High-throughput screening for chemical compounds which restict intracellular bacteria
| Project/Area Number |
15H04728
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Gifu University (2016-2017)
Osaka University (2015) |
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Principal Investigator |
Nagai Hiroki 岐阜大学, 大学院医学系研究科, 教授 (80222173)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | 細菌 / 化合物ライブラリ / 細胞内寄生 / 化合物ライブラリー |
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| Outline of Final Research Achievements |
Legionella pneumophila is a causative bacterium of a severe form of pneumonia known as legionellosis. We conducted high-throughput screening for chemical compounds which specifically impair Legionella growth within host cells. Some of the compounds we have identified appear to target host cellular pathways which have never been implicated in intracellular survival and replication of microorganisms.
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Report
(4 results)
Research Products
(11 results)
