| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Outline of Final Research Achievements |
Lung cancers without driver mutations (EGFR, KRAS, ALK etc.) are thought to relate with exogenous carcinogens such as smoking. In this study, we focused on exposure to cigarette smoke and asbestos and comprehensively investigated mRNA and miRNA expression. By comparing cumulative smoking, asbestos burden with miRNA expression, we successfully identified specific miRNA to asbestos exposure. Although we attempted to perform integrated analysis using mRNA and miRNA expression, clusters drawn from mRNA and miRNA were not identical. Also, we examined PD-L1 expression in adenocarcinoma and small cell carcinoma and found that PD-L1 expression in small cell carcinoma was unexpectedly a marker for good prognosis.
|
