテオスタシス制御2015

    • Author(s)
      譚克、中井彰
    • Journal Title

      生化学

      Volume: 87 Pages: 758-761

    • NAID
      40020687468
    • Related Report
      2015 Annual Research Report
  • [Presentation] HSF1転写複合体解析による熱ショック応答機構の解明2017

    • Author(s)
      瀧井良祐、藤本充章、Arpit Katiyar、松本雅記、中井 彰
    • Organizer
      冬の若手ワークショップ2017
    • Place of Presentation
      一宮シーサイドオーツカ(千葉県・長生郡)
    • Year and Date
      2017-01-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] HSF1 in Stress and Health2017

    • Author(s)
      Akira Nakai
    • Organizer
      TARA seminar, Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HSF1 mediates DNA damage response by assisting with the redistribution of PARP12017

    • Author(s)
      Akira Nakai
    • Organizer
      8th International Congress on Stress Responses in Biology & Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of heat shock response by HSF1-PARP complex in mammalian cells2017

    • Author(s)
      Mitsuaki Fujimoto, Ryosuke Takii, Arpit Katiyar, and Akira Nakai
    • Organizer
      8th International Congress on Stress Responses in Biology & Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] HSF1 and HSF3 cooperatively regulate the heat shock response in lizards2017

    • Author(s)
      Ryosuke Takii, Mitsuaki Fujimoto, Arpit Katiyar, Pratibha Srivastava, and Akira Nakai
    • Organizer
      8th International Congress on Stress Responses in Biology & Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] HSF1の新たな機能とがん2017

    • Author(s)
      藤本充章、中井 彰
    • Organizer
      第34回日本ハイパーサーミア学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HSF1の活性調節に働くリン酸化部位Ser326は進化的に保存されている2017

    • Author(s)
      瀧井良祐、藤本充章、Arpit Katiyar、Pratibha Srivastava、中井 彰
    • Organizer
      第12回臨床ストレス応答学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 染色体関連因子による熱ショック応答の制御2017

    • Author(s)
      瀧井良祐、中井 彰
    • Organizer
      2017年度 生命科学系学会合同年次大会 ワークショップ「プロテオスタシス制御の新展開と疾患」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HSF1-PARP複合体による熱ショック応答の調節2017

    • Author(s)
      藤本充章、瀧井良祐、Katiyar Arpit、Srivastava Pratibha, 中井 彰
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HSF1 in co-operation with SSBP1 regulates mitochondrial proteotoxic stress response in mammals2017

    • Author(s)
      Katiyar Arpit, Mitsuaki Fujimoto, Ryosuke Takii, Pratibha Srivastava, and Akira Nakai
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 熱ショック応答と神経疾患およびがん2017

    • Author(s)
      中井 彰
    • Organizer
      理研セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 熱ショック応答とDNA修復機構2017

    • Author(s)
      藤本充章
    • Organizer
      群馬大学生体調節研究所 内分泌・代謝学共同利用共同研究拠点セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HSF1転写複合体の同定と機能解析2016

    • Author(s)
      瀧井良祐、藤本充章、Arpit Katiyar、松本雅記、中井 彰
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] HSF1 is a common regulator of cytoplasmic and mitochondria-specific proteotoxic stress responses in mammals.2016

    • Author(s)
      Arpit Katiyar, Mitsuaki Fujimoto, Ryosuke Takii, and Akira Nakai.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Anti-TNFa agent Infliximab and splenectomy are protective against renal ischemia-reperfusion injury.2016

    • Author(s)
      永田雄大、磯山直仁、内山浩一、中井 彰、松山豪泰
    • Organizer
      第68回西日本泌尿器科学会総会
    • Place of Presentation
      海峡メッセ下関(山口県・下関市)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 熱ショック応答におけるポリADPリボシル化酵素の役割2016

    • Author(s)
      藤本 充章、瀧井良祐、Arpit Katiyar、中井 彰
    • Organizer
      第11回臨床ストレス応答学会大会
    • Place of Presentation
      山口大学(山口県・宇部市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HSF1 is a regulator of mitochondrial HSP genes in mammals.2016

    • Author(s)
      Arpit Katiyar, Mitsuaki Fujimoto, Ryosuke Takii, Ke Tan, and Akira Nakai.
    • Organizer
      第11回臨床ストレス応答学会大会
    • Place of Presentation
      山口大学(山口県・宇部市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] マウスLeydig細胞でのステロイド合成におけるHSF1の役割2016

