Elucidation of sulfomucin-mediated gastric carcinogenesis
| Project/Area Number |
15H04712
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
Nakayama Jun 信州大学, 学術研究院医学系, 教授 (10221459)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 胃粘液 / 硫酸化糖鎖 / 糖転移酵素 / 硫酸転移酵素 / ダブルノックアウトマウス / 粘膜下異所性腺 / 胃癌 / ムチン / 糖鎖遺伝子 / ノックアウトマウス |
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| Outline of Final Research Achievements |
Sulfomucin (SuM) is sulfated O-glycan attached to specific scaffold proteins. In order to elucidate the role of SuM in gastric cancer development, we generated A4gnt/Chst4 double-knockout (DKO) mice by crossing A4gnt knockout mice that spontaneously develop differentiated-type gastric adenocarcinoma and Chst4 knockout mice that are defective in the sulfotransferase, GlcNAc6ST-2. A4gnt/Chst4 DKO mice developed differentiated-type gastric adenocarcinoma as they aged alike A4gnt KO mice. However, gastric erosion took place in A4gnt/Chst4 DKO mice as early as 3-weeks of age, and these lesions were eventually taken over by gastritis cystica profunca (GCP). In human early differentiated-type gastric adenocarcinoma, GCP was significantly associated with adenocarcinoma without SuM production than adenocarcinoma with SuM production. These results combined together indicate that SuM played essential role in preventing GCP in adenocarcioma but a minor role in gastric cancer progression.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Cloning of Helicobacter suis cholesterol α-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections,2017
Author(s)
Masatomo Kawakubo, Kazuki Horiuchi, Hitomi Komura, Yoshiko Sato, Masayoshi Kato, Meguru Ikeyama, Mana Fukushima, Shigenori Yamada, Satoshi Ishizone, Takehisa Matsumoto, Hiroyoshi Ota, Junji Sagara, Jun Nakayama
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Journal Title
Histochemistry and Cell Biology
Volume: 印刷中
Issue: 4
Pages: 463-471
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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