| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Inflammasome is macromolecule complexes in the host cells upon being activated by pathogen infection or metabolites in the body. Caspase-1 activation is finely regulated by inflammasome that forms with Nod-like receptors (NLRs), and then activated caspase-1 can cleave pro-IL-1 or IL-18, and convert their bioactive cytokines. Among NLRs, NLRP3 is involved in chronic inflammatory diseases such as type II Diabetes or gout, because NLRP3 inflammasome can be activated by several metabolites including saturated fatty acids, cholesterol or uric acids crystals. In this work, we found new signaling pathway for activating NLRP3 inflammasome. The lysosome integrity-galectin-3 accumulation-NLRP3 activation axis may provide important insights into NLRP3 inflammasome activation in host cells.
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