    • Author(s)
      岡 真太郎、白石弘司、藤本充章、Arpit Katiyar、瀧井良祐、中井 彰、松山豪泰
    • Organizer
      第11回臨床ストレス応答学会大会
    • Place of Presentation
      山口大学(山口県・宇部市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] HSF1-SSBP1 complex maintains mitochondrial function via upregulation of NRF1 expression during heat shock.2016

    • Author(s)
      Ke Tan, Yumei Fan, Arpit Katiyar, Mitsuaki Fujimoto, Ryosuke Takii, Akira Nakai, and Xianglin Duan.
    • Organizer
      第11回臨床ストレス応答学会大会
    • Place of Presentation
      山口大学(山口県・宇部市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] HSF1転写複合体による細胞の恒常性維持機構2016

    • Author(s)
      中井 彰
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市))
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 進化的アプローチによる熱ショック因子HSF1転写複合体の同定2016

    • Author(s)
      瀧井良祐、藤本充章、高木栄一、Arpit Katiyar、松本雅記、中井 彰
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 熱ショック応答によるミトコンドリアのプロテオスタシス制御2016

    • Author(s)
      中井 彰
    • Organizer
      第12回レドックス・ライフイノベーションシンポジウム
    • Place of Presentation
      熊本大学(熊本県・熊本市)
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HSF1-PARP複合体はDNA損傷応答に関与する2016

    • Author(s)
      藤本充章、瀧井良祐、高木栄一、Arpit Katiyar、中井 彰
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation of proteostasis and the heat shock response.2016

    • Author(s)
      Akira Nakai
    • Organizer
      College of Life Science, Hebei Normal University
    • Place of Presentation
      Shijiazhuang, China
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] タンパク質毒性ストレス応答とDNA損傷ストレス応答の接点2015

    • Author(s)
      藤本充章、中井彰
    • Organizer
      第88回日本生化学会大会・第38回日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 進化的アプローチによる熱ショック因子HSF1の転写関連領域の解析2015

    • Author(s)
      瀧井良祐、藤本充章、高木栄一、譚克、中井 彰
    • Organizer
      第88回日本生化学会大会・第38回日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス視床下部における熱ショック因子HSF4の解析2015

    • Author(s)
      高木栄一、藤本充章、瀧井良祐、譚克、中井 彰
    • Organizer
      第88回日本生化学会大会・第38回日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pathological brain development elicited heterogenous activation of stress responsive signaling under exposure to environmental stress.2015

    • Author(s)
      Seiji Ishii, Alexander I. Son, Meenu Rajendraprasad, Yury Morozov, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred Gage, Masaaki Torii, Pasko Rakic, Kazue Hashimoto-Torii.
    • Organizer
      第88回日本生化学会大会・第38回日本分子生物学会大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎虚血再灌流障害における脾臓摘出および抗TNF-α製剤の効果2015

    • Author(s)
      永田雄大、中村公彦、磯山直仁、松村正文、藤川公樹、内山浩一、中井 彰、松山豪泰
    • Organizer
      臨床ストレス応答学会
    • Place of Presentation
      東京農工大学、東京
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Heat shock response is modulated by poly(ADP-ribose) polymerases in mammalian cells.2015

    • Author(s)
      A. Nakai
    • Organizer
      The 7th international congress on stress response in biology and medicine
    • Place of Presentation
      Huangshan, China
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.2015

    • Author(s)
      Ke Tan, Mitsuaki Fujimoto, Ryosuke Takii, Eiichi Takaki, Akira Nakai
    • Organizer
      The 7th international congress on stress response in biology and medicine
    • Place of Presentation
      Huangshan, China
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] Heat Shock Factor2016

    • Author(s)
      A. Nakai
    • Total Pages
      301
    • Publisher
      Springer, Japan
    • Related Report
      2015 Annual Research Report
  • [Book] 南山堂医学大事典2015

    • Author(s)
      中井 彰、他
    • Total Pages
      3101
    • Publisher
      南山堂
    • Related Report
      2015 Annual Research Report
  • [Remarks] 山口大学大学院医学系研究科医化学講座

    • URL
      http://ds22.cc.yamaguchi-u.ac.jp/~seika2/
    • Related Report
      2017 Annual Research Report
  • [Remarks] 山口大学大学院医学系研究科 医化学講座

    • URL
      http://ds22.cc.yamaguchi-u.ac.jp/~seika2/
    • Related Report
      2016 Annual Research Report
  • [Remarks] 医化学研究室ホームページ

    • URL
      http://ds22.cc.yamaguchi-u.ac.jp/~seika2/
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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