Identification and clinical application of diagnostic and therapeutic marker of esophageal and gastric cancer targeting cancer stem cell
| Project/Area Number | 15H04713 |
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YASUI WATARU 広島大学, 医歯薬保健学研究科(医), 教授 (40191118)
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| Co-Investigator(Renkei-kenkyūsha) |
OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究科, 准教授 (60346484)
KUNIYASU HIROKI 奈良県立医科大学, 医学部, 教授 (00253055)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed(Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost : ¥13,300,000、Indirect Cost : ¥3,990,000)
Fiscal Year 2017 : ¥4,940,000 (Direct Cost : ¥3,800,000、Indirect Cost : ¥1,140,000)
Fiscal Year 2016 : ¥5,850,000 (Direct Cost : ¥4,500,000、Indirect Cost : ¥1,350,000)
Fiscal Year 2015 : ¥6,500,000 (Direct Cost : ¥5,000,000、Indirect Cost : ¥1,500,000)
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| Keywords | 食道癌 / 胃癌 / 癌幹細胞 / CAST法 / 新規診断・治療標的 / Spheroid / KIFC1 / KIF23 / DSG1 / IQGAP3 / MCOLN3 / BST2 |
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| Outline of Final Research Achievements |
As candidate diagnostic and therapeutic targets of esophageal and gastric cancers associated with spheroid-forming cancer stem cells, kinesin family (KIFC1, KIF11, KIF23), IQGAP3, DSG1 were identified. BST2 and MCOLN3, identified from 5-FU-resistant gastric cancer cells, were found to regulate chemosensitivity. These findings will contribute to the application to the diagnosis and treatment for therapy-resistant cancer stem cells.
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Report
(4results)
Research Products
(63results)
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[Journal Article] Overexpression of PCDHB9 promotes peritoneal metastasis and correlates with poor prognosis in patients with gastric cancer.2017
Author(s)
Mukai S, Oue N, Oshima T, Imai T, Sekino Y, Honma R, Sakamoto N, Sentani K, Kuniyasu H, Egi H, Tanabe K, Yoshida K, Ohdan H, Yasui W.
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Journal Title
J Pathol
Volume : 243
Pages : 100-110
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer.2017
Author(s)
Mukai S, Oue N, Oshima T, Mukai R, Tatsumoto Y, Sakamoto N, Sentani K, Tanabe K, Egi H, Hinoi T, Ohdan H, Yasui W.
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Journal Title
Ann Surg Oncol
Volume : 24
Pages : 594-602
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Overexpression of transmembrane protein BST2, participating in cell growth, is associated with poor survival in patients with esophageal, gastric and colorectal cancer2016
Author(s)
Mukai S, Oue N, Oshima T, Tatsumoto Y, Sakamoto N, Sentani N, Hinoi T, Ohdan H, Yasui W
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Journal Title
Ann Surg Oncol
Volume : 印刷中
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer.2016
Author(s)
Oo HZ, Sentani K, Mukai S, Hattori T, Shinmei S, Goto K, Sakamoto N, Naito Y, Anami K, Trang PT, Yanagihara K, Oue N, Yasui W.
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Journal Title
Gastric Cancer
Volume : 19
Pages : 443-452
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Tetraspanin 8, identified by the Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer2016
Author(s)
Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Naito Y, Oo HZ, Yasui W
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Journal Title
Gastric Cancer
Volume : 19
Pages : 370-380
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] New molecular staging with G-factor supplements TNM classification in gastric cancer: A multicenter collaborative research by the Japanese Society for Gastroenterological Carcinogenesis G-Project committee2015
Author(s)
Sawada T, Yashiro M, Sentani K, Oue N, Yasui W, Miyazaki K, Kai K, Fushida S, Fujimura T, Ohira M, Kakeji Y, Natsugoe S, Shirabe K, Nomura S, Shimada Y, Tomita N, Hirakawa K, Maehara Y
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Journal Title
Gastric Cancer
Volume : 18
Pages : 119-128
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer.2015
Author(s)
Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W, Ochiai A.
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Journal Title
Cancer Med.
Volume : 4
Pages : 1667-1678
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Assessment and clinical application of markers for stratification of recurrence risk after curative resection of stage II/III gastric cancer2016
Author(s)
Oshima T, Kimura Y, Sakamaki K, Miyagi Y, Yamanaka S, Oue N, Cho H, Yoshikawa T, Rino Y, Yasui W, Imada T, Masuda M
Organizer
The 2016 ASCO Annual Meeting
Place of Presentation
Illinois, Chicago (USA)
Year and Date
2016-06-03
Related Report
Int'l Joint Research
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