Regulation of the heat shock response by mitochondrial signals
| Project/Area Number |
15H04706
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NAKAI Akira 山口大学, 大学院医学系研究科, 教授 (60252516)
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| Co-Investigator(Kenkyū-buntansha) |
藤本 充章 山口大学, 大学院医学系研究科, 准教授 (80359900)
瀧井 良祐 山口大学, 大学院医学系研究科, 助教 (00419558)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | protein homeostasis / heat shock / chaperone / transcription / mitochondria / HSF1 / SSBP1 / シャペロン / 転写 / ストレス / ミトコンドリア / プロテオスタシス / 熱ストレス |
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| Outline of Final Research Achievements |
In response to proteotoxic stresses including heat shock, cells maintain protein homeostasis through an adaptive response called the heat shock response. This response is regulated at a level of transcription by heat shock transcription factor 1 (HSF1). We here show that HSF1 interacts with SSBP1, which is involved in replication and metabolism of mitochondrial DNA. Furthermore, HSF1-SSBP1 accumulates in the nucleus and maintains mitochondrial function during proteotoxic stress.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Long-term melatonin treatment delays ovarian aging2017
Author(s)
Tamura H, Kawamoto M, Sato S, Tamura I, Maekawa R, Taketani T, Aasada H, Takaki E, Nakai A, Reiter RJ, Sugino N.
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DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anti-TNF-α Agent Infliximab and Splenectomy Are Protective Against Renal Ischemia-Reperfusion Injury.2016
Author(s)
Y. Nagata, M. Fujimoto, K. Nakamura, N. Isoyama, M. Matsumura, K. Fujikawa, K. Uchiyama, E. Takaki, R. Takii, A. Nakai, and H. Matsuyama.
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Journal Title
Transplantation.
Volume: 100
Pages: 1675-1682
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading.2016
Author(s)
Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K
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Journal Title
Acta physiologica (Oxford, England)
Volume: 217
Pages: 325-337
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1.2016
Author(s)
Kondo T., Hisatome I., Yoshimura S., Mahati E., Notsu T., Li P., Iitsuka K., Kato M., Ogura K., Miake J., Aiba T., Shimizu W., Kurata Y., Sakata S., Nakasone N., Ninomiya H., Nakai A., Higaki K., Kawata Y., Shirayoshi Y., Yoshida A., Yamamoto K.
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Journal Title
J Arrhythm. 2016 Oct;32(5):433-440.
Volume: 32
Pages: 433-440
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells2016
Author(s)
Mahati E., Li P., Kurata Y., Maharani N., Nobuhito I., Sakata S., Ogura K., Miake J., Aiba T., Shimizu W., Nakasone N., Ninomiya H., Higaki K., Yamamoto K., Nakai A., Shirayoshi Y., Hisatome I.
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Journal Title
Circ J
Volume: 80
Issue: 12
Pages: 2443-2452
DOI
NAID
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[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki, Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto and Yuji Owada
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Journal Title
GLIA
Volume: 63
Pages: 780-79
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[Journal Article] Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.2015
Author(s)
Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y.
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Journal Title
Eur J Immunol
Volume: 0
Pages: 0-0
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Retinoic acid has the potential to suppress endometriosis development.2015
Author(s)
Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, Sato S, Maekawa R, Taketani T, Asada H, Tamura H, Nakai A, Sugino N.
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Journal Title
Journal of Ovarian Research
Volume: 8
Pages: 49-49
DOI
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Pathological brain development elicited heterogenous activation of stress responsive signaling under exposure to environmental stress.2015
Author(s)
Seiji Ishii, Alexander I. Son, Meenu Rajendraprasad, Yury Morozov, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred Gage, Masaaki Torii, Pasko Rakic, Kazue Hashimoto-Torii.
Organizer
第88回日本生化学会大会・第38回日本分子生物学会大会
Place of Presentation
神戸国際会議場、神戸
Year and Date
2015-12-01
Related Report
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