| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Sulfomucin (SuM) is sulfated O-glycan attached to specific scaffold proteins. In order to elucidate the role of SuM in gastric cancer development, we generated A4gnt/Chst4 double-knockout (DKO) mice by crossing A4gnt knockout mice that spontaneously develop differentiated-type gastric adenocarcinoma and Chst4 knockout mice that are defective in the sulfotransferase, GlcNAc6ST-2. A4gnt/Chst4 DKO mice developed differentiated-type gastric adenocarcinoma as they aged alike A4gnt KO mice. However, gastric erosion took place in A4gnt/Chst4 DKO mice as early as 3-weeks of age, and these lesions were eventually taken over by gastritis cystica profunca (GCP). In human early differentiated-type gastric adenocarcinoma, GCP was significantly associated with adenocarcinoma without SuM production than adenocarcinoma with SuM production. These results combined together indicate that SuM played essential role in preventing GCP in adenocarcioma but a minor role in gastric cancer progression.
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