| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|
|---|
| Outline of Final Research Achievements |
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis. Immunity to Leishmania infection has been shown to depend on the development of Th1 cells; however, the roles of B cells and antibodies during infection remain unclear. In this study, we found that the mice lacking circulating immunoglobulins (cIgs-deficient mice) became resistant to VL. IFN-γ depletion did not affect the rapid reduction of parasite burden, whereas NADPH oxidases was up-regulated in the livers of infected cIgs-deficient mice. The inhibition of the reactive oxygen species pathway in vivo by a NADPH oxidase inhibitor resulted in a significant increase in the parasite burden in cIgs-deficient mice. These results indicate that a circulating Ig deficiency induces a protective response against VL by elevating IFN-γ-independent NADPH oxidase activity, and also that cIgs play a regulatory role in controlling murine VL.
|
